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Items: 1 to 20 of 268

1.

Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance.

Rode B, Shi J, Endesh N, Drinkhill MJ, Webster PJ, Lotteau SJ, Bailey MA, Yuldasheva NY, Ludlow MJ, Cubbon RM, Li J, Futers TS, Morley L, Gaunt HJ, Marszalek K, Viswambharan H, Cuthbertson K, Baxter PD, Foster R, Sukumar P, Weightman A, Calaghan SC, Wheatcroft SB, Kearney MT, Beech DJ.

Nat Commun. 2017 Aug 24;8(1):350. doi: 10.1038/s41467-017-00429-3.

2.

Endothelial SHIP2 Suppresses Nox2 NADPH Oxidase-Dependent Vascular Oxidative Stress, Endothelial Dysfunction and Systemic Insulin Resistance.

Watt NT, Gage MC, Patel PA, Viswambharan H, Sukumar P, Galloway S, Yuldasheva NY, Imrie H, Walker AM, Griffin KJ, Makava N, Skromna A, Bridge K, Beech DJ, Schurmans S, Wheatcroft SB, Kearney MT, Cubbon RM.

Diabetes. 2017 Aug 22. pii: db170062. doi: 10.2337/db17-0062. [Epub ahead of print]

PMID:
28830894
3.

Piezo1 Channels in Vascular Development and the Sensing of Shear Stress.

Hyman AJ, Tumova S, Beech DJ.

Curr Top Membr. 2017;79:37-57. doi: 10.1016/bs.ctm.2016.11.001. Epub 2017 Jan 10.

PMID:
28728823
4.

Pico145 - powerful new tool for TRPC1/4/5 channels.

Rubaiy HN, Ludlow MJ, Bon RS, Beech DJ.

Channels (Austin). 2017 Apr 11:1-3. doi: 10.1080/19336950.2017.1317485. [Epub ahead of print] No abstract available.

PMID:
28399685
5.

Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.

Rubaiy HN, Ludlow MJ, Henrot M, Gaunt HJ, Miteva K, Cheung SY, Tanahashi Y, Hamzah N, Musialowski KE, Blythe NM, Appleby HL, Bailey MA, McKeown L, Taylor R, Foster R, Waldmann H, Nussbaumer P, Christmann M, Bon RS, Muraki K, Beech DJ.

J Biol Chem. 2017 May 19;292(20):8158-8173. doi: 10.1074/jbc.M116.773556. Epub 2017 Mar 21.

6.

AZD1775 Induces Toxicity Through Double-Stranded DNA Breaks Independently of Chemotherapeutic Agents in p53-Mutated Colorectal Cancer Cells.

Webster PJ, Littlejohns AT, Gaunt HJ, Prasad KR, Beech DJ, Burke DA.

Cell Cycle. 2017 Mar 15:0. doi: 10.1080/15384101.2017.1301329. [Epub ahead of print]

PMID:
28296564
7.

Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases.

Webster PJ, Littlejohns AT, Gaunt HJ, Young RS, Rode B, Ritchie JE, Stead LF, Harrison S, Droop A, Martin HL, Tomlinson DC, Hyman AJ, Appleby HL, Boxall S, Bruns AF, Li J, Prasad RK, Lodge JPA, Burke DA, Beech DJ.

Oncotarget. 2017 Jun 27;8(26):42288-42299. doi: 10.18632/oncotarget.15039.

8.

Hospital-based, Multidisciplinary, youth mentoring and medical exposure program positively influences and reinforces health care career choice: "The Reach One Each One Program early Experience".

Danner OK, Lokko C, Mobley F, Dansby M, Maze M, Bradley B, Williams E, Matthews LR, Harrington E, Mack L, Clark C, Wilson K, Beech D, Heron S, Childs E.

Am J Surg. 2017 Apr;213(4):611-616. doi: 10.1016/j.amjsurg.2016.12.002. Epub 2016 Dec 14.

PMID:
28040097
9.

Leptin-Notch signaling axis is involved in pancreatic cancer progression.

Harbuzariu A, Rampoldi A, Daley-Brown DS, Candelaria P, Harmon TL, Lipsey CC, Beech DJ, Quarshie A, Ilies GO, Gonzalez-Perez RR.

Oncotarget. 2017 Jan 31;8(5):7740-7752. doi: 10.18632/oncotarget.13946.

10.

Selective Enhancement of Insulin Sensitivity in the Endothelium In Vivo Reveals a Novel Proatherosclerotic Signaling Loop.

Viswambharan H, Yuldasheva NY, Sengupta A, Imrie H, Gage MC, Haywood N, Walker AM, Skromna A, Makova N, Galloway S, Shah P, Sukumar P, Porter KE, Grant PJ, Shah AM, Santos CX, Li J, Beech DJ, Wheatcroft SB, Cubbon RM, Kearney MT.

Circ Res. 2017 Mar 3;120(5):784-798. doi: 10.1161/CIRCRESAHA.116.309678. Epub 2016 Dec 5.

PMID:
27920123
11.

(-)-Englerin A-evoked Cytotoxicity Is Mediated by Na+ Influx and Counteracted by Na+/K+-ATPase.

Ludlow MJ, Gaunt HJ, Rubaiy HN, Musialowski KE, Blythe NM, Vasudev NS, Muraki K, Beech DJ.

J Biol Chem. 2017 Jan 13;292(2):723-731. doi: 10.1074/jbc.M116.755678. Epub 2016 Nov 14.

12.

Non-selective cationic channels in chemical and physical stress.

Beech DJ.

J Physiol. 2016 Aug 1;594(15):4139. doi: 10.1113/JP270937. No abstract available.

13.

Implementing the Prospective Surveillance Model (PSM) of Rehabilitation for Breast Cancer Patients with 1-Year Postoperative Follow-up, a Prospective, Observational Study.

Lai L, Binkley J, Jones V, Kirkpatrick S, Furbish C, Stratford P, Thompson W, Sidhu A, Farley C, Okoli J, Beech D, Gabram S.

Ann Surg Oncol. 2016 Oct;23(10):3379-84. doi: 10.1245/s10434-016-5315-z. Epub 2016 Jun 22.

PMID:
27334210
14.

Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics.

Gaunt HJ, Vasudev NS, Beech DJ.

Eur Biophys J. 2016 Oct;45(7):611-620. Epub 2016 Jun 11. Review.

15.

CCR6 expression in colon cancer is associated with advanced disease and supports epithelial-to-mesenchymal transition.

Kapur N, Mir H, Clark Iii CE, Krishnamurti U, Beech DJ, Lillard JW, Singh S.

Br J Cancer. 2016 Jun 14;114(12):1343-51. doi: 10.1038/bjc.2016.113. Epub 2016 May 5.

16.

Molecular Mechanism Linking BRCA1 Dysfunction to High Grade Serous Epithelial Ovarian Cancers with Peritoneal Permeability and Ascites.

Desai A, Xu J, Aysola K, Akinbobuyi O, White M, Reddy VE, Okoli J, Clark C, Partridge EE, Childs E, Beech DJ, Rice MV, Reddy E, Rao VN.

J Gynecol Res. 2015;1(1). pii: 103. Epub 2015 Apr 24.

17.

Natural and synthetic flavonoid modulation of TRPC5 channels.

Naylor J, Minard A, Gaunt HJ, Amer MS, Wilson LA, Migliore M, Cheung SY, Rubaiy HN, Blythe NM, Musialowski KE, Ludlow MJ, Evans WD, Green BL, Yang H, You Y, Li J, Fishwick CW, Muraki K, Beech DJ, Bon RS.

Br J Pharmacol. 2016 Feb;173(3):562-74. doi: 10.1111/bph.13387. Epub 2016 Jan 13.

18.

Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor.

Li J, Bruns AF, Hou B, Rode B, Webster PJ, Bailey MA, Appleby HL, Moss NK, Ritchie JE, Yuldasheva NY, Tumova S, Quinney M, McKeown L, Taylor H, Prasad KR, Burke D, O'Regan D, Porter KE, Foster R, Kearney MT, Beech DJ.

Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1987-94. doi: 10.1161/ATVBAHA.115.305969. Epub 2015 Jul 9.

19.

Identification of Extracolonic Pathologies by Computed Tomographic Colonography in Colorectal Cancer Symptomatic Patients.

Halligan S, Wooldrage K, Dadswell E, Shah U, Kralj-Hans I, von Wagner C, Faiz O, Teare J, Edwards R, Kay C, Yao G, Lilford RJ, Morton D, Wardle J, Atkin W; SIGGAR Investigators.

Gastroenterology. 2015 Jul;149(1):89-101.e5. doi: 10.1053/j.gastro.2015.03.011. Epub 2015 Mar 18.

PMID:
25796362
20.

(-)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels.

Akbulut Y, Gaunt HJ, Muraki K, Ludlow MJ, Amer MS, Bruns A, Vasudev NS, Radtke L, Willot M, Hahn S, Seitz T, Ziegler S, Christmann M, Beech DJ, Waldmann H.

Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3787-91. doi: 10.1002/anie.201411511. Epub 2015 Feb 23.

PMID:
25707820

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