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Human Cancer Cells Signal Their Competitive Fitness Through MYC Activity.

Di Giacomo S, Sollazzo M, de Biase D, Ragazzi M, Bellosta P, Pession A, Grifoni D.

Sci Rep. 2017 Oct 3;7(1):12568. doi: 10.1038/s41598-017-13002-1.


The Stearoyl-CoA Desaturase-1 (Desat1) in Drosophila cooperated with Myc to Induce Autophagy and Growth, a Potential New Link to Tumor Survival.

Paiardi C, Mirzoyan Z, Zola S, Parisi F, Vingiani A, Pasini ME, Bellosta P.

Genes (Basel). 2017 Apr 28;8(5). pii: E131. doi: 10.3390/genes8050131.


Drosophila Myc: A master regulator of cellular performance.

Grifoni D, Bellosta P.

Biochim Biophys Acta. 2015 May;1849(5):570-81. doi: 10.1016/j.bbagrm.2014.06.021. Epub 2014 Jul 8. Review.


Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viability.

de la Cova C, Senoo-Matsuda N, Ziosi M, Wu DC, Bellosta P, Quinzii CM, Johnston LA.

Cell Metab. 2014 Mar 4;19(3):470-83. doi: 10.1016/j.cmet.2014.01.012. Epub 2014 Feb 20.


dMyc expression in the fat body affects DILP2 release and increases the expression of the fat desaturase Desat1 resulting in organismal growth.

Parisi F, Riccardo S, Zola S, Lora C, Grifoni D, Brown LM, Bellosta P.

Dev Biol. 2013 Jul 1;379(1):64-75. doi: 10.1016/j.ydbio.2013.04.008. Epub 2013 Apr 19.


Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo.

Parisi F, Riccardo S, Daniel M, Saqcena M, Kundu N, Pession A, Grifoni D, Stocker H, Tabak E, Bellosta P.

BMC Biol. 2011 Sep 27;9:65. doi: 10.1186/1741-7007-9-65.


Myc Function in Drosophila.

Bellosta P, Gallant P.

Genes Cancer. 2010 Jun 1;1(6):542-546.


dMyc functions downstream of Yorkie to promote the supercompetitive behavior of hippo pathway mutant cells.

Ziosi M, Baena-López LA, Grifoni D, Froldi F, Pession A, Garoia F, Trotta V, Bellosta P, Cavicchi S, Pession A.

PLoS Genet. 2010 Sep 23;6(9):e1001140. doi: 10.1371/journal.pgen.1001140.


The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy.

Froldi F, Ziosi M, Garoia F, Pession A, Grzeschik NA, Bellosta P, Strand D, Richardson HE, Pession A, Grifoni D.

BMC Biol. 2010 Apr 7;8:33. doi: 10.1186/1741-7007-8-33.


Identification of domains responsible for ubiquitin-dependent degradation of dMyc by glycogen synthase kinase 3beta and casein kinase 1 kinases.

Galletti M, Riccardo S, Parisi F, Lora C, Saqcena MK, Rivas L, Wong B, Serra A, Serras F, Grifoni D, Pelicci P, Jiang J, Bellosta P.

Mol Cell Biol. 2009 Jun;29(12):3424-34. doi: 10.1128/MCB.01535-08. Epub 2009 Apr 13.


Osteoblast proliferation or differentiation is regulated by relative strengths of opposing signaling pathways.

Raucci A, Bellosta P, Grassi R, Basilico C, Mansukhani A.

J Cell Physiol. 2008 May;215(2):442-51.


aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia.

Grifoni D, Garoia F, Bellosta P, Parisi F, De Biase D, Collina G, Strand D, Cavicchi S, Pession A.

Oncogene. 2007 Aug 30;26(40):5960-5. Epub 2007 Mar 19.


A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control.

Budagian V, Bulanova E, Orinska Z, Thon L, Mamat U, Bellosta P, Basilico C, Adam D, Paus R, Bulfone-Paus S.

EMBO J. 2005 Dec 21;24(24):4260-70. Epub 2005 Nov 24. Retraction in: EMBO J. 2011 Feb 2;30(3):627.


Myc interacts genetically with Tip48/Reptin and Tip49/Pontin to control growth and proliferation during Drosophila development.

Bellosta P, Hulf T, Balla Diop S, Usseglio F, Pradel J, Aragnol D, Gallant P.

Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11799-804. Epub 2005 Aug 8.


Whole-genome analysis reveals a strong positional bias of conserved dMyc-dependent E-boxes.

Hulf T, Bellosta P, Furrer M, Steiger D, Svensson D, Barbour A, Gallant P.

Mol Cell Biol. 2005 May;25(9):3401-10.


Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor.

Sainaghi PP, Castello L, Bergamasco L, Galletti M, Bellosta P, Avanzi GC.

J Cell Physiol. 2005 Jul;204(1):36-44.


Drosophila myc regulates organ size by inducing cell competition.

de la Cova C, Abril M, Bellosta P, Gallant P, Johnston LA.

Cell. 2004 Apr 2;117(1):107-16.


p21(WAF1/CIP1) acts as a brake in osteoblast differentiation.

Bellosta P, Masramon L, Mansukhani A, Basilico C.

J Bone Miner Res. 2003 May;18(5):818-26.


Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis.

Bellosta P, Iwahori A, Plotnikov AN, Eliseenkova AV, Basilico C, Mohammadi M.

Mol Cell Biol. 2001 Sep;21(17):5946-57.

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