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Items: 1 to 20 of 167


AMPA-ergic regulation of amyloid-β levels in an Alzheimer's disease mouse model.

Hettinger JC, Lee H, Bu G, Holtzman DM, Cirrito JR.

Mol Neurodegener. 2018 May 15;13(1):22. doi: 10.1186/s13024-018-0256-6.


Intracellular trafficking of TREM2 is regulated by presenilin 1.

Zhao Y, Li X, Huang T, Jiang LL, Tan Z, Zhang M, Cheng IH, Wang X, Bu G, Zhang YW, Wang Q, Xu H.

Exp Mol Med. 2017 Dec 1;49(12):e405. doi: 10.1038/emm.2017.200.


Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2).

Zhong L, Wang Z, Wang D, Wang Z, Martens YA, Wu L, Xu Y, Wang K, Li J, Huang R, Can D, Xu H, Bu G, Chen XF.

Mol Neurodegener. 2018 Mar 27;13(1):15. doi: 10.1186/s13024-018-0247-7.


The efficacy of pregabalin for acute pain control in herpetic neuralgia patients: A meta-analysis.

Wang SL, Wang H, Nie HY, Bu G, Shen XD, Wang H.

Medicine (Baltimore). 2017 Dec;96(51):e9167. doi: 10.1097/MD.0000000000009167. Review.


Behavioral and transcriptomic analysis of Trem2-null mice: not all knockout mice are created equal.

Kang SS, Kurti A, Baker KE, Liu CC, Colonna M, Ulrich JD, Holtzman DM, Bu G, Fryer JD.

Hum Mol Genet. 2018 Jan 15;27(2):211-223. doi: 10.1093/hmg/ddx366.


Peptides from Colochirus robustus Enhance Immune Function via Activating CD3ζ- and ZAP-70-Mediated Signaling in C57BL/6 Mice.

Du X, Lian F, Li Y, Li D, Wu D, Feng Q, Feng Z, Li Y, Bu G, Meng F, Cao X, Chen Z, Zeng X.

Int J Mol Sci. 2017 Oct 8;18(10). pii: E2110. doi: 10.3390/ijms18102110.


Synaptic Adhesion Molecule Pcdh-γC5 Mediates Synaptic Dysfunction in Alzheimer's Disease.

Li Y, Chen Z, Gao Y, Pan G, Zheng H, Zhang Y, Xu H, Bu G, Zheng H.

J Neurosci. 2017 Sep 20;37(38):9259-9268. doi: 10.1523/JNEUROSCI.1051-17.2017. Epub 2017 Aug 21.


Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways.

Wojtas AM, Kang SS, Olley BM, Gatherer M, Shinohara M, Lozano PA, Liu CC, Kurti A, Baker KE, Dickson DW, Yue M, Petrucelli L, Bu G, Carare RO, Fryer JD.

Proc Natl Acad Sci U S A. 2017 Aug 15;114(33):E6962-E6971. doi: 10.1073/pnas.1701137114. Epub 2017 Jul 12.


TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway.

Zhong L, Zhang ZL, Li X, Liao C, Mou P, Wang T, Wang Z, Wang Z, Wei M, Xu H, Bu G, Chen XF.

Front Aging Neurosci. 2017 Jun 21;9:204. doi: 10.3389/fnagi.2017.00204. eCollection 2017.


The PINK1 p.I368N mutation affects protein stability and ubiquitin kinase activity.

Ando M, Fiesel FC, Hudec R, Caulfield TR, Ogaki K, Górka-Skoczylas P, Koziorowski D, Friedman A, Chen L, Dawson VL, Dawson TM, Bu G, Ross OA, Wszolek ZK, Springer W.

Mol Neurodegener. 2017 Apr 24;12(1):32. doi: 10.1186/s13024-017-0174-z.


Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition.

Liu CC, Hu J, Zhao N, Wang J, Wang N, Cirrito JR, Kanekiyo T, Holtzman DM, Bu G.

J Neurosci. 2017 Apr 12;37(15):4023-4031. doi: 10.1523/JNEUROSCI.3442-16.2017. Epub 2017 Mar 8.


Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice.

Rogers JT, Liu CC, Zhao N, Wang J, Putzke T, Yang L, Shinohara M, Fryer JD, Kanekiyo T, Bu G.

Neurobiol Aging. 2017 May;53:112-121. doi: 10.1016/j.neurobiolaging.2017.02.001. Epub 2017 Feb 9.


Soluble TREM2 induces inflammatory responses and enhances microglial survival.

Zhong L, Chen XF, Wang T, Wang Z, Liao C, Wang Z, Huang R, Wang D, Li X, Wu L, Jia L, Zheng H, Painter M, Atagi Y, Liu CC, Zhang YW, Fryer JD, Xu H, Bu G.

J Exp Med. 2017 Mar 6;214(3):597-607. doi: 10.1084/jem.20160844. Epub 2017 Feb 16.


Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism.

Nielsen HM, Chen K, Lee W, Chen Y, Bauer RJ 3rd, Reiman E, Caselli R, Bu G.

Alzheimers Res Ther. 2017 Jan 30;9(1):5. doi: 10.1186/s13195-016-0231-9.


TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway.

Zheng H, Jia L, Liu CC, Rong Z, Zhong L, Yang L, Chen XF, Fryer JD, Wang X, Zhang YW, Xu H, Bu G.

J Neurosci. 2017 Feb 15;37(7):1772-1784. doi: 10.1523/JNEUROSCI.2459-16.2017. Epub 2017 Jan 11.


Lipocalin-2 protects the brain during inflammatory conditions.

Kang SS, Ren Y, Liu CC, Kurti A, Baker KE, Bu G, Asmann Y, Fryer JD.

Mol Psychiatry. 2018 Feb;23(2):344-350. doi: 10.1038/mp.2016.243. Epub 2017 Jan 10.


SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis.

Wang X, Zhou Y, Wang J, Tseng IC, Huang T, Zhao Y, Zheng Q, Gao Y, Luo H, Zhang X, Bu G, Hong W, Xu H.

J Neurosci. 2016 Dec 14;36(50):12586-12597.


LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways.

Yang L, Liu CC, Zheng H, Kanekiyo T, Atagi Y, Jia L, Wang D, N'songo A, Can D, Xu H, Chen XF, Bu G.

J Neuroinflammation. 2016 Dec 8;13(1):304.


Comparison of 128-Slice Low-Dose Prospective ECG-Gated CT Scanning and Trans-Thoracic Echocardiography for the Diagnosis of Complex Congenital Heart Disease.

Bu G, Miao Y, Bin J, Deng S, Liu T, Jiang H, Chen W.

PLoS One. 2016 Oct 27;11(10):e0165617. doi: 10.1371/journal.pone.0165617. eCollection 2016.

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