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Items: 1 to 20 of 27


Activation and cleavage of SASH1 by caspase-3 mediates an apoptotic response.

Burgess JT, Bolderson E, Adams MN, Baird AM, Zhang SD, Gately KA, Umezawa K, O'Byrne KJ, Richard DJ.

Cell Death Dis. 2016 Nov 10;7(11):e2469. doi: 10.1038/cddis.2016.364.


SASH1 mediates sensitivity of breast cancer cells to chloropyramine and is associated with prognosis in breast cancer.

Burgess JT, Bolderson E, Saunus JM, Zhang SD, Reid LE, McNicol AM, Lakhani SR, Cuff K, Richard K, Richard DJ, O'Byrne KJ.

Oncotarget. 2016 Nov 8;7(45):72807-72818. doi: 10.18632/oncotarget.12020.


Nucleophosmin: from structure and function to disease development.

Box JK, Paquet N, Adams MN, Boucher D, Bolderson E, O'Byrne KJ, Richard DJ.

BMC Mol Biol. 2016 Aug 24;17(1):19. doi: 10.1186/s12867-016-0073-9. Review.


hSSB1 (NABP2/OBFC2B) is regulated by oxidative stress.

Paquet N, Adams MN, Ashton NW, Touma C, Gamsjaeger R, Cubeddu L, Leong V, Beard S, Bolderson E, Botting CH, O'Byrne KJ, Richard DJ.

Sci Rep. 2016 Jun 8;6:27446. doi: 10.1038/srep27446.


16P The overexpression of SASH1 stimulates cell death in lung cancer cells.

O'Byrne K, Burgess J, Bolderson E, Adams M, Zhang SD, Richard D.

J Thorac Oncol. 2016 Apr;11(4 Suppl):S62-3. doi: 10.1016/S1556-0864(16)30130-7. No abstract available.


hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway.

Paquet N, Adams MN, Leong V, Ashton NW, Touma C, Gamsjaeger R, Cubeddu L, Beard S, Burgess JT, Bolderson E, O'Byrne KJ, Richard DJ.

Nucleic Acids Res. 2015 Oct 15;43(18):8817-29. doi: 10.1093/nar/gkv790.


ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.

Kijas AW, Lim YC, Bolderson E, Cerosaletti K, Gatei M, Jakob B, Tobias F, Taucher-Scholz G, Gueven N, Oakley G, Concannon P, Wolvetang E, Khanna KK, Wiesmüller L, Lavin MF.

Nucleic Acids Res. 2015 Sep 30;43(17):8352-67. doi: 10.1093/nar/gkv754.


Néstor-Guillermo Progeria Syndrome: a biochemical insight into Barrier-to-Autointegration Factor 1, alanine 12 threonine mutation.

Paquet N, Box JK, Ashton NW, Suraweera A, Croft LV, Urquhart AJ, Bolderson E, Zhang SD, O'Byrne KJ, Richard DJ.

BMC Mol Biol. 2014 Dec 12;15:27. doi: 10.1186/s12867-014-0027-z.


Rad51 supports triple negative breast cancer metastasis.

Wiegmans AP, Al-Ejeh F, Chee N, Yap PY, Gorski JJ, Da Silva L, Bolderson E, Chenevix-Trench G, Anderson R, Simpson PT, Lakhani SR, Khanna KK.

Oncotarget. 2014 May 30;5(10):3261-72.


Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising.

Jekimovs C, Bolderson E, Suraweera A, Adams M, O'Byrne KJ, Richard DJ.

Front Oncol. 2014 Apr 22;4:86. doi: 10.3389/fonc.2014.00086. Review.


Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks.

Bolderson E, Petermann E, Croft L, Suraweera A, Pandita RK, Pandita TK, Helleday T, Khanna KK, Richard DJ.

Nucleic Acids Res. 2014 Jun;42(10):6326-36. doi: 10.1093/nar/gku276.


Human single-stranded DNA binding proteins are essential for maintaining genomic stability.

Ashton NW, Bolderson E, Cubeddu L, O'Byrne KJ, Richard DJ.

BMC Mol Biol. 2013 Apr 1;14:9. doi: 10.1186/1471-2199-14-9. Review.


Kruppel-associated Box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1β (HP1-β) mobilization and DNA repair in heterochromatin.

Bolderson E, Savage KI, Mahen R, Pisupati V, Graham ME, Richard DJ, Robinson PJ, Venkitaraman AR, Khanna KK.

J Biol Chem. 2012 Aug 10;287(33):28122-31. doi: 10.1074/jbc.M112.368381.


Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions.

Tomimatsu N, Mukherjee B, Deland K, Kurimasa A, Bolderson E, Khanna KK, Burma S.

DNA Repair (Amst). 2012 Apr 1;11(4):441-8. doi: 10.1016/j.dnarep.2012.01.006.


hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity.

Richard DJ, Cubeddu L, Urquhart AJ, Bain A, Bolderson E, Menon D, White MF, Khanna KK.

Nucleic Acids Res. 2011 May;39(9):3643-51. doi: 10.1093/nar/gkq1340.


hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex.

Richard DJ, Savage K, Bolderson E, Cubeddu L, So S, Ghita M, Chen DJ, White MF, Richard K, Prise KM, Schettino G, Khanna KK.

Nucleic Acids Res. 2011 Mar;39(5):1692-702. doi: 10.1093/nar/gkq1098.


Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.

Bolderson E, Tomimatsu N, Richard DJ, Boucher D, Kumar R, Pandita TK, Burma S, Khanna KK.

Nucleic Acids Res. 2010 Apr;38(6):1821-31. doi: 10.1093/nar/gkp1164.


Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair.

Bolderson E, Richard DJ, Zhou BB, Khanna KK.

Clin Cancer Res. 2009 Oct 15;15(20):6314-20. doi: 10.1158/1078-0432.CCR-09-0096. Review.


SECIS-binding protein 2 promotes cell survival by protecting against oxidative stress.

Papp LV, Lu J, Bolderson E, Boucher D, Singh R, Holmgren A, Khanna KK.

Antioxid Redox Signal. 2010 Apr 1;12(7):797-808. doi: 10.1089/ars.2009.2913.


INTS3 controls the hSSB1-mediated DNA damage response.

Skaar JR, Richard DJ, Saraf A, Toschi A, Bolderson E, Florens L, Washburn MP, Khanna KK, Pagano M.

J Cell Biol. 2009 Oct 5;187(1):25-32. doi: 10.1083/jcb.200907026.

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