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Items: 14


Loss of Uhrf1 in neural stem cells leads to activation of retroviral elements and delayed neurodegeneration.

Ramesh V, Bayam E, Cernilogar FM, Bonapace IM, Schulze M, Riemenschneider MJ, Schotta G, Götz M.

Genes Dev. 2016 Oct 1;30(19):2199-2212.


DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination.

Qin W, Wolf P, Liu N, Link S, Smets M, La Mastra F, Forné I, Pichler G, Hörl D, Fellinger K, Spada F, Bonapace IM, Imhof A, Harz H, Leonhardt H.

Cell Res. 2015 Aug;25(8):911-29. doi: 10.1038/cr.2015.72. Epub 2015 Jun 12.


Inflammatory cues acting on the adult intestinal stem cells and the early onset of cancer (review).

De Lerma Barbaro A, Perletti G, Bonapace IM, Monti E.

Int J Oncol. 2014 Sep;45(3):959-68. doi: 10.3892/ijo.2014.2490. Epub 2014 Jun 10. Review.


Poly(ADP-ribose) polymerase 1 (PARP1) associates with E3 ubiquitin-protein ligase UHRF1 and modulates UHRF1 biological functions.

De Vos M, El Ramy R, Quénet D, Wolf P, Spada F, Magroun N, Babbio F, Schreiber V, Leonhardt H, Bonapace IM, Dantzer F.

J Biol Chem. 2014 Jun 6;289(23):16223-38. doi: 10.1074/jbc.M113.527424. Epub 2014 Apr 29.


Targeted DNA methylation by homology-directed repair in mammalian cells. Transcription reshapes methylation on the repaired gene.

Morano A, Angrisano T, Russo G, Landi R, Pezone A, Bartollino S, Zuchegna C, Babbio F, Bonapace IM, Allen B, Muller MT, Chiariotti L, Gottesman ME, Porcellini A, Avvedimento EV.

Nucleic Acids Res. 2014 Jan;42(2):804-21. doi: 10.1093/nar/gkt920. Epub 2013 Oct 16.


Knock-down of methyl CpG-binding protein 2 (MeCP2) causes alterations in cell proliferation and nuclear lamins expression in mammalian cells.

Babbio F, Castiglioni I, Cassina C, Gariboldi MB, Pistore C, Magnani E, Badaracco G, Monti E, Bonapace IM.

BMC Cell Biol. 2012 Jul 11;13:19. doi: 10.1186/1471-2121-13-19.


The multi-domain protein Np95 connects DNA methylation and histone modification.

Rottach A, Frauer C, Pichler G, Bonapace IM, Spada F, Leonhardt H.

Nucleic Acids Res. 2010 Apr;38(6):1796-804. doi: 10.1093/nar/gkp1152. Epub 2009 Dec 21.


Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells.

Meilinger D, Fellinger K, Bultmann S, Rothbauer U, Bonapace IM, Klinkert WE, Spada F, Leonhardt H.

EMBO Rep. 2009 Nov;10(11):1259-64. doi: 10.1038/embor.2009.201. Epub 2009 Oct 2.


The PHD domain of Np95 (mUHRF1) is involved in large-scale reorganization of pericentromeric heterochromatin.

Papait R, Pistore C, Grazini U, Babbio F, Cogliati S, Pecoraro D, Brino L, Morand AL, Dechampesme AM, Spada F, Leonhardt H, McBlane F, Oudet P, Bonapace IM.

Mol Biol Cell. 2008 Aug;19(8):3554-63. doi: 10.1091/mbc.E07-10-1059. Epub 2008 May 28.


Np95 is implicated in pericentromeric heterochromatin replication and in major satellite silencing.

Papait R, Pistore C, Negri D, Pecoraro D, Cantarini L, Bonapace IM.

Mol Biol Cell. 2007 Mar;18(3):1098-106. Epub 2006 Dec 20.


A cancer-specific transcriptional signature in human neoplasia.

Nicassio F, Bianchi F, Capra M, Vecchi M, Confalonieri S, Bianchi M, Pajalunga D, Crescenzi M, Bonapace IM, Di Fiore PP.

J Clin Invest. 2005 Nov;115(11):3015-25. Epub 2005 Oct 13.


Np95 is a histone-binding protein endowed with ubiquitin ligase activity.

Citterio E, Papait R, Nicassio F, Vecchi M, Gomiero P, Mantovani R, Di Fiore PP, Bonapace IM.

Mol Cell Biol. 2004 Mar;24(6):2526-35.


Np95 is regulated by E1A during mitotic reactivation of terminally differentiated cells and is essential for S phase entry.

Bonapace IM, Latella L, Papait R, Nicassio F, Sacco A, Muto M, Crescenzi M, Di Fiore PP.

J Cell Biol. 2002 Jun 10;157(6):909-14. Epub 2002 Jun 10.


Extinction and activation of the thyroglobulin promoter in hybrids of differentiated and transformed thyroid cells.

Bonapace IM, Sanchez M, Obici S, Gallo A, Garofalo S, Gentile R, Cocozza S, Avvedimento EV.

Mol Cell Biol. 1990 Mar;10(3):1033-40.

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