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Toxoplasma Cathepsin Protease B and Aspartyl Protease 1 Are Dispensable for Endolysosomal Protein Digestion.

McDonald C, Smith D, Di Cristina M, Kannan G, Dou Z, Carruthers VB.

mSphere. 2020 Feb 12;5(1). pii: e00869-19. doi: 10.1128/mSphere.00869-19.


Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS.

Zwicker JD, Smith D, Guerra AJ, Hitchens JR, Haug N, Vander Roest S, Lee P, Wen B, Sun D, Wang L, Keep RF, Xiang J, Carruthers VB, Larsen SD.

ACS Chem Neurosci. 2020 Feb 18. doi: 10.1021/acschemneuro.9b00674. [Epub ahead of print]


Toxoplasma gondii: Bradyzoite Differentiation In Vitro and In Vivo.

Mayoral J, Di Cristina M, Carruthers VB, Weiss LM.

Methods Mol Biol. 2020;2071:269-282. doi: 10.1007/978-1-4939-9857-9_15.


PCR Screening of Toxoplasma gondii Single Clones Directly from 96-Well Plates Without DNA Purification.

Piro F, Carruthers VB, Di Cristina M.

Methods Mol Biol. 2020;2071:117-123. doi: 10.1007/978-1-4939-9857-9_6.


Role of Toxoplasma gondii Chloroquine Resistance Transporter in Bradyzoite Viability and Digestive Vacuole Maintenance.

Kannan G, Di Cristina M, Schultz AJ, Huynh MH, Wang F, Schultz TL, Lunghi M, Coppens I, Carruthers VB.

mBio. 2019 Aug 6;10(4). pii: e01324-19. doi: 10.1128/mBio.01324-19.


Interrupting Toxoplasma's Regularly Scheduled Program of Egress.

Carruthers VB.

Trends Parasitol. 2019 May;35(5):338-340. doi: 10.1016/ Epub 2019 Apr 1.


Protein O-fucosyltransferase 2-mediated O-glycosylation of the adhesin MIC2 is dispensable for Toxoplasma gondii tachyzoite infection.

Khurana S, Coffey MJ, John A, Uboldi AD, Huynh MH, Stewart RJ, Carruthers VB, Tonkin CJ, Goddard-Borger ED, Scott NE.

J Biol Chem. 2019 Feb 1;294(5):1541-1553. doi: 10.1074/jbc.RA118.005357. Epub 2018 Dec 4.


Structural basis of Toxoplasma gondii perforin-like protein 1 membrane interaction and activity during egress.

Guerra AJ, Zhang O, Bahr CME, Huynh MH, DelProposto J, Brown WC, Wawrzak Z, Koropatkin NM, Carruthers VB.

PLoS Pathog. 2018 Dec 4;14(12):e1007476. doi: 10.1371/journal.ppat.1007476. eCollection 2018 Dec.


Optimization of dipeptidic inhibitors of cathepsin L for improved Toxoplasma gondii selectivity and CNS permeability.

Zwicker JD, Diaz NA, Guerra AJ, Kirchhoff PD, Wen B, Sun D, Carruthers VB, Larsen SD.

Bioorg Med Chem Lett. 2018 Jun 1;28(10):1972-1980. doi: 10.1016/j.bmcl.2018.03.020. Epub 2018 Mar 9.


Toxoplasma gondii LCAT Primarily Contributes to Tachyzoite Egress.

Schultz AJ, Carruthers VB.

mSphere. 2018 Feb 28;3(1). pii: e00073-18. doi: 10.1128/mSphereDirect.00073-18. eCollection 2018 Jan-Feb.


New and emerging uses of CRISPR/Cas9 to genetically manipulate apicomplexan parasites.

Di Cristina M, Carruthers VB.

Parasitology. 2018 Aug;145(9):1119-1126. doi: 10.1017/S003118201800001X. Epub 2018 Feb 21. Review.


Intersection of endocytic and exocytic systems in Toxoplasma gondii.

McGovern OL, Rivera-Cuevas Y, Kannan G, Narwold AJ Jr, Carruthers VB.

Traffic. 2018 May;19(5):336-353. doi: 10.1111/tra.12556. Epub 2018 Mar 25.


Toward detection of toxoplasmosis from urine in mice using hydro-gel nanoparticles concentration and parallel reaction monitoring mass spectrometry.

Steinberg HE, Russo P, Angulo N, Ynocente R, Montoya C, Diestra A, Ferradas C, Schiaffino F, Florentini E, Jimenez J, Calderón M, Carruthers VB, Gilman RH, Liotta L, Luchini A.

Nanomedicine. 2018 Feb;14(2):461-469. doi: 10.1016/j.nano.2017.11.020. Epub 2017 Dec 1.


Structural Features of Apicomplexan Pore-Forming Proteins and Their Roles in Parasite Cell Traversal and Egress.

Guerra AJ, Carruthers VB.

Toxins (Basel). 2017 Aug 29;9(9). pii: E265. doi: 10.3390/toxins9090265. Review.


Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection.

Di Cristina M, Dou Z, Lunghi M, Kannan G, Huynh MH, McGovern OL, Schultz TL, Schultz AJ, Miller AJ, Hayes BM, van der Linden W, Emiliani C, Bogyo M, Besteiro S, Coppens I, Carruthers VB.

Nat Microbiol. 2017 Jun 19;2:17096. doi: 10.1038/nmicrobiol.2017.96.


A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes.

Sidik SM, Huet D, Ganesan SM, Huynh MH, Wang T, Nasamu AS, Thiru P, Saeij JPJ, Carruthers VB, Niles JC, Lourido S.

Cell. 2016 Sep 8;166(6):1423-1435.e12. doi: 10.1016/j.cell.2016.08.019. Epub 2016 Sep 2.


Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.

Vidadala RS, Rivas KL, Ojo KK, Hulverson MA, Zambriski JA, Bruzual I, Schultz TL, Huang W, Zhang Z, Scheele S, DeRocher AE, Choi R, Barrett LK, Siddaramaiah LK, Hol WG, Fan E, Merritt EA, Parsons M, Freiberg G, Marsh K, Kempf DJ, Carruthers VB, Isoherranen N, Doggett JS, Van Voorhis WC, Maly DJ.

J Med Chem. 2016 Jul 14;59(13):6531-46. doi: 10.1021/acs.jmedchem.6b00760. Epub 2016 Jul 1.


A Toxoplasma gondii Ortholog of Plasmodium GAMA Contributes to Parasite Attachment and Cell Invasion.

Huynh MH, Carruthers VB.

mSphere. 2016 Feb 10;1(1). pii: e00012-16. doi: 10.1128/mSphere.00012-16. eCollection 2016 Jan-Feb.


Toxoplasma Retromer Is Here to Stay.

McGovern OL, Carruthers VB.

Trends Parasitol. 2016 Oct;32(10):758-760. doi: 10.1016/ Epub 2016 May 27.


Cerebral complement C1q activation in chronic Toxoplasma infection.

Xiao J, Li Y, Gressitt KL, He H, Kannan G, Schultz TL, Svezhova N, Carruthers VB, Pletnikov MV, Yolken RH, Severance EG.

Brain Behav Immun. 2016 Nov;58:52-56. doi: 10.1016/j.bbi.2016.04.009. Epub 2016 Apr 22.

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