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Items: 1 to 20 of 76


Thiamine and benfotiamine improve cognition and ameliorate GSK-3β-associated stress-induced behaviours in mice.

Markova N, Bazhenova N, Anthony DC, Vignisse J, Svistunov A, Lesch KP, Bettendorff L, Strekalova T.

Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75:148-156. doi: 10.1016/j.pnpbp.2016.11.001. Epub 2016 Nov 5.


Cellular thiamine status is coupled to function of mitochondrial 2-oxoglutarate dehydrogenase.

Mkrtchyan G, Graf A, Bettendorff L, Bunik V.

Neurochem Int. 2016 Dec;101:66-75. doi: 10.1016/j.neuint.2016.10.009. Epub 2016 Oct 20.


Inhibition of mitochondrial 2-oxoglutarate dehydrogenase impairs viability of cancer cells in a cell-specific metabolism-dependent manner.

Bunik VI, Mkrtchyan G, Grabarska A, Oppermann H, Daloso D, Araujo WL, Juszczak M, Rzeski W, Bettendorff L, Fernie AR, Meixensberger J, Stepulak A, Gaunitz F.

Oncotarget. 2016 May 3;7(18):26400-21. doi: 10.18632/oncotarget.8387.


Molecular mechanisms of the non-coenzyme action of thiamin in brain: biochemical, structural and pathway analysis.

Mkrtchyan G, Aleshin V, Parkhomenko Y, Kaehne T, Di Salvo ML, Parroni A, Contestabile R, Vovk A, Bettendorff L, Bunik V.

Sci Rep. 2015 Jul 27;5:12583. doi: 10.1038/srep12583.


Thiamine triphosphate: a ubiquitous molecule in search of a physiological role.

Bettendorff L, Lakaye B, Kohn G, Wins P.

Metab Brain Dis. 2014 Dec;29(4):1069-82. doi: 10.1007/s11011-014-9509-4. Epub 2014 Mar 4. Review.


Thiamine triphosphatase and the CYTH superfamily of proteins.

Bettendorff L, Wins P.

FEBS J. 2013 Dec;280(24):6443-55. doi: 10.1111/febs.12498. Epub 2013 Sep 10. Review.


Concomitant manipulation of murine NMDA- and AMPA-receptors to produce pro-cognitive drug effects in mice.

Vignisse J, Steinbusch HW, Grigoriev V, Bolkunov A, Proshin A, Bettendorff L, Bachurin S, Strekalova T.

Eur Neuropsychopharmacol. 2014 Feb;24(2):309-20. doi: 10.1016/j.euroneuro.2013.06.010. Epub 2013 Aug 7.


Structural determinants of specificity and catalytic mechanism in mammalian 25-kDa thiamine triphosphatase.

Delvaux D, Kerff F, Murty MR, Lakaye B, Czerniecki J, Kohn G, Wins P, Herman R, Gabelica V, Heuze F, Tordoir X, Marée R, Matagne A, Charlier P, De Pauw E, Bettendorff L.

Biochim Biophys Acta. 2013 Oct;1830(10):4513-23. doi: 10.1016/j.bbagen.2013.05.014. Epub 2013 May 22.


An alternative role of FoF1-ATP synthase in Escherichia coli: synthesis of thiamine triphosphate.

Gigliobianco T, Gangolf M, Lakaye B, Pirson B, von Ballmoos C, Wins P, Bettendorff L.

Sci Rep. 2013;3:1071. doi: 10.1038/srep01071. Epub 2013 Jan 15.


Consequences of the α-ketoglutarate dehydrogenase inhibition for neuronal metabolism and survival: implications for neurodegenerative diseases.

Trofimova LK, Araújo WL, Strokina AA, Fernie AR, Bettendorff L, Bunik VI.

Curr Med Chem. 2012;19(34):5895-906.


High inorganic triphosphatase activities in bacteria and mammalian cells: identification of the enzymes involved.

Kohn G, Delvaux D, Lakaye B, Servais AC, Scholer G, Fillet M, Elias B, Derochette JM, Crommen J, Wins P, Bettendorff L.

PLoS One. 2012;7(9):e43879. doi: 10.1371/journal.pone.0043879. Epub 2012 Sep 12.


Up-regulation of 2-oxoglutarate dehydrogenase as a stress response.

Graf A, Trofimova L, Loshinskaja A, Mkrtchyan G, Strokina A, Lovat M, Tylicky A, Strumilo S, Bettendorff L, Bunik VI.

Int J Biochem Cell Biol. 2013 Jan;45(1):175-89. doi: 10.1016/j.biocel.2012.07.002. Epub 2012 Jul 17.


Overexpression of CD39 in mouse airways promotes bacteria-induced inflammation.

Théâtre E, Frederix K, Guilmain W, Delierneux C, Lecut C, Bettendorff L, Bours V, Oury C.

J Immunol. 2012 Aug 15;189(4):1966-74. doi: 10.4049/jimmunol.1102600. Epub 2012 Jul 16.


A specific inorganic triphosphatase from Nitrosomonas europaea: structure and catalytic mechanism.

Delvaux D, Murty MR, Gabelica V, Lakaye B, Lunin VV, Skarina T, Onopriyenko O, Kohn G, Wins P, De Pauw E, Bettendorff L.

J Biol Chem. 2011 Sep 30;286(39):34023-35. doi: 10.1074/jbc.M111.233585. Epub 2011 Aug 12.


The effect of thiamin tetrahydrofurfuryl disulfide on behavior of juvenile DBA/2J mice.

Hills JI, Golub MS, Bettendorff L, Keen CL.

Neurotoxicol Teratol. 2012 Mar;34(2):242-52. doi: 10.1016/ Epub 2011 Jul 24.


Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells.

Gangolf M, Czerniecki J, Radermecker M, Detry O, Nisolle M, Jouan C, Martin D, Chantraine F, Lakaye B, Wins P, Grisar T, Bettendorff L.

PLoS One. 2010 Oct 25;5(10):e13616. doi: 10.1371/journal.pone.0013616.


Adenosine thiamine triphosphate accumulates in Escherichia coli cells in response to specific conditions of metabolic stress.

Gigliobianco T, Lakaye B, Wins P, El Moualij B, Zorzi W, Bettendorff L.

BMC Microbiol. 2010 May 21;10:148. doi: 10.1186/1471-2180-10-148.


Thiamine triphosphate synthesis in rat brain occurs in mitochondria and is coupled to the respiratory chain.

Gangolf M, Wins P, Thiry M, El Moualij B, Bettendorff L.

J Biol Chem. 2010 Jan 1;285(1):583-94. doi: 10.1074/jbc.M109.054379. Epub 2009 Nov 11.


Thiamin diphosphate in biological chemistry: new aspects of thiamin metabolism, especially triphosphate derivatives acting other than as cofactors.

Bettendorff L, Wins P.

FEBS J. 2009 Jun;276(11):2917-25. doi: 10.1111/j.1742-4658.2009.07019.x. Epub 2009 Apr 23. Review.


Thiaminylated adenine nucleotides. Chemical synthesis, structural characterization and natural occurrence.

Frédérich M, Delvaux D, Gigliobianco T, Gangolf M, Dive G, Mazzucchelli G, Elias B, De Pauw E, Angenot L, Wins P, Bettendorff L.

FEBS J. 2009 Jun;276(12):3256-68. doi: 10.1111/j.1742-4658.2009.07040.x. Epub 2009 Apr 29.

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