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Items: 1 to 20 of 59


Genetic selection for mistranslation rescues a defective co-chaperone in yeast.

Hoffman KS, Berg MD, Shilton BH, Brandl CJ, O'Donoghue P.

Nucleic Acids Res. 2016 Nov 28. pii: gkw1021. [Epub ahead of print]


Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response.

Hoffman KS, Duennwald ML, Karagiannis J, Genereaux J, McCarton AS, Brandl CJ.

G3 (Bethesda). 2016 Jun 1;6(6):1649-59. doi: 10.1534/g3.116.029520.


Pin1: Intimate involvement with the regulatory protein kinase networks in the global phosphorylation landscape.

Litchfield DW, Shilton BH, Brandl CJ, Gyenis L.

Biochim Biophys Acta. 2015 Oct;1850(10):2077-86. doi: 10.1016/j.bbagen.2015.02.018. Review.


Peroxide-mediated oxidation and inhibition of the peptidyl-prolyl isomerase Pin1.

Innes BT, Sowole MA, Gyenis L, Dubinsky M, Konermann L, Litchfield DW, Brandl CJ, Shilton BH.

Biochim Biophys Acta. 2015 May;1852(5):905-12. doi: 10.1016/j.bbadis.2014.12.025.


The PS1 hairpin of Mcm3 is essential for viability and for DNA unwinding in vitro.

Lam SK, Ma X, Sing TL, Shilton BH, Brandl CJ, Davey MJ.

PLoS One. 2013 Dec 11;8(12):e82177. doi: 10.1371/journal.pone.0082177.


The C-terminal residues of Saccharomyces cerevisiae Mec1 are required for its localization, stability, and function.

DaSilva LF, Pillon S, Genereaux J, Davey MJ, Gloor GB, Karagiannis J, Brandl CJ.

G3 (Bethesda). 2013 Oct 3;3(10):1661-74. doi: 10.1534/g3.113.006841.


Non-catalytic participation of the Pin1 peptidyl-prolyl isomerase domain in target binding.

Innes BT, Bailey ML, Brandl CJ, Shilton BH, Litchfield DW.

Front Physiol. 2013 Feb 13;4:18. doi: 10.3389/fphys.2013.00018.


Mcm2 phosphorylation and the response to replicative stress.

Stead BE, Brandl CJ, Sandre MK, Davey MJ.

BMC Genet. 2012 May 7;13:36. doi: 10.1186/1471-2156-13-36.


Genetic evidence links the ASTRA protein chaperone component Tti2 to the SAGA transcription factor Tra1.

Genereaux J, Kvas S, Dobransky D, Karagiannis J, Gloor GB, Brandl CJ.

Genetics. 2012 Jul;191(3):765-80. doi: 10.1534/genetics.112.140459.


Loss of nonsense mediated decay suppresses mutations in Saccharomyces cerevisiae TRA1.

Kvas S, Gloor GB, Brandl CJ.

BMC Genet. 2012 Mar 22;13:19. doi: 10.1186/1471-2156-13-19.


A synthetic human kinase can control cell cycle progression in budding yeast.

Davey MJ, Andrighetti HJ, Ma X, Brandl CJ.

G3 (Bethesda). 2011 Sep;1(4):317-25. doi: 10.1534/g3.111.000430.


Phosphorylation of Mcm2 modulates Mcm2-7 activity and affects the cell's response to DNA damage.

Stead BE, Brandl CJ, Davey MJ.

Nucleic Acids Res. 2011 Sep 1;39(16):6998-7008. doi: 10.1093/nar/gkr371.


Discovery and characterization of a nonphosphorylated cyclic peptide inhibitor of the peptidylprolyl isomerase, Pin1.

Duncan KE, Dempsey BR, Killip LE, Adams J, Bailey ML, Lajoie GA, Litchfield DW, Brandl CJ, Shaw GS, Shilton BH.

J Med Chem. 2011 Jun 9;54(11):3854-65. doi: 10.1021/jm200156c.


Mutational analysis of the C-terminal FATC domain of Saccharomyces cerevisiae Tra1.

Hoke SM, Irina Mutiu A, Genereaux J, Kvas S, Buck M, Yu M, Gloor GB, Brandl CJ.

Curr Genet. 2010 Oct;56(5):447-65. doi: 10.1007/s00294-010-0313-3.


Functionally compensating coevolving positions are neither homoplasic nor conserved in clades.

Gloor GB, Tyagi G, Abrassart DM, Kingston AJ, Fernandes AD, Dunn SD, Brandl CJ.

Mol Biol Evol. 2010 May;27(5):1181-91. doi: 10.1093/molbev/msq004.


ATP binding and hydrolysis by Mcm2 regulate DNA binding by Mcm complexes.

Stead BE, Sorbara CD, Brandl CJ, Davey MJ.

J Mol Biol. 2009 Aug 14;391(2):301-13. doi: 10.1016/j.jmb.2009.06.038.


Requirements for E1A dependent transcription in the yeast Saccharomyces cerevisiae.

Yousef AF, Brandl CJ, Mymryk JS.

BMC Mol Biol. 2009 Apr 17;10:32. doi: 10.1186/1471-2199-10-32.


A conserved central region of yeast Ada2 regulates the histone acetyltransferase activity of Gcn5 and interacts with phospholipids.

Hoke SM, Genereaux J, Liang G, Brandl CJ.

J Mol Biol. 2008 Dec 26;384(4):743-55. doi: 10.1016/j.jmb.2008.09.088.


The dual histidine motif in the active site of Pin1 has a structural rather than catalytic role.

Bailey ML, Shilton BH, Brandl CJ, Litchfield DW.

Biochemistry. 2008 Nov 4;47(44):11481-9. doi: 10.1021/bi800964q.


Systematic genetic array analysis links the Saccharomyces cerevisiae SAGA/SLIK and NuA4 component Tra1 to multiple cellular processes.

Hoke SM, Guzzo J, Andrews B, Brandl CJ.

BMC Genet. 2008 Jul 10;9:46. doi: 10.1186/1471-2156-9-46.

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