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Items: 12


Translational Dysregulation in Cancer: Molecular Insights and Potential Clinical Applications in Biomarker Development.

Vaklavas C, Blume SW, Grizzle WE.

Front Oncol. 2017 Jul 26;7:158. doi: 10.3389/fonc.2017.00158. eCollection 2017. Review.


IRES inhibition induces terminal differentiation and synchronized death in triple-negative breast cancer and glioblastoma cells.

Vaklavas C, Grizzle WE, Choi H, Meng Z, Zinn KR, Shrestha K, Blume SW.

Tumour Biol. 2016 Oct;37(10):13247-13264. Epub 2016 Jul 26.


Physiological Expression and Accumulation of the Products of Two Upstream Open Reading Frames mrtl and MycHex1 Along With p64 and p67 Myc From the Human c-myc Locus.

Ji MH, Kim SK, Kim CY, Phi JH, Jun HJ, Blume SW, Choi HS.

J Cell Biochem. 2016 Jun;117(6):1407-18. doi: 10.1002/jcb.25431. Epub 2015 Dec 2.


Small molecule inhibitors of IRES-mediated translation.

Vaklavas C, Meng Z, Choi H, Grizzle WE, Zinn KR, Blume SW.

Cancer Biol Ther. 2015;16(10):1471-85. doi: 10.1080/15384047.2015.1071729. Epub 2015 Jul 15.


Northwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation of the IGF1R IRES.

Blume SW, Jackson NL, Frost AR, Grizzle WE, Shcherbakov OD, Choi H, Meng Z.

Exp Mol Pathol. 2010 Jun;88(3):341-52. doi: 10.1016/j.yexmp.2010.03.006. Epub 2010 Mar 15.


mrtl-A translation/localization regulatory protein encoded within the human c-myc locus and distributed throughout the endoplasmic and nucleoplasmic reticular network.

Choi H, Jackson NL, Shaw DR, Emanuel PD, Liu YL, Tousson A, Meng Z, Blume SW.

J Cell Biochem. 2008 Nov 1;105(4):1092-108. doi: 10.1002/jcb.21909.


The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation.

Meng Z, King PH, Nabors LB, Jackson NL, Chen CY, Emanuel PD, Blume SW.

Nucleic Acids Res. 2005 May 24;33(9):2962-79. Print 2005.


Inhibition of tumorigenicity by the 5'-untranslated RNA of the human c-myc P0 transcript.

Blume SW, Miller DM, Guarcello V, Shrestha K, Meng Z, Snyder RC, Grizzle WE, Ruppert JM, Gartland GL, Stockard CR, Jones DE Jr, Emanuel PD.

Exp Cell Res. 2003 Aug 1;288(1):131-42.


Evidence for differential ribonucleoprotein complex assembly in vitro on the 5'-untranslated region of the human IGF-IR transcript.

Meng Z, Snyder RC, Shrestha K, Miller DM, Emanuel PD, Blume SW.

Mol Cell Endocrinol. 2003 Feb 28;200(1-2):127-40.


The 5'-untranslated RNA of the human dhfr minor transcript alters transcription pre-initiation complex assembly at the major (core) promoter.

Blume SW, Meng Z, Shrestha K, Snyder RC, Emanuel PD.

J Cell Biochem. 2003 Jan 1;88(1):165-80.


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