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Page 1
Symptom Burden, Health Status, and Productivity in Patients with Uncontrolled and Controlled Severe Asthma in NOVELTY.
Ding B, Chen S, Srivastava D, Quinton A, Cook W, Papi A, Reddel HK; NOVELTY Scientific Community; NOVELTY study investigators. Ding B, et al. J Asthma Allergy. 2023 Jun 11;16:611-624. doi: 10.2147/JAA.S401445. eCollection 2023. J Asthma Allergy. 2023. PMID: 37334017 Free PMC article.
Assessment of health status included St George's Respiratory Questionnaire (SGRQ), EuroQoL 5 Dimensions 5 Levels Health Questionnaire (EQ-5D-5L) index value, and EQ-5D-5L Visual Analog Score (EQ-VAS). Assessment of productivity loss included absenteeism, presenteeis …
Assessment of health status included St George's Respiratory Questionnaire (SGRQ), EuroQoL 5 Dimensions 5 Levels Health Questionnaire (EQ- …
Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties.
Farahat AA, Kumar A, Say M, Wenzler T, Brun R, Paul A, Wilson WD, Boykin DW. Farahat AA, et al. Eur J Med Chem. 2017 Mar 10;128:70-78. doi: 10.1016/j.ejmech.2017.01.037. Epub 2017 Jan 24. Eur J Med Chem. 2017. PMID: 28152428 Free PMC article.
These compounds are shown to bind in the DNA minor groove with high affinity, and exhibit superior in vitro antitrypanosomal activity to that of DAPI. Six new diamidines (5b, 5c, 5d, 5e, 5f and 5j) exhibit superior in vivo activity to that of DAPI and four of these compoun …
These compounds are shown to bind in the DNA minor groove with high affinity, and exhibit superior in vitro antitrypanosomal activity to tha …
Synthesis and antiprotozoal activity of 2,5-bis[amidinoaryl]thiazoles.
Branowska D, Farahat AA, Kumar A, Wenzler T, Brun R, Liu Y, Wilson WD, Boykin DW. Branowska D, et al. Bioorg Med Chem. 2010 May 15;18(10):3551-8. doi: 10.1016/j.bmc.2010.03.058. Epub 2010 Mar 27. Bioorg Med Chem. 2010. PMID: 20403703 Free PMC article.
The diamidines showed strong DNA binding affinity as reflected by DeltaT(m) measurements. Four of the diamidines 5a, 5b, 5d and 5e were highly active in vitro against P. f. giving IC(50) values between 1.1 and 2.5nM. ...
The diamidines showed strong DNA binding affinity as reflected by DeltaT(m) measurements. Four of the diamidines 5a, 5b, 5d and 5e we …
Fractures of the greater trochanter following total hip replacement.
Brun OC, Maansson L. Brun OC, et al. Hip Int. 2013 Mar-Apr;23(2):143-6. doi: 10.5301/HIP.2013.10813. Epub 2013 Mar 8. Hip Int. 2013. PMID: 23543472 Free PMC article.
Patients with fractures had significantly poorer outcome on Oxford Hip score, Pain VAS, Satisfaction VAS and EQ-5D compared to THR without fractures. Greater trochanteric fracture following THR is one of the most common complications following THR. ...
Patients with fractures had significantly poorer outcome on Oxford Hip score, Pain VAS, Satisfaction VAS and EQ-5D compared to THR wi …
SWISSspine-a nationwide health technology assessment registry for balloon kyphoplasty: methodology and first results.
Diel P, Reuss W, Aghayev E, Moulin P, Röder C; SWISSspine Registry Group. Diel P, et al. Spine J. 2010 Nov;10(11):961-71. doi: 10.1016/j.spinee.2009.08.452. Epub 2009 Oct 9. Spine J. 2010. PMID: 19819192
OUTCOME MEASURES: Surgeon-administered outcome instruments were primary intervention form for BKP, implant, and follow-up form; patient self-reported measures were Euroqol-5D, North American Spine Society, and a comorbidity questionnaire. ...
OUTCOME MEASURES: Surgeon-administered outcome instruments were primary intervention form for BKP, implant, and follow-up form; patient self …
Impact of recombinant activated factor VII on health-related quality of life after intracerebral hemorrhage.
Diringer MN, Ferran JM, Broderick J, Davis S, Mayer SA, Steiner T, Brun NC, Skolnick BE, Christensen MC. Diringer MN, et al. Cerebrovasc Dis. 2007;24(2-3):219-25. doi: 10.1159/000104481. Epub 2007 Jun 28. Cerebrovasc Dis. 2007. PMID: 17630481 Clinical Trial.
Yet, the utility value (scaled 1.0 = perfect health and 0.0 = dead) associated with the composite EQ-5D demonstrated significantly better HRQoL (0.48 vs. 0.36; p = 0.01). This was also true for the EQ-5D Visual Analogue Scale score (44 vs. 36; p = 0.04). Finally, al …
Yet, the utility value (scaled 1.0 = perfect health and 0.0 = dead) associated with the composite EQ-5D demonstrated significantly be …
Synthesis and antiprotozoal activity of aza-analogues of furamidine.
Ismail MA, Brun R, Easterbrook JD, Tanious FA, Wilson WD, Boykin DW. Ismail MA, et al. J Med Chem. 2003 Oct 23;46(22):4761-9. doi: 10.1021/jm0302602. J Med Chem. 2003. PMID: 14561095
Prodrugs 6b and 6c were also prepared by methylation of the respective diamidoximes 5b and 5d. The symmetrical diamidines 14a,b were synthesized through the corresponding bis-O-acetoxyamidoxime followed by hydrogenation. ...
Prodrugs 6b and 6c were also prepared by methylation of the respective diamidoximes 5b and 5d. The symmetrical diamidines 14a,b were …
Is Total Hip Arthroplasty a Cost-Effective Option for Management of Displaced Femoral Neck Fractures? A Trial-Based Analysis of the HEALTH Study.
Axelrod D, Tarride JÉ, Ekhtiari S, Blackhouse G, Johal H, Bzovsky S, Schemitsch EH, Heels-Ansdell D, Bhandari M, Sprague S; HEALTH Investigators. Axelrod D, et al. J Orthop Trauma. 2020 Nov;34 Suppl 3:S37-S41. doi: 10.1097/BOT.0000000000001932. J Orthop Trauma. 2020. PMID: 33027164
METHODS: Health care resource utilization (HRU) and health-related quality of life (HRQoL) data were collected postoperatively and costed using publicly available databases. Using EuroQol-5 Dimensions (EQ-5D) scores, we derived quality adjusted life years (QALYs). A 1.5% d …
METHODS: Health care resource utilization (HRU) and health-related quality of life (HRQoL) data were collected postoperatively and costed us …
Unraveling quasiperiodic relaxations of transport barriers with gyrokinetic simulations of tokamak plasmas.
Strugarek A, Sarazin Y, Zarzoso D, Abiteboul J, Brun AS, Cartier-Michaud T, Dif-Pradalier G, Garbet X, Ghendrih P, Grandgirard V, Latu G, Passeron C, Thomine O. Strugarek A, et al. Phys Rev Lett. 2013 Oct 4;111(14):145001. doi: 10.1103/PhysRevLett.111.145001. Epub 2013 Oct 2. Phys Rev Lett. 2013. PMID: 24138245
The generation and dynamics of transport barriers governed by sheared poloidal flows are analyzed in flux-driven 5D gyrokinetic simulations of ion temperature gradient driven turbulence in tokamak plasmas. ...
The generation and dynamics of transport barriers governed by sheared poloidal flows are analyzed in flux-driven 5D gyrokinetic simul …
11 results