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Items: 1 to 20 of 517


Bipolar mood state reflected in cortico-amygdala resting state connectivity: A cohort and longitudinal study.

Brady RO Jr, Margolis A, Masters GA, Keshavan M, Öngür D.

J Affect Disord. 2017 Aug 1;217:205-209. doi: 10.1016/j.jad.2017.03.043. Epub 2017 Mar 28.


Differential brain network activity across mood states in bipolar disorder.

Brady RO Jr, Tandon N, Masters GA, Margolis A, Cohen BM, Keshavan M, Öngür D.

J Affect Disord. 2017 Jan 1;207:367-376. doi: 10.1016/j.jad.2016.09.041. Epub 2016 Oct 6.


Development of a model system for neuronal dysfunction in Fabry disease.

Kaneski CR, Brady RO, Hanover JA, Schueler UH.

Mol Genet Metab. 2016 Sep;119(1-2):144-50. doi: 10.1016/j.ymgme.2016.07.010. Epub 2016 Jul 22.


State dependent cortico-amygdala circuit dysfunction in bipolar disorder.

Brady RO Jr, Masters GA, Mathew IT, Margolis A, Cohen BM, Öngür D, Keshavan M.

J Affect Disord. 2016 Sep 1;201:79-87. doi: 10.1016/j.jad.2016.04.052. Epub 2016 Apr 28.


Emergent treatments based on the pathophysiology of bipolar disorder: A selective review.

Brady RO, Keshavan M.

Asian J Psychiatr. 2015 Dec;18:15-21. doi: 10.1016/j.ajp.2015.07.017. Epub 2015 Sep 28. Review.


Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy.

Xu H, Rahimpour S, Nesvick CL, Zhang X, Ma J, Zhang M, Zhang G, Wang L, Yang C, Hong CS, Germanwala AV, Elder JB, Ray-Chaudhury A, Yao Y, Gilbert MR, Lonser RR, Heiss JD, Brady RO, Mao Y, Qin J, Zhuang Z.

Oncotarget. 2015 May 20;6(14):11882-93.


Mutant glucocerebrosidase in Gaucher disease recruits Hsp27 to the Hsp90 chaperone complex for proteasomal degradation.

Yang C, Wang H, Zhu D, Hong CS, Dmitriev P, Zhang C, Li Y, Ikejiri B, Brady RO, Zhuang Z.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1137-42. doi: 10.1073/pnas.1424288112. Epub 2015 Jan 12.


Normalization and improvement of CNS deficits in mice with Hurler syndrome after long-term peripheral delivery of BBB-targeted iduronidase.

El-Amouri SS, Dai M, Han JF, Brady RO, Pan D.

Mol Ther. 2014 Dec;22(12):2028-37. doi: 10.1038/mt.2014.152. Epub 2014 Aug 4.


Glucocerebrosidase 2 gene deletion rescues type 1 Gaucher disease.

Mistry PK, Liu J, Sun L, Chuang WL, Yuen T, Yang R, Lu P, Zhang K, Li J, Keutzer J, Stachnik A, Mennone A, Boyer JL, Jain D, Brady RO, New MI, Zaidi M.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4934-9. doi: 10.1073/pnas.1400768111. Epub 2014 Mar 17.


Platelets are efficient and protective depots for storage, distribution, and delivery of lysosomal enzyme in mice with Hurler syndrome.

Dai M, Han J, El-Amouri SS, Brady RO, Pan D.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2680-5. doi: 10.1073/pnas.1323155111. Epub 2014 Feb 3.


Position statement: National Gaucher Foundation Medical Advisory Board, January 7, 2014.

Barranger JA, Brady RO, Grabowski GA, Mankin H, Mistry PK, Weinreb NJ.

Am J Hematol. 2014 May;89(5):457-8. doi: 10.1002/ajh.23687. Epub 2014 Mar 7. No abstract available.


Celastrol increases glucocerebrosidase activity in Gaucher disease by modulating molecular chaperones.

Yang C, Swallows CL, Zhang C, Lu J, Xiao H, Brady RO, Zhuang Z.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):249-54. doi: 10.1073/pnas.1321341111. Epub 2013 Dec 18.


99mTc-sestamibi scintigraphy to monitor the long-term efficacy of enzyme replacement therapy on bone marrow infiltration in patients with Gaucher disease.

Erba PA, Minichilli F, Giona F, Linari S, Dambrosia J, Pierini A, Filocamo M, Di Rocco M, Buffoni F, Brady RO, Mariani G.

J Nucl Med. 2013 Oct;54(10):1717-24. doi: 10.2967/jnumed.113.121871. Epub 2013 Aug 29.


Are structural brain abnormalities associated with suicidal behavior in patients with psychotic disorders?

Giakoumatos CI, Tandon N, Shah J, Mathew IT, Brady RO, Clementz BA, Pearlson GD, Thaker GK, Tamminga CA, Sweeney JA, Keshavan MS.

J Psychiatr Res. 2013 Oct;47(10):1389-95. doi: 10.1016/j.jpsychires.2013.06.011. Epub 2013 Jul 15.


Histone deacetylase inhibitors are neuroprotective and preserve NGF-mediated cell survival following traumatic brain injury.

Lu J, Frerich JM, Turtzo LC, Li S, Chiang J, Yang C, Wang X, Zhang C, Wu C, Sun Z, Niu G, Zhuang Z, Brady RO, Chen X.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10747-52. doi: 10.1073/pnas.1308950110. Epub 2013 Jun 10.


Brain gamma-aminobutyric acid (GABA) abnormalities in bipolar disorder.

Brady RO Jr, McCarthy JM, Prescot AP, Jensen JE, Cooper AJ, Cohen BM, Renshaw PF, Ongür D.

Bipolar Disord. 2013 Jun;15(4):434-9. doi: 10.1111/bdi.12074. Epub 2013 May 2.


Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier.

Wang D, El-Amouri SS, Dai M, Kuan CY, Hui DY, Brady RO, Pan D.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2999-3004. doi: 10.1073/pnas.1222742110. Epub 2013 Feb 4.


Histone deacetylase inhibitors increase glucocerebrosidase activity in Gaucher disease by modulation of molecular chaperones.

Yang C, Rahimpour S, Lu J, Pacak K, Ikejiri B, Brady RO, Zhuang Z.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):966-71. doi: 10.1073/pnas.1221046110. Epub 2012 Dec 31.


A longitudinal pilot proton MRS investigation of the manic and euthymic states of bipolar disorder.

Brady RO Jr, Cooper A, Jensen JE, Tandon N, Cohen B, Renshaw P, Keshavan M, Öngür D.

Transl Psychiatry. 2012 Sep 11;2:e160. doi: 10.1038/tp.2012.84.


An innovative approach to the treatment of Gaucher disease and possibly other metabolic disorders of the brain.

Brady RO, Yang C, Zhuang Z.

J Inherit Metab Dis. 2013 May;36(3):451-4. doi: 10.1007/s10545-012-9515-9. Epub 2012 Jul 20. Review.

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