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How do lncRNAs regulate transcription?

Long Y, Wang X, Youmans DT, Cech TR.

Sci Adv. 2017 Sep 27;3(9):eaao2110. doi: 10.1126/sciadv.aao2110. eCollection 2017 Sep. Review.


Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines.

Wang X, Goodrich KJ, Gooding AR, Naeem H, Archer S, Paucek RD, Youmans DT, Cech TR, Davidovich C.

Mol Cell. 2017 Mar 16;65(6):1056-1067.e5. doi: 10.1016/j.molcel.2017.02.003.


Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing.

Goldfarb KC, Cech TR.

Genes Dev. 2017 Jan 1;31(1):59-71. doi: 10.1101/gad.286963.116. Epub 2017 Jan 23.


Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres.

Schmidt JC, Zaug AJ, Cech TR.

Cell. 2016 Aug 25;166(5):1188-1197.e9. doi: 10.1016/j.cell.2016.07.033. Epub 2016 Aug 11.


RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure.

Lu Z, Zhang QC, Lee B, Flynn RA, Smith MA, Robinson JT, Davidovich C, Gooding AR, Goodrich KJ, Mattick JS, Mesirov JP, Cech TR, Chang HY.

Cell. 2016 May 19;165(5):1267-1279. doi: 10.1016/j.cell.2016.04.028. Epub 2016 May 12.


Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.

Shukla S, Schmidt JC, Goldfarb KC, Cech TR, Parker R.

Nat Struct Mol Biol. 2016 Apr;23(4):286-92. doi: 10.1038/nsmb.3184. Epub 2016 Mar 7.


Protein-RNA interaction restricts telomerase from running through the stop sign.

Xi L, Cech TR.

Nat Struct Mol Biol. 2015 Nov;22(11):835-6. doi: 10.1038/nsmb.3118. No abstract available.


The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2.

Davidovich C, Cech TR.

RNA. 2015 Dec;21(12):2007-22. doi: 10.1261/rna.053918.115. Review.


A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.

Xi L, Schmidt JC, Zaug AJ, Ascarrunz DR, Cech TR.

Genome Biol. 2015 Nov 10;16:231. doi: 10.1186/s13059-015-0791-1.


Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers.

Stern JL, Theodorescu D, Vogelstein B, Papadopoulos N, Cech TR.

Genes Dev. 2015 Nov 1;29(21):2219-24. doi: 10.1101/gad.269498.115. Epub 2015 Oct 29.


Nucleic acid-binding specificity of human FUS protein.

Wang X, Schwartz JC, Cech TR.

Nucleic Acids Res. 2015 Sep 3;43(15):7535-43. doi: 10.1093/nar/gkv679. Epub 2015 Jul 6.


Human telomerase: biogenesis, trafficking, recruitment, and activation.

Schmidt JC, Cech TR.

Genes Dev. 2015 Jun 1;29(11):1095-105. doi: 10.1101/gad.263863.115. Review.


RNA World research-still evolving.

Cech TR.

RNA. 2015 Apr;21(4):474-5. doi: 10.1261/rna.049965.115. No abstract available.


Cancer. TERT promoter mutations and telomerase reactivation in urothelial cancer.

Borah S, Xi L, Zaug AJ, Powell NM, Dancik GM, Cohen SB, Costello JC, Theodorescu D, Cech TR.

Science. 2015 Feb 27;347(6225):1006-10. doi: 10.1126/science.1260200. Epub 2015 Feb 5.


Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase.

Dalby AB, Hofr C, Cech TR.

J Mol Biol. 2015 Mar 27;427(6 Pt B):1291-303. doi: 10.1016/j.jmb.2015.01.008. Epub 2015 Jan 23.


Toward a consensus on the binding specificity and promiscuity of PRC2 for RNA.

Davidovich C, Wang X, Cifuentes-Rojas C, Goodrich KJ, Gooding AR, Lee JT, Cech TR.

Mol Cell. 2015 Feb 5;57(3):552-8. doi: 10.1016/j.molcel.2014.12.017. Epub 2015 Jan 15.


Biochemical Properties and Biological Functions of FET Proteins.

Schwartz JC, Cech TR, Parker RR.

Annu Rev Biochem. 2015;84:355-79. doi: 10.1146/annurev-biochem-060614-034325. Epub 2014 Dec 8. Review.


Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance.

Tang M, Li Y, Zhang Y, Chen Y, Huang W, Wang D, Zaug AJ, Liu D, Zhao Y, Cech TR, Ma W, Songyang Z.

J Cell Sci. 2015 Jan 15;128(2):331-41. doi: 10.1242/jcs.159467. Epub 2014 Nov 21.


Academia and industry: Companies on campus.

Watson-Capps JJ, Cech TR.

Nature. 2014 Oct 16;514(7522):297-8. doi: 10.1038/514297a. No abstract available.


Identification of human TERT elements necessary for telomerase recruitment to telomeres.

Schmidt JC, Dalby AB, Cech TR.

Elife. 2014 Oct 1;3. doi: 10.7554/eLife.03563.

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