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Items: 1 to 20 of 44


Photoreceptor Outer Segment Isolation from a Single Canine Retina for RPE Phagocytosis Assay.

Sudharsan R, Elliott MH, Dolgova N, Aguirre GD, Beltran WA.

Adv Exp Med Biol. 2018;1074:593-601. doi: 10.1007/978-3-319-75402-4_72.


BEST1 gene therapy corrects a diffuse retina-wide microdetachment modulated by light exposure.

Guziewicz KE, Cideciyan AV, Beltran WA, Komáromy AM, Dufour VL, Swider M, Iwabe S, Sumaroka A, Kendrick BT, Ruthel G, Chiodo VA, Héon E, Hauswirth WW, Jacobson SG, Aguirre GD.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2839-E2848. doi: 10.1073/pnas.1720662115. Epub 2018 Mar 5.


Involvement of Innate Immune System in Late Stages of Inherited Photoreceptor Degeneration.

Sudharsan R, Beiting DP, Aguirre GD, Beltran WA.

Sci Rep. 2017 Dec 20;7(1):17897. doi: 10.1038/s41598-017-18236-7.


Optimization of Retinal Gene Therapy for X-Linked Retinitis Pigmentosa Due to RPGR Mutations.

Beltran WA, Cideciyan AV, Boye SE, Ye GJ, Iwabe S, Dufour VL, Marinho LF, Swider M, Kosyk MS, Sha J, Boye SL, Peterson JJ, Witherspoon CD, Alexander JJ, Ying GS, Shearman MS, Chulay JD, Hauswirth WW, Gamlin PD, Jacobson SG, Aguirre GD.

Mol Ther. 2017 Aug 2;25(8):1866-1880. doi: 10.1016/j.ymthe.2017.05.004. Epub 2017 May 27.


Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant Retinitis Pigmentosa.

Sudharsan R, Simone KM, Anderson NP, Aguirre GD, Beltran WA.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):270-281. doi: 10.1167/iovs.16-20749.


Overlap of abnormal photoreceptor development and progressive degeneration in Leber congenital amaurosis caused by NPHP5 mutation.

Downs LM, Scott EM, Cideciyan AV, Iwabe S, Dufour V, Gardiner KL, Genini S, Marinho LF, Sumaroka A, Kosyk MS, Swider M, Aguirre GK, Jacobson SG, Beltran WA, Aguirre GD.

Hum Mol Genet. 2016 Oct 1;25(19):4211-4226. doi: 10.1093/hmg/ddw254. Epub 2016 Aug 9.


Assessment of visual function and retinal structure following acute light exposure in the light sensitive T4R rhodopsin mutant dog.

Iwabe S, Ying GS, Aguirre GD, Beltran WA.

Exp Eye Res. 2016 May;146:341-53. doi: 10.1016/j.exer.2016.04.006. Epub 2016 Apr 13.


Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease.

Beltran WA, Cideciyan AV, Iwabe S, Swider M, Kosyk MS, McDaid K, Martynyuk I, Ying GS, Shaffer J, Deng WT, Boye SL, Lewin AS, Hauswirth WW, Jacobson SG, Aguirre GD.

Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):E5844-53. doi: 10.1073/pnas.1509914112. Epub 2015 Oct 12.


Exclusion of the unfolded protein response in light-induced retinal degeneration in the canine T4R RHO model of autosomal dominant retinitis pigmentosa.

Marsili S, Genini S, Sudharsan R, Gingrich J, Aguirre GD, Beltran WA.

PLoS One. 2015 Feb 19;10(2):e0115723. doi: 10.1371/journal.pone.0115723. eCollection 2015.


Temporal dynamics of arthropods on six tree species in dry woodlands on the Caribbean Island of Puerto Rico.

Beltrán W, Wunderle JM Jr.

J Insect Sci. 2014 Jan 1;14. pii: 199. doi: 10.1093/jisesa/ieu061. Print 2014.


Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells.

Gaub BM, Berry MH, Holt AE, Reiner A, Kienzler MA, Dolgova N, Nikonov S, Aguirre GD, Beltran WA, Flannery JG, Isacoff EY.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):E5574-83. doi: 10.1073/pnas.1414162111. Epub 2014 Dec 8.


Gene augmentation for X-linked retinitis pigmentosa caused by mutations in RPGR.

Beltran WA, Cideciyan AV, Lewin AS, Hauswirth WW, Jacobson SG, Aguirre GD.

Cold Spring Harb Perspect Med. 2014 Oct 9;5(2):a017392. doi: 10.1101/cshperspect.a017392. Review.


Isolation and ex vivo characterization of the immunophenotype and function of microglia/macrophage populations in normal dog retina.

Genini S, Beltran WA, Stein VM, Aguirre GD.

Adv Exp Med Biol. 2014;801:339-45. doi: 10.1007/978-1-4614-3209-8_43.


Canine retina has a primate fovea-like bouquet of cone photoreceptors which is affected by inherited macular degenerations.

Beltran WA, Cideciyan AV, Guziewicz KE, Iwabe S, Swider M, Scott EM, Savina SV, Ruthel G, Stefano F, Zhang L, Zorger R, Sumaroka A, Jacobson SG, Aguirre GD.

PLoS One. 2014 Mar 5;9(3):e90390. doi: 10.1371/journal.pone.0090390. eCollection 2014.


Altered miRNA expression in canine retinas during normal development and in models of retinal degeneration.

Genini S, Guziewicz KE, Beltran WA, Aguirre GD.

BMC Genomics. 2014 Mar 1;15:172. doi: 10.1186/1471-2164-15-172.


Up-regulation of tumor necrosis factor superfamily genes in early phases of photoreceptor degeneration.

Genini S, Beltran WA, Aguirre GD.

PLoS One. 2013 Dec 19;8(12):e85408. doi: 10.1371/journal.pone.0085408. eCollection 2013.


Recombinant AAV-mediated BEST1 transfer to the retinal pigment epithelium: analysis of serotype-dependent retinal effects.

Guziewicz KE, Zangerl B, Komáromy AM, Iwabe S, Chiodo VA, Boye SL, Hauswirth WW, Beltran WA, Aguirre GD.

PLoS One. 2013 Oct 15;8(10):e75666. doi: 10.1371/journal.pone.0075666. eCollection 2013.


Early histopathologic changes in the retina and optic nerve in canine primary angle-closure glaucoma.

Scott EM, Boursiquot N, Beltran WA, Dubielzig RR.

Vet Ophthalmol. 2013 Jul;16 Suppl 1:79-86. doi: 10.1111/vop.12046.


Reply to Townes-Anderson: RPE65 gene therapy does not alter the natural history of retinal degeneration.

Cideciyan AV, Jacobson SG, Beltran WA, Hauswirth WW, Aguirre GD.

Proc Natl Acad Sci U S A. 2013 May 7;110(19):E1706. No abstract available.


Transient photoreceptor deconstruction by CNTF enhances rAAV-mediated cone functional rescue in late stage CNGB3-achromatopsia.

Komáromy AM, Rowlan JS, Corr AT, Reinstein SL, Boye SL, Cooper AE, Gonzalez A, Levy B, Wen R, Hauswirth WW, Beltran WA, Aguirre GD.

Mol Ther. 2013 Jun;21(6):1131-41. doi: 10.1038/mt.2013.50. Epub 2013 Apr 9.

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