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2,305 results

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Page 1
CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling.
Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S. Oguri Y, et al. Cell. 2020 Aug 6;182(3):563-577.e20. doi: 10.1016/j.cell.2020.06.021. Epub 2020 Jul 1. Cell. 2020. PMID: 32615086 Free PMC article.
This beige APC population is proliferative and marked by cell-surface proteins, including PDGFRalpha, Sca1, and CD81. Notably, CD81 is not only a beige APC marker but also required for de novo beige fat biogenesis following cold exposure. ...Importantly, CD81
This beige APC population is proliferative and marked by cell-surface proteins, including PDGFRalpha, Sca1, and CD81. Notably, CD8
CD81 as a tumor target.
Vences-Catalán F, Duault C, Kuo CC, Rajapaksa R, Levy R, Levy S. Vences-Catalán F, et al. Biochem Soc Trans. 2017 Apr 15;45(2):531-535. doi: 10.1042/BST20160478. Biochem Soc Trans. 2017. PMID: 28408492 Review.
CD81 has also been shown to regulate cell migration and invasion, and has therefore been implicated in cancer progression. ...Here, we discuss the role of CD81 in cancer and its potential therapeutic use as a tumor target....
CD81 has also been shown to regulate cell migration and invasion, and has therefore been implicated in cancer progression. ...Here, w
The molecular mechanism of CD81 antibody inhibition of metastasis.
Abu-Saleh N, Kuo CC, Jiang W, Levy R, Levy S. Abu-Saleh N, et al. Proc Natl Acad Sci U S A. 2023 Jun 27;120(26):e2305042120. doi: 10.1073/pnas.2305042120. Epub 2023 Jun 20. Proc Natl Acad Sci U S A. 2023. PMID: 37339209 Free PMC article.
Metastases are reduced in CD81KO mice. In addition, a unique anti-CD81 antibody, 5A6, inhibits metastasis in vivo and invasion and migration in vitro. Here, we probed the structural components of CD81 required for the antimetastatic activity induced by 5A6. We found …
Metastases are reduced in CD81KO mice. In addition, a unique anti-CD81 antibody, 5A6, inhibits metastasis in vivo and invasion and mi …
CD81 and hepatitis C virus (HCV) infection.
Fénéant L, Levy S, Cocquerel L. Fénéant L, et al. Viruses. 2014 Feb 6;6(2):535-72. doi: 10.3390/v6020535. Viruses. 2014. PMID: 24509809 Free PMC article. Review.
This process is likely mediated through the formation of a tightly orchestrated complex of HCV entry factors at the plasma membrane. Among HCV entry factors, the tetraspanin CD81 is one of the best characterized and it is undoubtedly a key player in the HCV lifecycle. In t …
This process is likely mediated through the formation of a tightly orchestrated complex of HCV entry factors at the plasma membrane. Among H …
CD81 marks immature and dedifferentiated pancreatic beta-cells.
Salinno C, Büttner M, Cota P, Tritschler S, Tarquis-Medina M, Bastidas-Ponce A, Scheibner K, Burtscher I, Böttcher A, Theis FJ, Bakhti M, Lickert H. Salinno C, et al. Mol Metab. 2021 Jul;49:101188. doi: 10.1016/j.molmet.2021.101188. Epub 2021 Feb 11. Mol Metab. 2021. PMID: 33582383 Free PMC article.
Single-cell gene expression profiling and high-resolution imaging revealed an immature signature of beta-cells expressing high levels of CD81 (CD81(high)) compared to a more mature population expressing no or low levels of this protein (CD81(low/-)). ...Simil …
Single-cell gene expression profiling and high-resolution imaging revealed an immature signature of beta-cells expressing high levels of …
CD81-receptor associations--impact for hepatitis C virus entry and antiviral therapies.
Zona L, Tawar RG, Zeisel MB, Xiao F, Schuster C, Lupberger J, Baumert TF. Zona L, et al. Viruses. 2014 Feb 18;6(2):875-92. doi: 10.3390/v6020875. Viruses. 2014. PMID: 24553110 Free PMC article. Review.
Tetraspanins are integral transmembrane proteins organized in microdomains displaying specific and direct interactions with other tetraspanins and molecular partners. Among them, CD81 has been implicated in a variety of physiological and pathological processes. CD81
Tetraspanins are integral transmembrane proteins organized in microdomains displaying specific and direct interactions with other tetraspani …
Tetraspanin CD81 regulates HSV-1 infection.
Benayas B, Sastre I, López-Martín S, Oo A, Kim B, Bullido MJ, Aldudo J, Yáñez-Mó M. Benayas B, et al. Med Microbiol Immunol. 2020 Aug;209(4):489-498. doi: 10.1007/s00430-020-00684-0. Epub 2020 Jun 4. Med Microbiol Immunol. 2020. PMID: 32500359 Free PMC article.
Here we aimed at analysing the role of CD81 in Herpes simplex virus 1 infectivity using a neuroblastoma cell model. For this purpose, we generated a CD81 KO cell line using the CRISPR/Cas9 technology. Despite being CD81 a plasma membrane protein, CD81
Here we aimed at analysing the role of CD81 in Herpes simplex virus 1 infectivity using a neuroblastoma cell model. For this purpose, …
Renal CD81 interacts with sodium potassium 2 chloride cotransporter and sodium chloride cotransporter in rats with lipopolysaccharide-induced preeclampsia.
Wang P, Zhu G, Wu Q, Shen L, Liu D, Wang Z, Wang W, Ren Z, Jia Y, Liu M, Xue Y, Ji D, Hu Y, Yu Y, Wang X. Wang P, et al. FASEB J. 2023 Apr;37(4):e22834. doi: 10.1096/fj.202201546RR. FASEB J. 2023. PMID: 36961378
Expanding our prior research on placental cluster of differentiation 81 (CD81), this study explores the interaction of renal CD81 with sodium transporters in preeclampsia (PE). ...Urine CD81 with NKCC2 and NCC may be used as biomarkers for PE....
Expanding our prior research on placental cluster of differentiation 81 (CD81), this study explores the interaction of renal CD81
Differential proteomics argues against a general role for CD9, CD81 or CD63 in the sorting of proteins into extracellular vesicles.
Fan Y, Pionneau C, Cocozza F, Boëlle PY, Chardonnet S, Charrin S, Théry C, Zimmermann P, Rubinstein E. Fan Y, et al. J Extracell Vesicles. 2023 Aug;12(8):e12352. doi: 10.1002/jev2.12352. J Extracell Vesicles. 2023. PMID: 37525398 Free PMC article.
The tetraspanins CD9, CD81 and CD63 are major components of extracellular vesicles (EVs). ...In the MCF7 breast cancer cell line CD63 was as expected predominantly intracellular. In contrast CD9 and CD81 strongly colocalized at the plasma membrane, albeit with diffe …
The tetraspanins CD9, CD81 and CD63 are major components of extracellular vesicles (EVs). ...In the MCF7 breast cancer cell line CD63 …
CD81 (TAPA-1): a molecule involved in signal transduction and cell adhesion in the immune system.
Levy S, Todd SC, Maecker HT. Levy S, et al. Annu Rev Immunol. 1998;16:89-109. doi: 10.1146/annurev.immunol.16.1.89. Annu Rev Immunol. 1998. PMID: 9597125 Review.
However, CD81-deficient mice express normal numbers and subsets of T cells. ...Similarly, anti-CD81 can activate alpha L beta 2 (LFA-1) on human thymocytes. CD81 can also affect cognate B-T cell interactions because anti-CD81 increases IL-4 synthesis b …
However, CD81-deficient mice express normal numbers and subsets of T cells. ...Similarly, anti-CD81 can activate alpha L beta …
2,305 results