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Items: 1 to 20 of 75


Comparison of the efficacy and safety of FP-1201-lyo (intravenously administered recombinant human interferon beta-1a) and placebo in the treatment of patients with moderate or severe acute respiratory distress syndrome: study protocol for a randomized controlled trial.

Bellingan G, Brealey D, Mancebo J, Mercat A, Patroniti N, Pettilä V, Quintel M, Vincent JL, Maksimow M, Jalkanen M, Piippo I, Ranieri VM.

Trials. 2017 Nov 13;18(1):536. doi: 10.1186/s13063-017-2234-7.


Effect of Early Vasopressin vs Norepinephrine on Kidney Failure in Patients With Septic Shock: The VANISH Randomized Clinical Trial.

Gordon AC, Mason AJ, Thirunavukkarasu N, Perkins GD, Cecconi M, Cepkova M, Pogson DG, Aya HD, Anjum A, Frazier GJ, Santhakumaran S, Ashby D, Brett SJ; VANISH Investigators.

JAMA. 2016 Aug 2;316(5):509-18. doi: 10.1001/jama.2016.10485.


A multicentre, randomised controlled trial comparing the clinical effectiveness and cost-effectiveness of early nutritional support via the parenteral versus the enteral route in critically ill patients (CALORIES).

Harvey SE, Parrott F, Harrison DA, Sadique MZ, Grieve RD, Canter RR, McLennan BK, Tan JC, Bear DE, Segaran E, Beale R, Bellingan G, Leonard R, Mythen MG, Rowan KM.

Health Technol Assess. 2016 Apr;20(28):1-144. doi: 10.3310/hta20280.


Association between trends in clinical variables and outcome in intensive care patients with faecal peritonitis: analysis of the GenOSept cohort.

Tridente A, Clarke GM, Walden A, Gordon AC, Hutton P, Chiche JD, Holloway PA, Mills GH, Bion J, Stüber F, Garrard C, Hinds C; GenOSept Investigators.

Crit Care. 2015 May 5;19:210. doi: 10.1186/s13054-015-0931-8.


A randomised controlled trial and cost-effectiveness analysis of high-frequency oscillatory ventilation against conventional artificial ventilation for adults with acute respiratory distress syndrome. The OSCAR (OSCillation in ARDS) study.

Lall R, Hamilton P, Young D, Hulme C, Hall P, Shah S, MacKenzie I, Tunnicliffe W, Rowan K, Cuthbertson B, McCabe C, Lamb S; OSCAR collaborators.

Health Technol Assess. 2015 Mar;19(23):1-177, vii. doi: 10.3310/hta19230.


Sepsis biomarkers.

Prucha M, Bellingan G, Zazula R.

Clin Chim Acta. 2015 Feb 2;440:97-103. doi: 10.1016/j.cca.2014.11.012. Epub 2014 Nov 18. Review.


Trial of the route of early nutritional support in critically ill adults.

Harvey SE, Parrott F, Harrison DA, Bear DE, Segaran E, Beale R, Bellingan G, Leonard R, Mythen MG, Rowan KM; CALORIES Trial Investigators.

N Engl J Med. 2014 Oct 30;371(18):1673-84. doi: 10.1056/NEJMoa1409860. Epub 2014 Oct 1.


Simvastatin in the acute respiratory distress syndrome.

McAuley DF, Laffey JG, O'Kane CM, Perkins GD, Mullan B, Trinder TJ, Johnston P, Hopkins PA, Johnston AJ, McDowell C, McNally C; HARP-2 Investigators; Irish Critical Care Trials Group.

N Engl J Med. 2014 Oct 30;371(18):1695-703. doi: 10.1056/NEJMoa1403285. Epub 2014 Sep 30. Erratum in: N Engl J Med. 2016 Nov 17;375(20):2010.


Management of a mixed overdose of calcium channel blockers, β-blockers and statins.

Thakrar R, Shulman R, Bellingan G, Singer M.

BMJ Case Rep. 2014 Jun 6;2014. pii: bcr2014204732. doi: 10.1136/bcr-2014-204732.


Effect of a perioperative, cardiac output-guided hemodynamic therapy algorithm on outcomes following major gastrointestinal surgery: a randomized clinical trial and systematic review.

Pearse RM, Harrison DA, MacDonald N, Gillies MA, Blunt M, Ackland G, Grocott MP, Ahern A, Griggs K, Scott R, Hinds C, Rowan K; OPTIMISE Study Group.

JAMA. 2014 Jun 4;311(21):2181-90. doi: 10.1001/jama.2014.5305. Erratum in: JAMA. 2014 Oct 8;312(14):1473.


Observational study of current use of selective decontamination of the digestive tract in UK critical care units.

Canter RR, Harvey SE, Harrison DA, Campbell MK, Rowan KM, Cuthbertson BH; Selective Decontamination of the Digestive tract in critically ill patients treated in Intensive Care Unit (SuDDICU) Investigators.

Br J Anaesth. 2014 Oct;113(4):610-7. doi: 10.1093/bja/aeu108. Epub 2014 May 14.


Selective decontamination of the digestive tract in critically ill patients treated in intensive care units: a mixed-methods feasibility study (the SuDDICU study).

Francis JJ, Duncan EM, Prior ME, Maclennan GS, Dombrowski S, Bellingan GU, Campbell MK, Eccles MP, Rose L, Rowan KM, Shulman R, Peter R Wilson A, Cuthbertson BH.

Health Technol Assess. 2014 Apr;18(25):1-170. doi: 10.3310/hta18250.


The views of health care professionals about selective decontamination of the digestive tract: an international, theoretically informed interview study.

Duncan EM, Cuthbertson BH, Prior ME, Marshall AP, Wells EC, Todd LE, Bolsover D, Newlands RS, Webster F, Rose L, Campbell MK, Bellingan G, Seppelt IM, Francis JJ; SuDDICU International Study Group.

J Crit Care. 2014 Aug;29(4):634-40. doi: 10.1016/j.jcrc.2014.03.013. Epub 2014 Mar 21.


Use of interferon beta for acute respiratory distress syndrome: proceed with caution--authors' reply.

Bellingan G, Montgomery H, Maksimow M, Salmi M, Jalkanen S.

Lancet Respir Med. 2014 Apr;2(4):e2-3. doi: 10.1016/S2213-2600(14)70052-9. No abstract available.


The effect of intravenous interferon-beta-1a (FP-1201) on lung CD73 expression and on acute respiratory distress syndrome mortality: an open-label study.

Bellingan G, Maksimow M, Howell DC, Stotz M, Beale R, Beatty M, Walsh T, Binning A, Davidson A, Kuper M, Shah S, Cooper J, Waris M, Yegutkin GG, Jalkanen J, Salmi M, Piippo I, Jalkanen M, Montgomery H, Jalkanen S.

Lancet Respir Med. 2014 Feb;2(2):98-107. doi: 10.1016/S2213-2600(13)70259-5. Epub 2013 Dec 23.


Presence of hypogammaglobulinemia - a risk factor of mortality in patients with severe sepsis, septic shock, and SIRS.

Průcha M, Zazula R, Herold I, Dostál M, Hyánek T, Bellingan G.

Prague Med Rep. 2013;114(4):246-57.


Presence of hypogammaglobulinemia in patients with severe sepsis, septic shock, and SIRS is associated with increased mortality.

Prucha M, Zazula R, Herold I, Dostal M, Hyanek T, Bellingan G.

J Infect. 2014 Mar;68(3):297-9. doi: 10.1016/j.jinf.2013.11.003. Epub 2013 Nov 15. No abstract available.


Clinical stakeholders' opinions on the use of selective decontamination of the digestive tract in critically ill patients in intensive care units: an international Delphi study.

Cuthbertson BH, Campbell MK, MacLennan G, Duncan EM, Marshall AP, Wells EC, Prior ME, Todd L, Rose L, Seppelt IM, Bellingan G, Francis JJ.

Crit Care. 2013 Nov 8;17(6):R266. doi: 10.1186/cc13096.


Comparison of four methods for assessing the importance of attitudinal beliefs: an international Delphi study in intensive care settings.

Francis JJ, Duncan EM, Prior ME, Maclennan G, Marshall AP, Wells EC, Todd L, Rose L, Campbell MK, Webster F, Eccles MP, Bellingan G, Seppelt IM, Grimshaw JM, Cuthbertson BH; SuDDICU study groups.

Br J Health Psychol. 2014 May;19(2):274-91. doi: 10.1111/bjhp.12066. Epub 2013 Sep 23.


Effect of early vs late tracheostomy placement on survival in patients receiving mechanical ventilation: the TracMan randomized trial.

Young D, Harrison DA, Cuthbertson BH, Rowan K; TracMan Collaborators.

JAMA. 2013 May 22;309(20):2121-9. doi: 10.1001/jama.2013.5154.


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