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Items: 1 to 20 of 250

1.

Leishmania Lipophosphoglycan Triggers Caspase-11 and the Non-canonical Activation of the NLRP3 Inflammasome.

de Carvalho RVH, Andrade WA, Lima-Junior DS, Dilucca M, de Oliveira CV, Wang K, Nogueira PM, Rugani JN, Soares RP, Beverley SM, Shao F, Zamboni DS.

Cell Rep. 2019 Jan 8;26(2):429-437.e5. doi: 10.1016/j.celrep.2018.12.047.

2.

TLR2 Signaling in Skin Nonhematopoietic Cells Induces Early Neutrophil Recruitment in Response to Leishmania major Infection.

Ronet C, Passelli K, Charmoy M, Scarpellino L, Myburgh E, Hauyon La Torre Y, Turco S, Mottram JC, Fasel N, Luther SA, Beverley SM, Launois P, Tacchini-Cottier F.

J Invest Dermatol. 2018 Dec 27. pii: S0022-202X(18)01302-7. doi: 10.1016/j.jid.2018.12.012. [Epub ahead of print]

PMID:
30594488
3.

SODB1 is essential for Leishmania major infection of macrophages and pathogenesis in mice.

Davenport BJ, Martin CG, Beverley SM, Orlicky DJ, Vazquez-Torres A, Morrison TE.

PLoS Negl Trop Dis. 2018 Oct 29;12(10):e0006921. doi: 10.1371/journal.pntd.0006921. eCollection 2018 Oct.

4.

Importance of polyphosphate in the Leishmania life cycle.

Kohl K, Zangger H, Rossi M, Isorce N, Lye LF, Owens KL, Beverley SM, Mayer A, Fasel N.

Microb Cell. 2018 Jun 22;5(8):371-384. doi: 10.15698/mic2018.08.642.

5.

Concentration of 2'C-methyladenosine triphosphate by Leishmania guyanensis enables specific inhibition of Leishmania RNA virus 1 via its RNA polymerase.

Robinson JI, Beverley SM.

J Biol Chem. 2018 Apr 27;293(17):6460-6469. doi: 10.1074/jbc.RA117.001515. Epub 2018 Mar 6.

PMID:
29511088
6.

Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β.

Hartley MA, Eren RO, Rossi M, Prevel F, Castiglioni P, Isorce N, Desponds C, Lye LF, Beverley SM, Drexler SK, Fasel N.

Microb Cell. 2018 Jan 14;5(3):137-149. doi: 10.15698/mic2018.03.619.

7.

Spontaneous excision and facilitated recovery as a control for phenotypes arising from RNA interference and other dominant transgenes.

Brettmann EA, Lye LF, Beverley SM.

Mol Biochem Parasitol. 2018 Mar;220:42-45. doi: 10.1016/j.molbiopara.2018.01.004. Epub 2018 Feb 3.

8.

Viral discovery and diversity in trypanosomatid protozoa with a focus on relatives of the human parasite Leishmania.

Grybchuk D, Akopyants NS, Kostygov AY, Konovalovas A, Lye LF, Dobson DE, Zangger H, Fasel N, Butenko A, Frolov AO, Votýpka J, d'Avila-Levy CM, Kulich P, Moravcová J, Plevka P, Rogozin IB, Serva S, Lukeš J, Beverley SM, Yurchenko V.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E506-E515. doi: 10.1073/pnas.1717806115. Epub 2017 Dec 28.

9.

Development of a semi-automated image-based high-throughput drug screening system.

Eren RO, Kopelyanskiy D, Moreau D, Chapalay JB, Chambon M, Turcatti G, Lye LF, Beverley SM, Fasel N.

Front Biosci (Elite Ed). 2018 Jan 1;10:242-253.

10.

Gene Expression in Leishmania Is Regulated Predominantly by Gene Dosage.

Iantorno SA, Durrant C, Khan A, Sanders MJ, Beverley SM, Warren WC, Berriman M, Sacks DL, Cotton JA, Grigg ME.

MBio. 2017 Sep 12;8(5). pii: e01393-17. doi: 10.1128/mBio.01393-17.

11.

Genetic metabolic complementation establishes a requirement for GDP-fucose in Leishmania.

Guo H, Novozhilova NM, Bandini G, Turco SJ, Ferguson MAJ, Beverley SM.

J Biol Chem. 2017 Jun 23;292(25):10696-10708. doi: 10.1074/jbc.M117.778480. Epub 2017 May 2.

12.

Type I interferons induced by endogenous or exogenous viral infections promote metastasis and relapse of leishmaniasis.

Rossi M, Castiglioni P, Hartley MA, Eren RO, Prével F, Desponds C, Utzschneider DT, Zehn D, Cusi MG, Kuhlmann FM, Beverley SM, Ronet C, Fasel N.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):4987-4992. doi: 10.1073/pnas.1621447114. Epub 2017 Apr 24.

13.

The Evolutionary Loss of RNAi Key Determinants in Kinetoplastids as a Multiple Sporadic Phenomenon.

Matveyev AV, Alves JM, Serrano MG, Lee V, Lara AM, Barton WA, Costa-Martins AG, Beverley SM, Camargo EP, Teixeira MM, Buck GA.

J Mol Evol. 2017 Mar;84(2-3):104-115. doi: 10.1007/s00239-017-9780-1. Epub 2017 Feb 16.

14.

Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid.

Castiglioni P, Hartley MA, Rossi M, Prevel F, Desponds C, Utzschneider DT, Eren RO, Zangger H, Brunner L, Collin N, Zehn D, Kuhlmann FM, Beverley SM, Fasel N, Ronet C.

PLoS Negl Trop Dis. 2017 Jan 18;11(1):e0005240. doi: 10.1371/journal.pntd.0005240. eCollection 2017 Jan.

15.

Antiviral screening identifies adenosine analogs targeting the endogenous dsRNA Leishmania RNA virus 1 (LRV1) pathogenicity factor.

Kuhlmann FM, Robinson JI, Bluemling GR, Ronet C, Fasel N, Beverley SM.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E811-E819. doi: 10.1073/pnas.1619114114. Epub 2017 Jan 17.

16.

Continual renewal and replication of persistent Leishmania major parasites in concomitantly immune hosts.

Mandell MA, Beverley SM.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E801-E810. doi: 10.1073/pnas.1619265114. Epub 2017 Jan 17.

17.

Atypical Manifestations of Cutaneous Leishmaniasis in a Region Endemic for Leishmania braziliensis: Clinical, Immunological and Parasitological Aspects.

Guimarães LH, Queiroz A, Silva JA, Silva SC, Magalhães V, Lago EL, Machado PR, Bacellar O, Wilson ME, Beverley SM, Carvalho EM, Schriefer A.

PLoS Negl Trop Dis. 2016 Dec 1;10(12):e0005100. doi: 10.1371/journal.pntd.0005100. eCollection 2016 Dec.

18.

Tilting the balance between RNA interference and replication eradicates Leishmania RNA virus 1 and mitigates the inflammatory response.

Brettmann EA, Shaik JS, Zangger H, Lye LF, Kuhlmann FM, Akopyants NS, Oschwald DM, Owens KL, Hickerson SM, Ronet C, Fasel N, Beverley SM.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):11998-12005. Epub 2016 Oct 18.

19.

Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A.

Hartley MA, Bourreau E, Rossi M, Castiglioni P, Eren RO, Prevel F, Couppié P, Hickerson SM, Launois P, Beverley SM, Ronet C, Fasel N.

PLoS Pathog. 2016 Sep 22;12(9):e1005852. doi: 10.1371/journal.ppat.1005852. eCollection 2016 Sep.

20.

Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence.

Eren RO, Reverte M, Rossi M, Hartley MA, Castiglioni P, Prevel F, Martin R, Desponds C, Lye LF, Drexler SK, Reith W, Beverley SM, Ronet C, Fasel N.

Cell Host Microbe. 2016 Sep 14;20(3):318-328. doi: 10.1016/j.chom.2016.08.001. Epub 2016 Sep 1.

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