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Items: 1 to 20 of 53


Mitochondrial thiol modification by a targeted electrophile inhibits metabolism in breast adenocarcinoma cells by inhibiting enzyme activity and protein levels.

Smith MR, Vayalil PK, Zhou F, Benavides GA, Beggs RR, Golzarian H, Nijampatnam B, Oliver PG, Smith RA, Murphy MP, Velu SE, Landar A.

Redox Biol. 2016 Aug;8:136-48. doi: 10.1016/j.redox.2016.01.002. Epub 2016 Jan 8.


Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammation.

Jurkuvenaite A, Benavides GA, Komarova S, Doran SF, Johnson M, Aggarwal S, Zhang J, Darley-Usmar VM, Matalon S.

Free Radic Biol Med. 2015 Aug;85:83-94. doi: 10.1016/j.freeradbiomed.2015.03.039. Epub 2015 Apr 13.


Metabolic plasticity in resting and thrombin activated platelets.

Ravi S, Chacko B, Sawada H, Kramer PA, Johnson MS, Benavides GA, O'Donnell V, Marques MB, Darley-Usmar VM.

PLoS One. 2015 Apr 13;10(4):e0123597. doi: 10.1371/journal.pone.0123597. eCollection 2015.


Cardiomyocyte mitochondrial oxidative stress and cytoskeletal breakdown in the heart with a primary volume overload.

Yancey DM, Guichard JL, Ahmed MI, Zhou L, Murphy MP, Johnson MS, Benavides GA, Collawn J, Darley-Usmar V, Dell'Italia LJ.

Am J Physiol Heart Circ Physiol. 2015 Mar 15;308(6):H651-63. doi: 10.1152/ajpheart.00638.2014. Epub 2015 Jan 16.


Enhanced cardiac Akt/protein kinase B signaling contributes to pathological cardiac hypertrophy in part by impairing mitochondrial function via transcriptional repression of mitochondrion-targeted nuclear genes.

Wende AR, O'Neill BT, Bugger H, Riehle C, Tuinei J, Buchanan J, Tsushima K, Wang L, Caro P, Guo A, Sloan C, Kim BJ, Wang X, Pereira RO, McCrory MA, Nye BG, Benavides GA, Darley-Usmar VM, Shioi T, Weimer BC, Abel ED.

Mol Cell Biol. 2015 Mar;35(5):831-46. doi: 10.1128/MCB.01109-14. Epub 2014 Dec 22.


The Bioenergetic Health Index: a new concept in mitochondrial translational research.

Chacko BK, Kramer PA, Ravi S, Benavides GA, Mitchell T, Dranka BP, Ferrick D, Singal AK, Ballinger SW, Bailey SM, Hardy RW, Zhang J, Zhi D, Darley-Usmar VM.

Clin Sci (Lond). 2014 Sep;127(6):367-73. doi: 10.1042/CS20140101. Review.


The role of GABARAPL1/GEC1 in autophagic flux and mitochondrial quality control in MDA-MB-436 breast cancer cells.

Boyer-Guittaut M, Poillet L, Liang Q, Bôle-Richard E, Ouyang X, Benavides GA, Chakrama FZ, Fraichard A, Darley-Usmar VM, Despouy G, Jouvenot M, Delage-Mourroux R, Zhang J.

Autophagy. 2014 Jun;10(6):986-1003. doi: 10.4161/auto.28390.


Inhibition of autophagy and glycolysis by nitric oxide during hypoxia-reoxygenation impairs cellular bioenergetics and promotes cell death in primary neurons.

Benavides GA, Liang Q, Dodson M, Darley-Usmar V, Zhang J.

Free Radic Biol Med. 2013 Dec;65:1215-28. doi: 10.1016/j.freeradbiomed.2013.09.006. Epub 2013 Sep 19.


Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fibroblasts.

Liang Q, Benavides GA, Vassilopoulos A, Gius D, Darley-Usmar V, Zhang J.

Biochem J. 2013 Sep 1;454(2):249-57. doi: 10.1042/BJ20130414.


Mitochondria-targeted heme oxygenase-1 decreases oxidative stress in renal epithelial cells.

Bolisetty S, Traylor A, Zarjou A, Johnson MS, Benavides GA, Ricart K, Boddu R, Moore RD, Landar A, Barnes S, Darley-Usmar V, Agarwal A.

Am J Physiol Renal Physiol. 2013 Aug 1;305(3):F255-64. doi: 10.1152/ajprenal.00160.2013. Epub 2013 May 29.


Mitochondrially targeted compounds and their impact on cellular bioenergetics.

Reily C, Mitchell T, Chacko BK, Benavides G, Murphy MP, Darley-Usmar V.

Redox Biol. 2013;1(1):86-93.


Integration of cellular bioenergetics with mitochondrial quality control and autophagy.

Hill BG, Benavides GA, Lancaster JR Jr, Ballinger S, Dell'Italia L, Jianhua Z, Darley-Usmar VM.

Biol Chem. 2012 Dec;393(12):1485-1512. Review.


Rapid diagnosis of Mycobacterium tuberculosis infection in children using interferon-gamma release assays (IGRAs).

Riazi S, Zeligs B, Yeager H, Peters SM, Benavides GA, Di Mita O, Bellanti JA.

Allergy Asthma Proc. 2012 May-Jun;33(3):217-26. doi: 10.2500/aap.2012.33.3574.


Discharge-driven electric oxygen-iodine laser superlinear enhancement via increasing g0L.

Benavides GF, Zimmerman JW, Woodard BS, Day MT, King DM, Carroll DL, Palla AD, Verdeyen JT, Solomon WC.

Opt Lett. 2012 May 1;37(9):1409-11. doi: 10.1364/OL.37.001409.


Hemin causes mitochondrial dysfunction in endothelial cells through promoting lipid peroxidation: the protective role of autophagy.

Higdon AN, Benavides GA, Chacko BK, Ouyang X, Johnson MS, Landar A, Zhang J, Darley-Usmar VM.

Am J Physiol Heart Circ Physiol. 2012 Apr 1;302(7):H1394-409. doi: 10.1152/ajpheart.00584.2011. Epub 2012 Jan 13.


Phase 1 study of a recombinant mutant protective antigen of Bacillus anthracis.

Bellanti JA, Lin FY, Chu C, Shiloach J, Leppla SH, Benavides GA, Karpas A, Moayeri M, Guo C, Robbins JB, Schneerson R.

Clin Vaccine Immunol. 2012 Feb;19(2):140-5. doi: 10.1128/CVI.05556-11. Epub 2011 Dec 21.


Nitric oxide and hypoxia exacerbate alcohol-induced mitochondrial dysfunction in hepatocytes.

Zelickson BR, Benavides GA, Johnson MS, Chacko BK, Venkatraman A, Landar A, Betancourt AM, Bailey SM, Darley-Usmar VM.

Biochim Biophys Acta. 2011 Dec;1807(12):1573-82. doi: 10.1016/j.bbabio.2011.09.011. Epub 2011 Sep 24.


Assessing bioenergetic function in response to oxidative stress by metabolic profiling.

Dranka BP, Benavides GA, Diers AR, Giordano S, Zelickson BR, Reily C, Zou L, Chatham JC, Hill BG, Zhang J, Landar A, Darley-Usmar VM.

Free Radic Biol Med. 2011 Nov 1;51(9):1621-35. doi: 10.1016/j.freeradbiomed.2011.08.005. Epub 2011 Aug 16.


Mitochondria-targeted ubiquinone (MitoQ) decreases ethanol-dependent micro and macro hepatosteatosis.

Chacko BK, Srivastava A, Johnson MS, Benavides GA, Chang MJ, Ye Y, Jhala N, Murphy MP, Kalyanaraman B, Darley-Usmar VM.

Hepatology. 2011 Jul;54(1):153-63. doi: 10.1002/hep.24377.


The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial.

CRASH-2 collaborators, Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T.

Lancet. 2011 Mar 26;377(9771):1096-101, 1101.e1-2. doi: 10.1016/S0140-6736(11)60278-X.

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