Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 22


Interacting amino acid replacements allow poison frogs to evolve epibatidine resistance.

Tarvin RD, Borghese CM, Sachs W, Santos JC, Lu Y, O'Connell LA, Cannatella DC, Harris RA, Zakon HH.

Science. 2017 Sep 22;357(6357):1261-1266. doi: 10.1126/science.aan5061.


Novel Molecule Exhibiting Selective Affinity for GABAA Receptor Subtypes.

Borghese CM, Herman M, Snell LD, Lawrence KJ, Lee HY, Backos DS, Vanderlinden LA, Harris RA, Roberto M, Hoffman PL, Tabakoff B.

Sci Rep. 2017 Jul 24;7(1):6230. doi: 10.1038/s41598-017-05966-x.


Mutation of the inhibitory ethanol site in GABAA ρ1 receptors promotes tolerance to ethanol-induced motor incoordination.

Blednov YA, Borghese CM, Ruiz CI, Cullins MA, Da Costa A, Osterndorff-Kahanek EA, Homanics GE, Harris RA.

Neuropharmacology. 2017 Sep 1;123:201-209. doi: 10.1016/j.neuropharm.2017.06.013. Epub 2017 Jun 13.


Identification of an Inhibitory Alcohol Binding Site in GABAA ρ1 Receptors.

Borghese CM, Ruiz CI, Lee US, Cullins MA, Bertaccini EJ, Trudell JR, Harris RA.

ACS Chem Neurosci. 2016 Jan 20;7(1):100-8. doi: 10.1021/acschemneuro.5b00246. Epub 2015 Nov 25.


The molecular pharmacology of volatile anesthetics.

Borghese CM.

Int Anesthesiol Clin. 2015 Spring;53(2):28-39. doi: 10.1097/AIA.0000000000000060. Review. No abstract available.


GABAA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice.

Blednov YA, Benavidez JM, Black M, Leiter CR, Osterndorff-Kahanek E, Johnson D, Borghese CM, Hanrahan JR, Johnston GA, Chebib M, Harris RA.

PLoS One. 2014 Jan 16;9(1):e85525. doi: 10.1371/journal.pone.0085525. eCollection 2014.


GABA(A) receptor transmembrane amino acids are critical for alcohol action: disulfide cross-linking and alkyl methanethiosulfonate labeling reveal relative location of binding sites.

Borghese CM, Hicks JA, Lapid DJ, Trudell JR, Harris RA.

J Neurochem. 2014 Feb;128(3):363-75. doi: 10.1111/jnc.12476. Epub 2013 Oct 28.


Functional validation of virtual screening for novel agents with general anesthetic action at ligand-gated ion channels.

Heusser SA, Howard RJ, Borghese CM, Cullins MA, Broemstrup T, Lee US, Lindahl E, Carlsson J, Harris RA.

Mol Pharmacol. 2013 Nov;84(5):670-8. doi: 10.1124/mol.113.087692. Epub 2013 Aug 15.


Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice.

Borghese CM, Xiong W, Oh SI, Ho A, Mihic SJ, Zhang L, Lovinger DM, Homanics GE, Eger EI 2nd, Harris RA.

Anesthesiology. 2012 Oct;117(4):765-71.


Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.

Borghese CM, Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA.

J Pharmacol Exp Ther. 2012 Feb;340(2):304-16. doi: 10.1124/jpet.111.185116. Epub 2011 Oct 28.


A transmembrane amino acid in the GABAA receptor β2 subunit critical for the actions of alcohols and anesthetics.

McCracken ML, Borghese CM, Trudell JR, Harris RA.

J Pharmacol Exp Ther. 2010 Dec;335(3):600-6. doi: 10.1124/jpet.110.170472. Epub 2010 Sep 8.


Effects of acamprosate on neuronal receptors and ion channels expressed in Xenopus oocytes.

Reilly MT, Lobo IA, McCracken LM, Borghese CM, Gong D, Horishita T, Harris RA.

Alcohol Clin Exp Res. 2008 Feb;32(2):188-96. doi: 10.1111/j.1530-0277.2007.00569.x.


Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanol.

Werner DF, Blednov YA, Ariwodola OJ, Silberman Y, Logan E, Berry RB, Borghese CM, Matthews DB, Weiner JL, Harrison NL, Harris RA, Homanics GE.

J Pharmacol Exp Ther. 2006 Oct;319(1):219-27. Epub 2006 Jun 19.


The delta subunit of gamma-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol.

Borghese CM, Stórustovu Sí, Ebert B, Herd MB, Belelli D, Lambert JJ, Marshall G, Wafford KA, Harris RA.

J Pharmacol Exp Ther. 2006 Mar;316(3):1360-8. Epub 2005 Nov 4.


Beta3-containing gamma-aminobutyric acidA receptors are not major targets for the amnesic and immobilizing actions of isoflurane.

Liao M, Sonner JM, Jurd R, Rudolph U, Borghese CM, Harris RA, Laster MJ, Eger EI 2nd.

Anesth Analg. 2005 Aug;101(2):412-8, table of contents.


Sites of excitatory and inhibitory actions of alcohols on neuronal alpha2beta4 nicotinic acetylcholine receptors.

Borghese CM, Henderson LA, Bleck V, Trudell JR, Harris RA.

J Pharmacol Exp Ther. 2003 Oct;307(1):42-52. Erratum in: J Pharmacol Exp Ther. 2004 Apr;309(1):439.


Mutation in neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes blocks ethanol action.

Borghese CM, Wang L, Bleck V, Harris RA.

Addict Biol. 2003 Sep;8(3):313-8.


Inhaled drugs of abuse enhance serotonin-3 receptor function.

Lopreato GF, Phelan R, Borghese CM, Beckstead MJ, Mihic SJ.

Drug Alcohol Depend. 2003 May 1;70(1):11-5.


Supplemental Content

Loading ...
Support Center