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Impact of Aging on the Frequency, Phenotype, and Function of CD161-Expressing T Cells.

van der Geest KSM, Kroesen BJ, Horst G, Abdulahad WH, Brouwer E, Boots AMH.

Front Immunol. 2018 Apr 19;9:752. doi: 10.3389/fimmu.2018.00752. eCollection 2018.


What is the Current Evidence for Disease Subsets in Giant Cell Arteritis?

van der Geest KSM, Sandovici M, van Sleen Y, Sanders JS, Bos NA, Abdulahad WH, Stegeman CA, Heeringa P, Rutgers A, Kallenberg CGM, Boots AMH, Brouwer E.

Arthritis Rheumatol. 2018 Apr 12. doi: 10.1002/art.40520. [Epub ahead of print] Review.


Enhanced expression of PD-1 and other activation markers by CD4+ T cells of young but not old patients with metastatic melanoma.

van den Brom RRH, van der Geest KSM, Brouwer E, Hospers GAP, Boots AMH.

Cancer Immunol Immunother. 2018 Jun;67(6):925-933. doi: 10.1007/s00262-018-2148-6. Epub 2018 Mar 15.


Checks and Balances in Autoimmune Vasculitis.

Hid Cadena R, Abdulahad WH, Hospers GAP, Wind TT, Boots AMH, Heeringa P, Brouwer E.

Front Immunol. 2018 Feb 22;9:315. doi: 10.3389/fimmu.2018.00315. eCollection 2018.


Age-Dependent Pre-Vaccination Immunity Affects the Immunogenicity of Varicella Zoster Vaccination in Middle-aged Adults.

van der Heiden M, de Rond LGH, van Zelm MC, Berbers GAM, Boots AMH, Buisman AM.

Front Immunol. 2018 Jan 23;9:46. doi: 10.3389/fimmu.2018.00046. eCollection 2018.


An Explorative Biomarker Study for Vaccine Responsiveness after a Primary Meningococcal Vaccination in Middle-Aged Adults.

van der Heiden M, Berbers GAM, Fuentes S, van Zelm MC, Boots AMH, Buisman AM.

Front Immunol. 2018 Jan 11;8:1962. doi: 10.3389/fimmu.2017.01962. eCollection 2017.


Lower antibody functionality in middle-aged adults compared to adolescents after primary meningococcal vaccination: Role of IgM.

van der Heiden M, van Ravenhorst MB, Bogaard M, Boots AMH, Berbers GAM, Buisman AM.

Exp Gerontol. 2018 May;105:101-108. doi: 10.1016/j.exger.2017.12.014. Epub 2017 Dec 26.


Decreased Immunity to Varicella Zoster Virus in Giant Cell Arteritis.

Rondaan C, van der Geest KSM, Eelsing E, Boots AMH, Bos NA, Westra J, Brouwer E.

Front Immunol. 2017 Oct 24;8:1377. doi: 10.3389/fimmu.2017.01377. eCollection 2017.


Towards precision medicine in ANCA-associated vasculitis.

van der Geest KSM, Brouwer E, Sanders JS, Sandovici M, Bos NA, Boots AMH, Abdulahad WH, Stegeman CA, Kallenberg CGM, Heeringa P, Rutgers A.

Rheumatology (Oxford). 2017 Oct 17. doi: 10.1093/rheumatology/kex367. [Epub ahead of print]


Tetanus Toxoid carrier protein induced T-helper cell responses upon vaccination of middle-aged adults.

van der Heiden M, Duizendstra A, Berbers GAM, Boots AMH, Buisman AM.

Vaccine. 2017 Oct 9;35(42):5581-5588. doi: 10.1016/j.vaccine.2017.08.056. Epub 2017 Sep 4.


Novel Intervention in the Aging Population: A Primary Meningococcal Vaccine Inducing Protective IgM Responses in Middle-Aged Adults.

van der Heiden M, Boots AMH, Bonacic Marinovic AA, de Rond LGH, van Maurik M, Tcherniaeva I, Berbers GAM, Buisman AM.

Front Immunol. 2017 Jul 19;8:817. doi: 10.3389/fimmu.2017.00817. eCollection 2017.


Involvement of Monocyte Subsets in the Immunopathology of Giant Cell Arteritis.

van Sleen Y, Wang Q, van der Geest KSM, Westra J, Abdulahad WH, Heeringa P, Boots AMH, Brouwer E.

Sci Rep. 2017 Jul 26;7(1):6553. doi: 10.1038/s41598-017-06826-4.


Ageing and latent CMV infection impact on maturation, differentiation and exhaustion profiles of T-cell receptor gammadelta T-cells.

Kallemeijn MJ, Boots AMH, van der Klift MY, Brouwer E, Abdulahad WH, Verhaar JAN, van Dongen JJM, Langerak AW.

Sci Rep. 2017 Jul 14;7(1):5509. doi: 10.1038/s41598-017-05849-1.


Artery tertiary lymphoid organs in giant cell arteritis are not exclusively located in the media of temporal arteries.

Graver JC, Sandovici M, Diepstra A, Boots AMH, Brouwer E.

Ann Rheum Dis. 2018 Mar;77(3):e16. doi: 10.1136/annrheumdis-2017-211860. Epub 2017 Jun 24. No abstract available.


Changes in peripheral immune cell numbers and functions in octogenarian walkers - an acute exercise study.

van der Geest KSM, Wang Q, Eijsvogels TMH, Koenen HJP, Joosten I, Brouwer E, Hopman MTE, Jacobs JFM, Boots AMH.

Immun Ageing. 2017 Feb 22;14:5. doi: 10.1186/s12979-017-0087-2. eCollection 2017.


Single CD28 stimulation induces stable and polyclonal expansion of human regulatory T cells.

He X, Smeets RL, van Rijssen E, Boots AM, Joosten I, Koenen HJ.

Sci Rep. 2017 Feb 22;7:43003. doi: 10.1038/srep43003.


Age-determined severity of anti-myeloperoxidase autoantibody-mediated glomerulonephritis in mice.

Wang Q, van Timmeren MM, Petersen AH, Yuan J, Moser J, Brouwer E, Westra J, Boots AM, Heeringa P.

Nephrol Dial Transplant. 2017 Feb 1;32(2):254-264. doi: 10.1093/ndt/gfw202.


Argonaute 2 immunoprecipitation revealed large tumor suppressor kinase 1 as a novel proapoptotic target of miR-21 in T cells.

Teteloshvili N, Smigielska-Czepiel K, Yuan Y, Seitz A, de Jong D, Rutgers B, Jellema P, van der Lei RJ, Slezak-Prochazka I, Brouwer E, Boots AM, Kroesen BJ, van den Berg A, Kluiver J.

FEBS J. 2017 Feb;284(4):555-567. doi: 10.1111/febs.14011. Epub 2017 Feb 6.


Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders.

Te Velde AA, Bezema T, van Kampen AH, Kraneveld AD, 't Hart BA, van Middendorp H, Hack EC, van Montfrans JM, Belzer C, Jans-Beken L, Pieters RH, Knipping K, Huber M, Boots AM, Garssen J, Radstake TR, Evers AW, Prakken BJ, Joosten I.

Front Immunol. 2016 Dec 12;7:587. doi: 10.3389/fimmu.2016.00587. eCollection 2016.


Regulatory CD4+ T-Cell Subsets and Anti-Citrullinated Protein Antibody Repertoire: Potential Biomarkers for Arthritis Development in Seropositive Arthralgia Patients?

Janssen KM, Westra J, Chalan P, Boots AM, de Smit MJ, van Winkelhoff AJ, Vissink A, Brouwer E.

PLoS One. 2016 Sep 1;11(9):e0162101. doi: 10.1371/journal.pone.0162101. eCollection 2016.

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