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Items: 1 to 20 of 176

1.

The Absence of the ACE N-Domain Decreases Renal Inflammation and Facilitates Sodium Excretion during Diabetic Kidney Disease.

Eriguchi M, Bernstein EA, Veiras LC, Khan Z, Cao DY, Fuchs S, McDonough AA, Toblli JE, Gonzalez-Villalobos RA, Bernstein KE, Giani JF.

J Am Soc Nephrol. 2018 Oct;29(10):2546-2561. doi: 10.1681/ASN.2018030323. Epub 2018 Sep 5.

PMID:
30185469
2.

Angiotensin-converting enzyme inhibitor works as a scar formation inhibitor by down-regulating Smad and TGF-β-activated kinase 1 (TAK1) pathways in mice.

Tan WQ, Fang QQ, Shen XZ, Giani JF, Zhao TV, Shi P, Zhang LY, Khan Z, Li Y, Li L, Xu JH, Bernstein EA, Bernstein KE.

Br J Pharmacol. 2018 Nov;175(22):4239-4252. doi: 10.1111/bph.14489. Epub 2018 Oct 8.

PMID:
30153328
3.

Angiotensin-converting enzyme in innate and adaptive immunity.

Bernstein KE, Khan Z, Giani JF, Cao DY, Bernstein EA, Shen XZ.

Nat Rev Nephrol. 2018 May;14(5):325-336. doi: 10.1038/nrneph.2018.15. Epub 2018 Mar 26. Review.

4.

Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis.

O'Reilly PJ, Ding Q, Akthar S, Cai G, Genschmer KR, Patel DF, Jackson PL, Viera L, Roda M, Locy ML, Bernstein EA, Lloyd CM, Bernstein KE, Snelgrove RJ, Blalock JE.

JCI Insight. 2017 Nov 16;2(22). pii: 91923. doi: 10.1172/jci.insight.91923. [Epub ahead of print]

5.

Renal tubular ACE-mediated tubular injury is the major contributor to microalbuminuria in early diabetic nephropathy.

Eriguchi M, Lin M, Yamashita M, Zhao TV, Khan Z, Bernstein EA, Gurley SB, Gonzalez-Villalobos RA, Bernstein KE, Giani JF.

Am J Physiol Renal Physiol. 2018 Apr 1;314(4):F531-F542. doi: 10.1152/ajprenal.00523.2017. Epub 2017 Nov 29.

PMID:
29187372
6.

Brain Transforming Growth Factor-β Resists Hypertension Via Regulating Microglial Activation.

Li Y, Shen XZ, Li L, Zhao TV, Bernstein KE, Johnson AK, Lyden P, Fang J, Shi P.

Stroke. 2017 Sep;48(9):2557-2564. doi: 10.1161/STROKEAHA.117.017370. Epub 2017 Jul 11.

7.

Angiotensin-converting enzyme enhances the oxidative response and bactericidal activity of neutrophils.

Khan Z, Shen XZ, Bernstein EA, Giani JF, Eriguchi M, Zhao TV, Gonzalez-Villalobos RA, Fuchs S, Liu GY, Bernstein KE.

Blood. 2017 Jul 20;130(3):328-339. doi: 10.1182/blood-2016-11-752006. Epub 2017 May 17.

8.

Angiotensin-converting enzyme affects the presentation of MHC class II antigens.

Zhao T, Bernstein KE, Fang J, Shen XZ.

Lab Invest. 2017 Jul;97(7):764-771. doi: 10.1038/labinvest.2017.32. Epub 2017 Apr 10.

9.

Renal tubular angiotensin converting enzyme is responsible for nitro-L-arginine methyl ester (L-NAME)-induced salt sensitivity.

Giani JF, Eriguchi M, Bernstein EA, Katsumata M, Shen XZ, Li L, McDonough AA, Fuchs S, Bernstein KE, Gonzalez-Villalobos RA.

Kidney Int. 2017 Apr;91(4):856-867. doi: 10.1016/j.kint.2016.10.007. Epub 2016 Dec 15.

10.

Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG.

J Clin Invest. 2016 Apr 1;126(4):1607. doi: 10.1172/JCI87425. Epub 2016 Apr 1. No abstract available.

11.

Overexpression of angiotensin-converting enzyme in myelomonocytic cells enhances the immune response.

Bernstein KE, Khan Z, Giani JF, Zhao T, Eriguchi M, Bernstein EA, Gonzalez-Villalobos RA, Shen XZ.

F1000Res. 2016 Mar 23;5. pii: F1000 Faculty Rev-393. doi: 10.12688/f1000research.7508.1. eCollection 2016. Review.

12.

CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli.

Itani HA, Xiao L, Saleh MA, Wu J, Pilkinton MA, Dale BL, Barbaro NR, Foss JD, Kirabo A, Montaniel KR, Norlander AE, Chen W, Sato R, Navar LG, Mallal SA, Madhur MS, Bernstein KE, Harrison DG.

Circ Res. 2016 Apr 15;118(8):1233-43. doi: 10.1161/CIRCRESAHA.115.308111. Epub 2016 Mar 17.

13.

Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG.

J Clin Invest. 2016 Jan;126(1):50-67. doi: 10.1172/JCI80761. Epub 2015 Nov 23. Erratum in: J Clin Invest. 2016 Apr 1;126(4):1607.

14.

Myeloid Suppressor Cells Accumulate and Regulate Blood Pressure in Hypertension.

Shah KH, Shi P, Giani JF, Janjulia T, Bernstein EA, Li Y, Zhao T, Harrison DG, Bernstein KE, Shen XZ.

Circ Res. 2015 Oct 23;117(10):858-69. doi: 10.1161/CIRCRESAHA.115.306539. Epub 2015 Aug 20.

15.

Salt Sensitivity in Response to Renal Injury Requires Renal Angiotensin-Converting Enzyme.

Giani JF, Bernstein KE, Janjulia T, Han J, Toblli JE, Shen XZ, Rodriguez-Iturbe B, McDonough AA, Gonzalez-Villalobos RA.

Hypertension. 2015 Sep;66(3):534-42. doi: 10.1161/HYPERTENSIONAHA.115.05320. Epub 2015 Jul 6.

16.

Microglia participate in neurogenic regulation of hypertension.

Shen XZ, Li Y, Li L, Shah KH, Bernstein KE, Lyden P, Shi P.

Hypertension. 2015 Aug;66(2):309-16. doi: 10.1161/HYPERTENSIONAHA.115.05333. Epub 2015 Jun 8.

17.

Angiotensin II receptor blockade or deletion of vascular endothelial ACE does not prevent vascular dysfunction and remodeling in 20-HETE-dependent hypertension.

Garcia V, Joseph G, Shkolnik B, Ding Y, Zhang FF, Gotlinger K, Falck JR, Dakarapu R, Capdevila JH, Bernstein KE, Schwartzman ML.

Am J Physiol Regul Integr Comp Physiol. 2015 Jul 1;309(1):R71-8. doi: 10.1152/ajpregu.00039.2015. Epub 2015 Apr 29.

18.

The intrarenal generation of angiotensin II is required for experimental hypertension.

Giani JF, Shah KH, Khan Z, Bernstein EA, Shen XZ, McDonough AA, Gonzalez-Villalobos RA, Bernstein KE.

Curr Opin Pharmacol. 2015 Apr;21:73-81. doi: 10.1016/j.coph.2015.01.002. Epub 2015 Jan 21. Review.

19.

DC isoketal-modified proteins activate T cells and promote hypertension.

Kirabo A, Fontana V, de Faria AP, Loperena R, Galindo CL, Wu J, Bikineyeva AT, Dikalov S, Xiao L, Chen W, Saleh MA, Trott DW, Itani HA, Vinh A, Amarnath V, Amarnath K, Guzik TJ, Bernstein KE, Shen XZ, Shyr Y, Chen SC, Mernaugh RL, Laffer CL, Elijovich F, Davies SS, Moreno H, Madhur MS, Roberts J 2nd, Harrison DG.

J Clin Invest. 2014 Oct;124(10):4642-56. doi: 10.1172/JCI74084. Epub 2014 Sep 17.

20.

Renal generation of angiotensin II and the pathogenesis of hypertension.

Giani JF, Janjulia T, Taylor B, Bernstein EA, Shah K, Shen XZ, McDonough AA, Bernstein KE, Gonzalez-Villalobos RA.

Curr Hypertens Rep. 2014 Sep;16(9):477. doi: 10.1007/s11906-014-0477-1. Review.

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