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Items: 1 to 20 of 329


Inducible IL-7 Hyperexpression Influences Lymphocyte Homeostasis and Function and Increases Allograft Rejection.

Schreiber M, Weigelt M, Karasinsky A, Anastassiadis K, Schallenberg S, Petzold C, Bonifacio E, Kretschmer K, Hommel A.

Front Immunol. 2019 Apr 10;10:742. doi: 10.3389/fimmu.2019.00742. eCollection 2019.


Common patterns of gene regulation associated with Cesarean section and the development of islet autoimmunity - indications of immune cell activation.

Laimighofer M, Lickert R, Fuerst R, Theis FJ, Winkler C, Bonifacio E, Ziegler AG, Krumsiek J.

Sci Rep. 2019 Apr 18;9(1):6250. doi: 10.1038/s41598-019-42750-5.


Cytoplasmic ends of tetraspanin 7 harbour epitopes recognised by autoantibodies in type 1 diabetes.

Eugster A, Kraus G, Lidzba V, Müller D, Jolink M, Ziegler AG, Bonifacio E.

Diabetologia. 2019 May;62(5):805-810. doi: 10.1007/s00125-019-4832-2. Epub 2019 Feb 21.


Automated Clinical Grade Expansion of Regulatory T Cells in a Fully Closed System.

Marín Morales JM, Münch N, Peter K, Freund D, Oelschlägel U, Hölig K, Böhm T, Flach AC, Keßler J, Bonifacio E, Bornhäuser M, Fuchs A.

Front Immunol. 2019 Feb 1;10:38. doi: 10.3389/fimmu.2019.00038. eCollection 2019.


Screening for asymptomatic β-cell autoimmunity in young children.

Ziegler AG, Hoffmann GF, Hasford J, Larsson HE, Danne T, Berner R, Penno M, Koralova A, Dunne J, Bonifacio E.

Lancet Child Adolesc Health. 2019 May;3(5):288-290. doi: 10.1016/S2352-4642(19)30028-8. Epub 2019 Feb 10. No abstract available.


Tonic Signaling and Its Effects on Lymphopoiesis of CAR-Armed Hematopoietic Stem and Progenitor Cells.

Albert S, Koristka S, Gerbaulet A, Cartellieri M, Arndt C, Feldmann A, Berndt N, Loureiro LR, von Bonin M, Ehninger G, Eugster A, Bonifacio E, Bornhäuser M, Bachmann MP, Ehninger A.

J Immunol. 2019 Mar 15;202(6):1735-1746. doi: 10.4049/jimmunol.1801004. Epub 2019 Feb 6.


Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families.

Hippich M, Beyerlein A, Hagopian WA, Krischer JP, Vehik K, Knoop J, Winker C, Toppari J, Lernmark Å, Rewers MJ, Steck AK, She JX, Akolkar B, Robertson CC, Onengut-Gumuscu S, Rich SS, Bonifacio E, Ziegler AG; TEDDY Study Group; Teddy Study Group.

Diabetes. 2019 Apr;68(4):847-857. doi: 10.2337/db18-0882. Epub 2019 Jan 17.


Association of Dendritic Cell Signatures With Autoimmune Inflammation Revealed by Single-Cell Profiling.

Ashton MP, Eugster A, Dietz S, Loebel D, Lindner A, Kuehn D, Taranko AE, Heschel B, Gavrisan A, Ziegler AG, Aringer M, Bonifacio E.

Arthritis Rheumatol. 2019 May;71(5):817-828. doi: 10.1002/art.40793. Epub 2019 Apr 6.


Time-Resolved Autoantibody Profiling Facilitates Stratification of Preclinical Type 1 Diabetes in Children.

Endesfelder D, Zu Castell W, Bonifacio E, Rewers M, Hagopian WA, She JX, Lernmark Å, Toppari J, Vehik K, Williams AJK, Yu L, Akolkar B, Krischer JP, Ziegler AG, Achenbach P; TEDDY Study Group.

Diabetes. 2019 Jan;68(1):119-130. doi: 10.2337/db18-0594. Epub 2018 Oct 10.


Blood draws up to 3% of blood volume in clinical trials are safe in children.

Peplow C, Assfalg R, Beyerlein A, Hasford J, Bonifacio E, Ziegler AG.

Acta Paediatr. 2019 May;108(5):940-944. doi: 10.1111/apa.14607. Epub 2018 Oct 30.


Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study.

Beyerlein A, Bonifacio E, Vehik K, Hippich M, Winkler C, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Rich SS, Ziegler AG; TEDDY Study Group.

J Med Genet. 2018 Oct 4. pii: jmedgenet-2018-105532. doi: 10.1136/jmedgenet-2018-105532. [Epub ahead of print]


T-cell receptor-α repertoire of CD8+ T cells following allogeneic stem cell transplantation using next-generation sequencing.

Link-Rachner CS, Eugster A, Rücker-Braun E, Heidenreich F, Oelschlägel U, Dahl A, Klesse C, Kuhn M, Middeke JM, Bornhäuser M, Bonifacio E, Schetelig J.

Haematologica. 2019 Mar;104(3):622-631. doi: 10.3324/haematol.2018.199802. Epub 2018 Sep 27.


Immunological biomarkers for the development and progression of type 1 diabetes.

Mathieu C, Lahesmaa R, Bonifacio E, Achenbach P, Tree T.

Diabetologia. 2018 Nov;61(11):2252-2258. doi: 10.1007/s00125-018-4726-8. Epub 2018 Sep 12. Review.


CD4+ T cell activation, function, and metabolism are inhibited by low concentrations of DMSO.

Holthaus L, Lamp D, Gavrisan A, Sharma V, Ziegler AG, Jastroch M, Bonifacio E.

J Immunol Methods. 2018 Dec;463:54-60. doi: 10.1016/j.jim.2018.09.004. Epub 2018 Sep 7.


Novel minor HLA DR associated antigens in type 1 diabetes.

Müller D, Telieps T, Eugster A, Weinzierl C, Jolink M, Ziegler AG, Bonifacio E.

Clin Immunol. 2018 Sep;194:87-91. doi: 10.1016/j.clim.2018.07.001. Epub 2018 Jul 7.


Searching peripheral blood mononuclear cells of children with viral respiratory tract infections preceding islet autoimmunity for viruses by high-throughput sequencing.

Hippich M, Oleynik A, Jain K, Winkler C, Ferreira RC, Bonifacio E, Ziegler AG, Briese T.

Acta Diabetol. 2018 Aug;55(8):881-884. doi: 10.1007/s00592-018-1138-7. Epub 2018 Apr 23. No abstract available.


Autoantibodies to N-terminally truncated GAD improve clinical phenotyping of individuals with adult-onset diabetes: Action LADA 12.

Achenbach P, Hawa MI, Krause S, Lampasona V, Jerram ST, Williams AJK, Bonifacio E, Ziegler AG, Leslie RD; Action LADA consortium.

Diabetologia. 2018 Jul;61(7):1644-1649. doi: 10.1007/s00125-018-4605-3. Epub 2018 Apr 4.


Genetic scores to stratify risk of developing multiple islet autoantibodies and type 1 diabetes: A prospective study in children.

Bonifacio E, Beyerlein A, Hippich M, Winkler C, Vehik K, Weedon MN, Laimighofer M, Hattersley AT, Krumsiek J, Frohnert BI, Steck AK, Hagopian WA, Krischer JP, Lernmark Å, Rewers MJ, She JX, Toppari J, Akolkar B, Oram RA, Rich SS, Ziegler AG; TEDDY Study Group.

PLoS Med. 2018 Apr 3;15(4):e1002548. doi: 10.1371/journal.pmed.1002548. eCollection 2018 Apr.


A peripheral blood transcriptomic signature predicts autoantibody development in infants at risk of type 1 diabetes.

Mehdi AM, Hamilton-Williams EE, Cristino A, Ziegler A, Bonifacio E, Le Cao KA, Harris M, Thomas R.

JCI Insight. 2018 Mar 8;3(5). pii: 98212. doi: 10.1172/jci.insight.98212.


Islet-reactive CD8+ T cell frequencies in the pancreas, but not in blood, distinguish type 1 diabetic patients from healthy donors.

Culina S, Lalanne AI, Afonso G, Cerosaletti K, Pinto S, Sebastiani G, Kuranda K, Nigi L, Eugster A, Østerbye T, Maugein A, McLaren JE, Ladell K, Larger E, Beressi JP, Lissina A, Appay V, Davidson HW, Buus S, Price DA, Kuhn M, Bonifacio E, Battaglia M, Caillat-Zucman S, Dotta F, Scharfmann R, Kyewski B, Mallone R; ImMaDiab Study Group.

Sci Immunol. 2018 Feb 2;3(20). pii: eaao4013. doi: 10.1126/sciimmunol.aao4013.

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