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Actas Dermosifiliogr. 2017 Oct;108(8):746-751. doi: 10.1016/j.ad.2017.04.006. Epub 2017 Jun 16.

Platelet-Rich Plasma for the Treatment of Photodamage of the Skin of the Hands.

[Article in English, Spanish]

Author information

1
Servicio de Cirugía Plástica, Hospital de Especialidades del Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.
2
Servicio de Anatomía y Patología, Hospital de Especialidades del Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.
3
Unidad de Investigación Biomédica 02, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México.
4
Unidad de Investigación Biomédica 02, Unidad Médica de Alta Especialidad, Hospital de Especialidades, Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México. Electronic address: clotilde.fuentes@gmail.com.

Abstract

BACKGROUND:

Platelet-rich plasma (PRP) provides growth factors that stimulate fibroblast activation and induce the synthesis of collagen and other components of the extracellular matrix. The objective of this study was to evaluate the effect of PRP in the treatment of photodamage of the skin of the hands.

MATERIAL AND METHODS:

Experimental study enrolling persons with photoaged skin on the dorsum of the hands (Glogau photoaging scale, type III, or Fitzpatrick wrinkle classification, type II) were included between August 2012 and January 2013. A histological comparison was made of skin biopsies taken before and after the application of PRP to the skin of the dorsum of the hands.

RESULTS:

The mean (SD) age of the 18 women enrolled was 47.9 (4.3) years. Histological analysis showed an increase in the number of fibroblasts (P<.001), number of vessels (P<.001), and collagen density (P=.27). These changes produced significant improvements in the Fitzpatrick wrinkle and elastosis scale (P<.001) and in the Glogau photoaging scale (P=.01).

CONCLUSIONS:

PRP induced a reduction in the manifestations of skin aging, including an improvement in wrinkles and elastosis.

KEYWORDS:

Factores de crecimiento; Fotodaño; Growth factors; Photodamage; Plasma rico en plaquetas; Platelet-rich plasma

PMID:
28625328
DOI:
10.1016/j.ad.2017.04.006
[Indexed for MEDLINE]

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