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Microbiome balance in sputum determined by PCR stratifies COPD exacerbations and shows potential for selective use of antibiotics.

Haldar K, Bafadhel M, Lau K, Berg A, Kwambana B, Kebadze T, Ramsheh MY, Barker B, Haldar P, Johnston S, Ketley JM, Brightling CE, Barer MR.

PLoS One. 2017 Aug 25;12(8):e0182833. doi: 10.1371/journal.pone.0182833. eCollection 2017.


Rapid replacement by non-vaccine pneumococcal serotypes may mitigate the impact of the pneumococcal conjugate vaccine on nasopharyngeal bacterial ecology.

Kwambana-Adams B, Hanson B, Worwui A, Agbla S, Foster-Nyarko E, Ceesay F, Ebruke C, Egere U, Zhou Y, Ndukum M, Sodergren E, Barer M, Adegbola R, Weinstock G, Antonio M.

Sci Rep. 2017 Aug 15;7(1):8127. doi: 10.1038/s41598-017-08717-0.


The role of hydrophobicity in tuberculosis evolution and pathogenicity.

Jankute M, Nataraj V, Lee OY, Wu HHT, Ridell M, Garton NJ, Barer MR, Minnikin DE, Bhatt A, Besra GS.

Sci Rep. 2017 May 2;7(1):1315. doi: 10.1038/s41598-017-01501-0.


Investigating the role of pentraxin 3 as a biomarker for bacterial infection in subjects with COPD.

Thulborn SJ, Dilpazir M, Haldar K, Mistry V, Brightling CE, Barer MR, Bafadhel M.

Int J Chron Obstruct Pulmon Dis. 2017 Apr 18;12:1199-1205. doi: 10.2147/COPD.S123528. eCollection 2017.


Association of slow recovery of Mycobacterium africanum-infected patients posttreatment with high content of Persister-Like bacilli in pretreatment sputum.

Tientcheu LD, Bell A, Secka O, Ayorinde A, Otu J, Garton NJ, Sutherland JS, Ota MO, Antonio M, Dockrell HM, Kampmann B, Barer MR.

Int J Mycobacteriol. 2016 Dec;5 Suppl 1:S99-S100. doi: 10.1016/j.ijmyco.2016.09.033. Epub 2016 Nov 11.


Examining regional variation in health care spending in British Columbia, Canada.

Lavergne MR, Barer M, Law MR, Wong ST, Peterson S, McGrail K.

Health Policy. 2016 Jul;120(7):739-48. doi: 10.1016/j.healthpol.2016.04.007. Epub 2016 Apr 20.


Lung microbiome dynamics in COPD exacerbations.

Wang Z, Bafadhel M, Haldar K, Spivak A, Mayhew D, Miller BE, Tal-Singer R, Johnston SL, Ramsheh MY, Barer MR, Brightling CE, Brown JR.

Eur Respir J. 2016 Apr;47(4):1082-92. doi: 10.1183/13993003.01406-2015. Epub 2016 Feb 25.


Phenotypically Adapted Mycobacterium tuberculosis Populations from Sputum Are Tolerant to First-Line Drugs.

Turapov O, O'Connor BD, Sarybaeva AA, Williams C, Patel H, Kadyrov AS, Sarybaev AS, Woltmann G, Barer MR, Mukamolova GV.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2476-83. doi: 10.1128/AAC.01380-15. Print 2016 Apr.


Airway bacteria measured by quantitative polymerase chain reaction and culture in patients with stable COPD: relationship with neutrophilic airway inflammation, exacerbation frequency, and lung function.

Bafadhel M, Haldar K, Barker B, Patel H, Mistry V, Barer MR, Pavord ID, Brightling CE.

Int J Chron Obstruct Pulmon Dis. 2015 Jun 9;10:1075-83. doi: 10.2147/COPD.S80091. eCollection 2015.


Pharmacodynamic Modeling of Bacillary Elimination Rates and Detection of Bacterial Lipid Bodies in Sputum to Predict and Understand Outcomes in Treatment of Pulmonary Tuberculosis.

Sloan DJ, Mwandumba HC, Garton NJ, Khoo SH, Butterworth AE, Allain TJ, Heyderman RS, Corbett EL, Barer MR, Davies GR.

Clin Infect Dis. 2015 Jul 1;61(1):1-8. doi: 10.1093/cid/civ195. Epub 2015 Mar 16.


Classifying physician practice style: a new approach using administrative data in British Columbia.

McGrail K, Lavergne R, Lewis SJ, Peterson SL, Barer M, Garrison SR.

Med Care. 2015 Mar;53(3):276-82. doi: 10.1097/MLR.0000000000000310.


Systemic and pulmonary inflammation is independent of skeletal muscle changes in patients with chronic obstructive pulmonary disease.

Barker BL, McKenna S, Mistry V, Pancholi M, Patel H, Haldar K, Barer MR, Pavord ID, Steiner MC, Brightling CE, Bafadhel M.

Int J Chron Obstruct Pulmon Dis. 2014 Sep 15;9:975-81. doi: 10.2147/COPD.S63568. eCollection 2014.


Face mask sampling for the detection of Mycobacterium tuberculosis in expelled aerosols.

Williams CM, Cheah ES, Malkin J, Patel H, Otu J, Mlaga K, Sutherland JS, Antonio M, Perera N, Woltmann G, Haldar P, Garton NJ, Barer MR.

PLoS One. 2014 Aug 14;9(8):e104921. doi: 10.1371/journal.pone.0104921. eCollection 2014.


Association between pathogens detected using quantitative polymerase chain reaction with airway inflammation in COPD at stable state and exacerbations.

Barker BL, Haldar K, Patel H, Pavord ID, Barer MR, Brightling CE, Bafadhel M.

Chest. 2015 Jan;147(1):46-55. doi: 10.1378/chest.14-0764.


The implications of the feminization of the primary care physician workforce on service supply: a systematic review.

Hedden L, Barer ML, Cardiff K, McGrail KM, Law MR, Bourgeault IL.

Hum Resour Health. 2014 Jun 4;12:32. doi: 10.1186/1478-4491-12-32. Review.


Randomised controlled trial and health economic evaluation of the impact of diagnostic testing for influenza, respiratory syncytial virus and Streptococcus pneumoniae infection on the management of acute admissions in the elderly and high-risk 18- to 64-year-olds.

Nicholson KG, Abrams KR, Batham S, Medina MJ, Warren FC, Barer M, Bermingham A, Clark TW, Latimer N, Fraser M, Perera N, Rajakumar K, Zambon M.

Health Technol Assess. 2014 May;18(36):1-274, vii-viii. doi: 10.3310/hta18360.


False hope for Canadians who study medicine abroad.

Barer ML, Evans RG, Hedden L.

CMAJ. 2014 Apr 15;186(7):552. doi: 10.1503/cmaj.131704. Epub 2014 Mar 31. No abstract available. Erratum in: CMAJ. 2014 May 13;186(8):615.


The CARA tuberculosis project in Karbala.

Barer MR, Ahmed MM, Nasirallah HA, Ahmed S, Al-Zaag A.

Med Confl Surviv. 2013 Jan-Mar;29(1):75-6. No abstract available.


Health care services use in assisted living: a time series analysis.

McGrail KM, Lilly MB, McGregor MJ, Broemeling AM, Salomons K, Peterson S, McKendry R, Barer ML.

Can J Aging. 2013 Jun;32(2):173-83. doi: 10.1017/S0714980813000159. Epub 2013 May 23.


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