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Items: 1 to 20 of 63


Discovery of a Potent, Selective, and Brain-Penetrant Small Molecule that Activates the Orphan Receptor GPR88 and Reduces Alcohol Intake.

Jin C, Decker AM, Makhijani VH, Besheer J, Darcq E, Kieffer BL, Maitra R.

J Med Chem. 2018 Aug 9;61(15):6748-6758. doi: 10.1021/acs.jmedchem.8b00566. Epub 2018 Jul 30.


Silencing the insular-striatal circuit decreases alcohol self-administration and increases sensitivity to alcohol.

Jaramillo AA, Van Voorhies K, Randall PA, Besheer J.

Behav Brain Res. 2018 Aug 1;348:74-81. doi: 10.1016/j.bbr.2018.04.007. Epub 2018 Apr 13.


Histone deacetylases mediate GABAA receptor expression, physiology, and behavioral maladaptations in rat models of alcohol dependence.

Bohnsack JP, Hughes BA, O'Buckley TK, Edokpolor K, Besheer J, Morrow AL.

Neuropsychopharmacology. 2018 Jun;43(7):1518-1529. doi: 10.1038/s41386-018-0034-8. Epub 2018 Feb 27.


Functional role for cortical-striatal circuitry in modulating alcohol self-administration.

Jaramillo AA, Randall PA, Stewart S, Fortino B, Van Voorhies K, Besheer J.

Neuropharmacology. 2018 Mar 1;130:42-53. doi: 10.1016/j.neuropharm.2017.11.035. Epub 2017 Nov 26.


Functional role for suppression of the insular-striatal circuit in modulating interoceptive effects of alcohol.

Jaramillo AA, Agan VE, Makhijani VH, Pedroza S, McElligott ZA, Besheer J.

Addict Biol. 2017 Sep 27. doi: 10.1111/adb.12551. [Epub ahead of print]


Glutamate plasticity woven through the progression to alcohol use disorder: a multi-circuit perspective.

Hwa L, Besheer J, Kash T.

F1000Res. 2017 Mar 21;6:298. doi: 10.12688/f1000research.9609.1. eCollection 2017. Review.


Sex differences in alcohol self-administration and relapse-like behavior in Long-Evans rats.

Randall PA, Stewart RT, Besheer J.

Pharmacol Biochem Behav. 2017 May;156:1-9. doi: 10.1016/j.pbb.2017.03.005. Epub 2017 Mar 25.


Modulation of sensitivity to alcohol by cortical and thalamic brain regions.

Jaramillo AA, Randall PA, Frisbee S, Besheer J.

Eur J Neurosci. 2016 Oct;44(8):2569-2580. doi: 10.1111/ejn.13374. Epub 2016 Sep 8.


The nicotine + alcohol interoceptive drug state: contribution of the components and effects of varenicline in rats.

Randall PA, Cannady R, Besheer J.

Psychopharmacology (Berl). 2016 Aug;233(15-16):3061-74. doi: 10.1007/s00213-016-4354-2. Epub 2016 Jun 22.


Potentiation of amygdala AMPA receptor activity selectively promotes escalated alcohol self-administration in a CaMKII-dependent manner.

Cannady R, Fisher KR, Graham C, Crayle J, Besheer J, Hodge CW.

Addict Biol. 2017 May;22(3):652-664. doi: 10.1111/adb.12357. Epub 2016 Jan 6.


Gabapentin potentiates sensitivity to the interoceptive effects of alcohol and increases alcohol self-administration in rats.

Besheer J, Frisbee S, Randall PA, Jaramillo AA, Masciello M.

Neuropharmacology. 2016 Feb;101:216-24. doi: 10.1016/j.neuropharm.2015.09.027. Epub 2015 Sep 28.


Activation of mGluR2/3 following stress hormone exposure restores sensitivity to alcohol in rats.

Jaramillo AA, Randall PA, Frisbee S, Fisher KR, Besheer J.

Alcohol. 2015 Sep;49(6):525-32. doi: 10.1016/j.alcohol.2015.03.008. Epub 2015 Jun 19.


The role of varenicline on alcohol-primed self-administration and seeking behavior in rats.

Randall PA, Jaramillo AA, Frisbee S, Besheer J.

Psychopharmacology (Berl). 2015 Jul;232(14):2443-54. doi: 10.1007/s00213-015-3878-1. Epub 2015 Feb 7.


Interoception and learning: import to understanding and treating diseases and psychopathologies.

Bevins RA, Besheer J.

ACS Chem Neurosci. 2014 Aug 20;5(8):624-31. doi: 10.1021/cn5001028. Epub 2014 Jul 22. Review.


Overexpression of the steroidogenic enzyme cytochrome P450 side chain cleavage in the ventral tegmental area increases 3α,5α-THP and reduces long-term operant ethanol self-administration.

Cook JB, Werner DF, Maldonado-Devincci AM, Leonard MN, Fisher KR, O'Buckley TK, Porcu P, McCown TJ, Besheer J, Hodge CW, Morrow AL.

J Neurosci. 2014 Apr 23;34(17):5824-34. doi: 10.1523/JNEUROSCI.4733-13.2014.


Stress hormone exposure reduces mGluR5 expression in the nucleus accumbens: functional implications for interoceptive sensitivity to alcohol.

Besheer J, Fisher KR, Jaramillo AA, Frisbee S, Cannady R.

Neuropsychopharmacology. 2014 Sep;39(10):2376-86. doi: 10.1038/npp.2014.85. Epub 2014 Apr 9.


Authors' response to Dr. Joseph Troisi's commentary on "Assessment of the interoceptive effects of alcohol in rats using short-term training procedures".

Besheer J, Fisher KR, Durant B.

Alcohol. 2013 Sep;47(6):437-8. doi: 10.1016/j.alcohol.2013.06.001. Epub 2013 Jul 18. No abstract available.


Transient increase in alcohol self-administration following a period of chronic exposure to corticosterone.

Besheer J, Fisher KR, Lindsay TG, Cannady R.

Neuropharmacology. 2013 Sep;72:139-47. doi: 10.1016/j.neuropharm.2013.04.036. Epub 2013 May 3.


Enhanced AMPA receptor activity increases operant alcohol self-administration and cue-induced reinstatement.

Cannady R, Fisher KR, Durant B, Besheer J, Hodge CW.

Addict Biol. 2013 Jan;18(1):54-65. doi: 10.1111/adb.12000. Epub 2012 Nov 6.


Assessment of the interoceptive effects of alcohol in rats using short-term training procedures.

Besheer J, Fisher KR, Durant B.

Alcohol. 2012 Dec;46(8):747-55. doi: 10.1016/j.alcohol.2012.08.003. Epub 2012 Sep 1.

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