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Hum Pathol. 2010 Feb;41(2):271-80. doi: 10.1016/j.humpath.2009.07.022. Epub 2009 Dec 8.

CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas.

Author information

1
Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Abstract

CD81 is a tetraspanin cell surface protein that regulates CD19 expression in B lymphocytes and enables hepatitis C virus infection of human cells. Immunohistologic analysis in normal hematopoietic tissue showed strong staining for CD81 in normal germinal center B cells, a cell type in which its increased expression has not been previously recognized. High-dimensional flow cytometry analysis of normal hematopoietic tissue confirmed that among B- and T-cell subsets, germinal center B cells showed the highest level of CD81 expression. In more than 800 neoplastic tissue samples, its expression was also found in most non-Hodgkin lymphomas. Staining for CD81 was rarely seen in multiple myeloma, Hodgkin lymphoma, or myeloid leukemia. In hierarchical cluster analysis of diffuse large B-cell lymphoma, staining for CD81 was most similar to other germinal center B cell-associated markers, particularly LMO2. By flow cytometry, CD81 was expressed in diffuse large B-cell lymphoma cells independent of the presence or absence of CD10, another germinal center B-cell marker. The detection of CD81 in routine biopsy samples and its differential expression in lymphoma subtypes, particularly diffuse large B-cell lymphoma, warrant further study to assess CD81 expression and its role in the risk stratification of patients with diffuse large B-cell lymphoma.

PMID:
20004001
PMCID:
PMC2813949
DOI:
10.1016/j.humpath.2009.07.022
[Indexed for MEDLINE]
Free PMC Article

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