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A Lifelong Passion for All Things Ribonucleic.

Cech TR.

Cell. 2018 Sep 20;175(1):14-17. doi: 10.1016/j.cell.2018.08.037. Epub 2018 Sep 11.


Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA.

Greenwood J, Patel H, Cech TR, Cooper JP.

Nucleic Acids Res. 2018 Sep 28;46(17):8865-8875. doi: 10.1093/nar/gky605.


In Crystallo Selection to Establish New RNA Crystal Contacts.

Shoffner GM, Wang R, Podell E, Cech TR, Guo F.

Structure. 2018 Sep 4;26(9):1275-1283.e3. doi: 10.1016/j.str.2018.05.005. Epub 2018 Jun 14.


Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits.

Youmans DT, Schmidt JC, Cech TR.

Genes Dev. 2018 Jun 1;32(11-12):794-805. doi: 10.1101/gad.311936.118. Epub 2018 Jun 11.


Dynamics of human telomerase recruitment depend on template- telomere base pairing.

Schmidt JC, Zaug AJ, Kufer R, Cech TR.

Mol Biol Cell. 2018 Jan 31. pii: mbc.E17-11-0637. doi: 10.1091/mbc.E17-11-0637. [Epub ahead of print]


Allele-Specific DNA Methylation and Its Interplay with Repressive Histone Marks at Promoter-Mutant TERT Genes.

Stern JL, Paucek RD, Huang FW, Ghandi M, Nwumeh R, Costello JC, Cech TR.

Cell Rep. 2017 Dec 26;21(13):3700-3707. doi: 10.1016/j.celrep.2017.12.001.


Conserved RNA-binding specificity of polycomb repressive complex 2 is achieved by dispersed amino acid patches in EZH2.

Long Y, Bolanos B, Gong L, Liu W, Goodrich KJ, Yang X, Chen S, Gooding AR, Maegley KA, Gajiwala KS, Brooun A, Cech TR, Liu X.

Elife. 2017 Nov 29;6. pii: e31558. doi: 10.7554/eLife.31558.


Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA.

Wang X, Paucek RD, Gooding AR, Brown ZZ, Ge EJ, Muir TW, Cech TR.

Nat Struct Mol Biol. 2017 Dec;24(12):1028-1038. doi: 10.1038/nsmb.3487. Epub 2017 Oct 23.


Reconstitution of human shelterin complexes reveals unexpected stoichiometry and dual pathways to enhance telomerase processivity.

Lim CJ, Zaug AJ, Kim HJ, Cech TR.

Nat Commun. 2017 Oct 20;8(1):1075. doi: 10.1038/s41467-017-01313-w.


How do lncRNAs regulate transcription?

Long Y, Wang X, Youmans DT, Cech TR.

Sci Adv. 2017 Sep 27;3(9):eaao2110. doi: 10.1126/sciadv.aao2110. eCollection 2017 Sep. Review.


Targeting of Polycomb Repressive Complex 2 to RNA by Short Repeats of Consecutive Guanines.

Wang X, Goodrich KJ, Gooding AR, Naeem H, Archer S, Paucek RD, Youmans DT, Cech TR, Davidovich C.

Mol Cell. 2017 Mar 16;65(6):1056-1067.e5. doi: 10.1016/j.molcel.2017.02.003.


Targeted CRISPR disruption reveals a role for RNase MRP RNA in human preribosomal RNA processing.

Goldfarb KC, Cech TR.

Genes Dev. 2017 Jan 1;31(1):59-71. doi: 10.1101/gad.286963.116. Epub 2017 Jan 23.


Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres.

Schmidt JC, Zaug AJ, Cech TR.

Cell. 2016 Aug 25;166(5):1188-1197.e9. doi: 10.1016/j.cell.2016.07.033. Epub 2016 Aug 11.


RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure.

Lu Z, Zhang QC, Lee B, Flynn RA, Smith MA, Robinson JT, Davidovich C, Gooding AR, Goodrich KJ, Mattick JS, Mesirov JP, Cech TR, Chang HY.

Cell. 2016 May 19;165(5):1267-1279. doi: 10.1016/j.cell.2016.04.028. Epub 2016 May 12.


Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects.

Shukla S, Schmidt JC, Goldfarb KC, Cech TR, Parker R.

Nat Struct Mol Biol. 2016 Apr;23(4):286-92. doi: 10.1038/nsmb.3184. Epub 2016 Mar 7.


Protein-RNA interaction restricts telomerase from running through the stop sign.

Xi L, Cech TR.

Nat Struct Mol Biol. 2015 Nov;22(11):835-6. doi: 10.1038/nsmb.3118. No abstract available.


The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2.

Davidovich C, Cech TR.

RNA. 2015 Dec;21(12):2007-22. doi: 10.1261/rna.053918.115. Review.


A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression.

Xi L, Schmidt JC, Zaug AJ, Ascarrunz DR, Cech TR.

Genome Biol. 2015 Nov 10;16:231. doi: 10.1186/s13059-015-0791-1.


Mutation of the TERT promoter, switch to active chromatin, and monoallelic TERT expression in multiple cancers.

Stern JL, Theodorescu D, Vogelstein B, Papadopoulos N, Cech TR.

Genes Dev. 2015 Nov 1;29(21):2219-24. doi: 10.1101/gad.269498.115. Epub 2015 Oct 29.


Nucleic acid-binding specificity of human FUS protein.

Wang X, Schwartz JC, Cech TR.

Nucleic Acids Res. 2015 Sep 3;43(15):7535-43. doi: 10.1093/nar/gkv679. Epub 2015 Jul 6.

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