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Items: 1 to 20 of 70


Actin-based protrusions of migrating neutrophils are intrinsically lamellar and facilitate direction changes.

Fritz-Laylin LK, Riel-Mehan M, Chen BC, Lord SJ, Goddard TD, Ferrin TE, Nicholson-Dykstra SM, Higgs H, Johnson GT, Betzig E, Mullins RD.

Elife. 2017 Sep 26;6. pii: e26990. doi: 10.7554/eLife.26990.


Contractile actomyosin arcs promote the activation of primary mouse T cells in a ligand-dependent manner.

Hong J, Murugesan S, Betzig E, Hammer JA.

PLoS One. 2017 Aug 17;12(8):e0183174. doi: 10.1371/journal.pone.0183174. eCollection 2017.


Cytoskeletal actin dynamics shape a ramifying actin network underpinning immunological synapse formation.

Fritzsche M, Fernandes RA, Chang VT, Colin-York H, Clausen MP, Felce JH, Galiani S, Erlenkämper C, Santos AM, Heddleston JM, Pedroza-Pacheco I, Waithe D, de la Serna JB, Lagerholm BC, Liu TL, Chew TL, Betzig E, Davis SJ, Eggeling C.

Sci Adv. 2017 Jun 21;3(6):e1603032. doi: 10.1126/sciadv.1603032. eCollection 2017 Jun.


Applying systems-level spectral imaging and analysis to reveal the organelle interactome.

Valm AM, Cohen S, Legant WR, Melunis J, Hershberg U, Wait E, Cohen AR, Davidson MW, Betzig E, Lippincott-Schwartz J.

Nature. 2017 Jun 1;546(7656):162-167. doi: 10.1038/nature22369. Epub 2017 May 24.


Visualizing dynamic microvillar search and stabilization during ligand detection by T cells.

Cai E, Marchuk K, Beemiller P, Beppler C, Rubashkin MG, Weaver VM, Gérard A, Liu TL, Chen BC, Betzig E, Bartumeus F, Krummel MF.

Science. 2017 May 12;356(6338). pii: eaal3118. doi: 10.1126/science.aal3118.


Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules.

Han X, Li P, Yang Z, Huang X, Wei G, Sun Y, Kang X, Hu X, Deng Q, Chen L, He A, Huo Y, Li D, Betzig E, Luo J.

Nat Commun. 2017 Mar 3;8:14639. doi: 10.1038/ncomms14639.


Self-organizing actin patterns shape membrane architecture but not cell mechanics.

Fritzsche M, Li D, Colin-York H, Chang VT, Moeendarbary E, Felce JH, Sezgin E, Charras G, Betzig E, Eggeling C.

Nat Commun. 2017 Feb 13;8:14347. doi: 10.1038/ncomms14347.


Actin dynamics and competition for myosin monomer govern the sequential amplification of myosin filaments.

Beach JR, Bruun KS, Shao L, Li D, Swider Z, Remmert K, Zhang Y, Conti MA, Adelstein RS, Rusan NM, Betzig E, Hammer JA.

Nat Cell Biol. 2017 Feb;19(2):85-93. doi: 10.1038/ncb3463. Epub 2017 Jan 23.


A plasma membrane template for macropinocytic cups.

Veltman DM, Williams TD, Bloomfield G, Chen BC, Betzig E, Insall RH, Kay RR.

Elife. 2016 Dec 13;5. pii: e20085. doi: 10.7554/eLife.20085.


Engulfed cadherin fingers are polarized junctional structures between collectively migrating endothelial cells.

Hayer A, Shao L, Chung M, Joubert LM, Yang HW, Tsai FC, Bisaria A, Betzig E, Meyer T.

Nat Cell Biol. 2016 Dec;18(12):1311-1323. doi: 10.1038/ncb3438. Epub 2016 Nov 14.


Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy.

Aguet F, Upadhyayula S, Gaudin R, Chou YY, Cocucci E, He K, Chen BC, Mosaliganti K, Pasham M, Skillern W, Legant WR, Liu TL, Findlay G, Marino E, Danuser G, Megason S, Betzig E, Kirchhausen T.

Mol Biol Cell. 2016 Nov 7;27(22):3418-3435. Epub 2016 Aug 17.


Formin-generated actomyosin arcs propel T cell receptor microcluster movement at the immune synapse.

Murugesan S, Hong J, Yi J, Li D, Beach JR, Shao L, Meinhardt J, Madison G, Wu X, Betzig E, Hammer JA.

J Cell Biol. 2016 Nov 7;215(3):383-399. Epub 2016 Oct 31.


V-1 regulates capping protein activity in vivo.

Jung G, Alexander CJ, Wu XS, Piszczek G, Chen BC, Betzig E, Hammer JA.

Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):E6610-E6619. Epub 2016 Oct 10.


Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER.

Nixon-Abell J, Obara CJ, Weigel AV, Li D, Legant WR, Xu CS, Pasolli HA, Harvey K, Hess HF, Betzig E, Blackstone C, Lippincott-Schwartz J.

Science. 2016 Oct 28;354(6311). pii: aaf3928. Epub 2016 Oct 27.


Highly photostable, reversibly photoswitchable fluorescent protein with high contrast ratio for live-cell superresolution microscopy.

Zhang X, Zhang M, Li D, He W, Peng J, Betzig E, Xu P.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10364-9. doi: 10.1073/pnas.1611038113. Epub 2016 Aug 25.


Real-time imaging of Huntingtin aggregates diverting target search and gene transcription.

Li L, Liu H, Dong P, Li D, Legant WR, Grimm JB, Lavis LD, Betzig E, Tjian R, Liu Z.

Elife. 2016 Aug 3;5. pii: e17056. doi: 10.7554/eLife.17056.


Flagellar membrane fusion and protein exchange in trypanosomes; a new form of cell-cell communication?

Imhof S, Fragoso C, Hemphill A, von Schubert C, Li D, Legant W, Betzig E, Roditi I.

F1000Res. 2016 Apr 14;5:682. doi: 10.12688/f1000research.8249.1. eCollection 2016.


Response to Comment on "Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics".

Li D, Betzig E.

Science. 2016 Apr 29;352(6285):527. doi: 10.1126/science.aad8396. Epub 2016 Apr 28.


High-density three-dimensional localization microscopy across large volumes.

Legant WR, Shao L, Grimm JB, Brown TA, Milkie DE, Avants BB, Lavis LD, Betzig E.

Nat Methods. 2016 Apr;13(4):359-65. doi: 10.1038/nmeth.3797. Epub 2016 Mar 7.


Three-dimensional tracking of plus-tips by lattice light-sheet microscopy permits the quantification of microtubule growth trajectories within the mitotic apparatus.

Yamashita N, Morita M, Legant WR, Chen BC, Betzig E, Yokota H, Mimori-Kiyosue Y.

J Biomed Opt. 2015 Oct;20(10):101206. doi: 10.1117/1.JBO.20.10.101206.


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