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Items: 1 to 20 of 127


SVIP regulates Z variant alpha-1 antitrypsin retro-translocation by inhibiting ubiquitin ligase gp78.

Khodayari N, Wang RL, Marek G, Krotova K, Kirst M, Liu C, Rouhani F, Brantly M.

PLoS One. 2017 Mar 16;12(3):e0172983. doi: 10.1371/journal.pone.0172983. eCollection 2017 Mar 16.


Alpha1-antitrypsin Deficiency-Increased Knowledge and Diagnostic Testing after Viewing Short Instructional Video.

Nolte JL, Ataya A, Merrill H, Childs M, Brantly M.

COPD. 2017 Feb;14(1):52-55. doi: 10.1080/15412555.2016.1245280. Epub 2016 Nov 7.


α1-Antitrypsin deficiency.

Greene CM, Marciniak SJ, Teckman J, Ferrarotti I, Brantly ML, Lomas DA, Stoller JK, McElvaney NG.

Nat Rev Dis Primers. 2016 Jul 28;2:16051. doi: 10.1038/nrdp.2016.51. Review.


Transcription factor Bcl11b sustains iNKT1 and iNKT2 cell programs, restricts iNKT17 cell program, and governs iNKT cell survival.

Uddin MN, Sultana DA, Lorentsen KJ, Cho JJ, Kirst ME, Brantly ML, Califano D, Sant'Angelo DB, Avram D.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7608-13. doi: 10.1073/pnas.1521846113. Epub 2016 Jun 21.


Alpha-1 Antitrypsin Gene Therapy Ameliorates Bone Loss in Ovariectomy-Induced Osteoporosis Mouse Model.

Akbar MA, Cao JJ, Lu Y, Nardo D, Chen MJ, Elshikha AS, Ahamed R, Brantly M, Holliday LS, Song S.

Hum Gene Ther. 2016 Sep;27(9):679-86. doi: 10.1089/hum.2016.029. Epub 2016 Jun 24.


In Situ Transplantation of Alginate Bioencapsulated Adipose Tissues Derived Stem Cells (ADSCs) via Hepatic Injection in a Mouse Model.

Chen MJ, Lu Y, Simpson NE, Beveridge MJ, Elshikha AS, Akbar MA, Tsai HY, Hinske S, Qin J, Grunwitz CR, Chen T, Brantly ML, Song S.

PLoS One. 2015 Sep 15;10(9):e0138184. doi: 10.1371/journal.pone.0138184. eCollection 2015 Sep 15.


Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism.

Wegman MP, Guo MH, Bennion DM, Shankar MN, Chrzanowski SM, Goldberg LA, Xu J, Williams TA, Lu X, Hsu SI, Anton SD, Leeuwenburgh C, Brantly ML.

Rejuvenation Res. 2015 Apr;18(2):162-72. doi: 10.1089/rej.2014.1624.


Characterising the association of latency with α(1)-antitrypsin polymerisation using a novel monoclonal antibody.

Tan L, Perez J, Mela M, Miranda E, Burling KA, Rouhani FN, DeMeo DL, Haq I, Irving JA, Ordóñez A, Dickens JA, Brantly M, Marciniak SJ, Alexander GJ, Gooptu B, Lomas DA.

Int J Biochem Cell Biol. 2015 Jan;58:81-91. doi: 10.1016/j.biocel.2014.11.005. Epub 2014 Nov 13.


TREM-1 is induced in tumor associated macrophages by cyclo-oxygenase pathway in human non-small cell lung cancer.

Yuan Z, Mehta HJ, Mohammed K, Nasreen N, Roman R, Brantly M, Sadikot RT.

PLoS One. 2014 May 19;9(5):e94241. doi: 10.1371/journal.pone.0094241. eCollection 2014 May 19.


Longer telomere length in COPD patients with α1-antitrypsin deficiency independent of lung function.

Saferali A, Lee J, Sin DD, Rouhani FN, Brantly ML, Sandford AJ.

PLoS One. 2014 Apr 24;9(4):e95600. doi: 10.1371/journal.pone.0095600. eCollection 2014 Apr 24.


Triggering receptor expressed on myeloid cells 1 (TREM-1)-mediated Bcl-2 induction prolongs macrophage survival.

Yuan Z, Syed MA, Panchal D, Joo M, Colonna M, Brantly M, Sadikot RT.

J Biol Chem. 2014 May 23;289(21):15118-29. doi: 10.1074/jbc.M113.536490. Epub 2014 Apr 7.


Circulating polymers in α1-antitrypsin deficiency.

Tan L, Dickens JA, Demeo DL, Miranda E, Perez J, Rashid ST, Day J, Ordoñez A, Marciniak SJ, Haq I, Barker AF, Campbell EJ, Eden E, McElvaney NG, Rennard SI, Sandhaus RA, Stocks JM, Stoller JK, Strange C, Turino G, Rouhani FN, Brantly M, Lomas DA.

Eur Respir J. 2014 May;43(5):1501-4. doi: 10.1183/09031936.00111213. Epub 2014 Mar 6. No abstract available.


Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study.

Manichaikul A, Hoffman EA, Smolonska J, Gao W, Cho MH, Baumhauer H, Budoff M, Austin JH, Washko GR, Carr JJ, Kaufman JD, Pottinger T, Powell CA, Wijmenga C, Zanen P, Groen HJ, Postma DS, Wanner A, Rouhani FN, Brantly ML, Powell R, Smith BM, Rabinowitz D, Raffel LJ, Hinckley Stukovsky KD, Crapo JD, Beaty TH, Hokanson JE, Silverman EK, Dupuis J, O'Connor GT, Boezen HM, Rich SS, Barr RG.

Am J Respir Crit Care Med. 2014 Feb 15;189(4):408-18. doi: 10.1164/rccm.201306-1061OC.


Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression.

Mueller C, Chulay JD, Trapnell BC, Humphries M, Carey B, Sandhaus RA, McElvaney NG, Messina L, Tang Q, Rouhani FN, Campbell-Thompson M, Fu AD, Yachnis A, Knop DR, Ye GJ, Brantly M, Calcedo R, Somanathan S, Richman LP, Vonderheide RH, Hulme MA, Brusko TM, Wilson JM, Flotte TR.

J Clin Invest. 2013 Dec;123(12):5310-8. doi: 10.1172/JCI70314. Epub 2013 Nov 15.


Reprogramming adipose tissue-derived mesenchymal stem cells into pluripotent stem cells by a mutant adeno-associated viral vector.

Chen MJ, Lu Y, Hamazaki T, Tsai HY, Erger K, Conlon T, Elshikha AS, Li H, Srivastava A, Yao C, Brantly M, Chiodo V, Hauswirth W, Terada N, Song S.

Hum Gene Ther Methods. 2014 Feb;25(1):72-82. doi: 10.1089/hgtb.2013.011. Epub 2013 Dec 28.


Serum VEGF-D a concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial.

Young L, Lee HS, Inoue Y, Moss J, Singer LG, Strange C, Nakata K, Barker AF, Chapman JT, Brantly ML, Stocks JM, Brown KK, Lynch JP 3rd, Goldberg HJ, Downey GP, Swigris JJ, Taveira-DaSilva AM, Krischer JP, Trapnell BC, McCormack FX; MILES Trial Group..

Lancet Respir Med. 2013 Aug;1(6):445-52.


Appropriateness of newborn screening for α1-antitrypsin deficiency.

Teckman J, Pardee E, Howell RR, Mannino D, Sharp RR, Brantly M, Wanner A, Lamson J; Alpha-1 Foundation Workshop Attendees..

J Pediatr Gastroenterol Nutr. 2014 Feb;58(2):199-203. doi: 10.1097/MPG.0000000000000196.


Safety and pharmacokinetics of 120 mg/kg versus 60 mg/kg weekly intravenous infusions of alpha-1 proteinase inhibitor in alpha-1 antitrypsin deficiency: a multicenter, randomized, double-blind, crossover study (SPARK).

Campos MA, Kueppers F, Stocks JM, Strange C, Chen J, Griffin R, Wang-Smith L, Brantly ML.

COPD. 2013 Dec;10(6):687-95. doi: 10.3109/15412555.2013.800852. Epub 2013 Jul 17.


Biochemical efficacy and safety of a new, ready-to-use, liquid alpha-1-proteinase inhibitor, GLASSIA (alpha1-proteinase inhibitor (human), intravenous).

Sandhaus RA, Stocks J, Rouhani FN, Brantly M, Strauss P.

COPD. 2014 Feb;11(1):17-25. doi: 10.3109/15412555.2013.804500. Epub 2013 Jul 3.


Alpha-1 antitrypsin augmentation therapy and biomarkers of elastin degradation.

Ma S, Lin YY, He J, Rouhani FN, Brantly M, Turino GM.

COPD. 2013 Aug;10(4):473-81. doi: 10.3109/15412555.2013.771163. Epub 2013 Apr 5.


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