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Items: 1 to 20 of 134


Pcsk9 knockout exacerbates diet-induced non-alcoholic steatohepatitis, fibrosis and liver injury in mice.

Lebeau PF, Byun JH, Platko K, Al-Hashimi AA, Lhoták Š, MacDonald ME, Mejia-Benitez A, Prat A, Igdoura SA, Trigatti B, Maclean KN, Seidah NG, Austin RC.

JHEP Rep. 2019 Nov 5;1(6):418-429. doi: 10.1016/j.jhepr.2019.10.009. eCollection 2019 Dec.


GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury.

Platko K, Lebeau PF, Byun JH, Poon SV, Day EA, MacDonald ME, Holzapfel N, Mejia-Benitez A, Maclean KN, Krepinsky JC, Austin RC.

Mol Metab. 2019 Sep;27:62-74. doi: 10.1016/j.molmet.2019.06.021. Epub 2019 Jun 28.


The trypan blue cellular debris assay: a novel low-cost method for the rapid quantification of cell death.

Lebeau PF, Chen J, Byun JH, Platko K, Austin RC.

MethodsX. 2019 May 15;6:1174-1180. doi: 10.1016/j.mex.2019.05.010. eCollection 2019.


Teaching Opioid Tapering Through Guided Instruction.

Austin RC, Fusco CW, Fagan EB, Drake E, Pacious J, Dickens H, Galvin SL, Wilson CG.

Fam Med. 2019 May;51(5):434-437. doi: 10.22454/FamMed.2019.502509.


Diet-induced hepatic steatosis abrogates cell-surface LDLR by inducing de novo PCSK9 expression in mice.

Lebeau PF, Byun JH, Platko K, MacDonald ME, Poon SV, Faiyaz M, Seidah NG, Austin RC.

J Biol Chem. 2019 Jun 7;294(23):9037-9047. doi: 10.1074/jbc.RA119.008094. Epub 2019 Apr 19.


4-Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of Apoe-/- mice.

Lynn EG, Lhoták Š, Lebeau P, Byun JH, Chen J, Platko K, Shi C, O'Brien ER, Austin RC.

FASEB J. 2019 Jul;33(7):8406-8422. doi: 10.1096/fj.201802293RR. Epub 2019 Apr 9.


Cell surface expression of 78-kDa glucose-regulated protein (GRP78) mediates diabetic nephropathy.

Van Krieken R, Mehta N, Wang T, Zheng M, Li R, Gao B, Ayaub E, Ask K, Paton JC, Paton AW, Austin RC, Krepinsky JC.

J Biol Chem. 2019 May 10;294(19):7755-7768. doi: 10.1074/jbc.RA118.006939. Epub 2019 Mar 26.


Local inhibition of uptake2 transporters augments stress-induced increases in serotonin in the rat central amygdala.

Hassell JE Jr, Collins VE, Li H, Rogers JT, Austin RC, Visceau C, Nguyen KT, Orchinik M, Lowry CA, Renner KJ.

Neurosci Lett. 2019 May 14;701:119-124. doi: 10.1016/j.neulet.2019.02.022. Epub 2019 Feb 15.


GRP78 (Glucose-Regulated Protein of 78 kDa) Promotes Cardiomyocyte Growth Through Activation of GATA4 (GATA-Binding Protein 4).

Zhang G, Wang X, Bi X, Li C, Deng Y, Al-Hashimi AA, Luo X, Gillette TG, Austin RC, Wang Y, Wang ZV.

Hypertension. 2019 Feb;73(2):390-398. doi: 10.1161/HYPERTENSIONAHA.118.12084.


Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions.

Crane ED, Al-Hashimi AA, Chen J, Lynn EG, Won KD, Lhoták Š, Naeim M, Platko K, Lebeau P, Byun JH, Shayegan B, Krepinsky JC, Rayner KJ, Marchiò S, Pasqualini R, Arap W, Austin RC.

JCI Insight. 2018 Dec 20;3(24). pii: 99363. doi: 10.1172/jci.insight.99363.


IL-6 mediates ER expansion during hyperpolarization of alternatively activated macrophages.

Ayaub EA, Tandon K, Padwal M, Imani J, Patel H, Dubey A, Mekhael O, Upagupta C, Ayoub A, Dvorkin-Gheva A, Murphy J, Kolb PS, Lhotak S, Dickhout JG, Austin RC, Kolb MRJ, Richards CD, Ask K.

Immunol Cell Biol. 2019 Feb;97(2):203-217. doi: 10.1111/imcb.12212. Epub 2018 Nov 14.


Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice.

White EJ, Gyulay G, Lhoták Š, Szewczyk MM, Chong T, Fuller MT, Dadoo O, Fox-Robichaud AE, Austin RC, Trigatti BL, Igdoura SA.

J Biol Chem. 2018 Sep 21;293(38):14689-14706. doi: 10.1074/jbc.RA118.004589. Epub 2018 Aug 10.


MAPping the kinase landscape of macrophage activation.

Platko K, Lebeau P, Austin RC.

J Biol Chem. 2018 Jun 22;293(25):9910-9911. doi: 10.1074/jbc.H118.003380.


Thrombotic characteristics of extracellular vesicles derived from prostate cancer cells.

Al Saleh HA, Haas-Neill S, Al-Hashimi A, Kapoor A, Shayegan B, Austin RC, Al-Nedawi K.

Prostate. 2018 Sep;78(13):953-961. doi: 10.1002/pros.23653. Epub 2018 May 15.


Pharmacologic inhibition of S1P attenuates ATF6 expression, causes ER stress and contributes to apoptotic cell death.

Lebeau P, Byun JH, Yousof T, Austin RC.

Toxicol Appl Pharmacol. 2018 Jun 15;349:1-7. doi: 10.1016/j.taap.2018.04.020. Epub 2018 Apr 22.


Endoplasmic Reticulum Chaperone GRP78 Protects Heart From Ischemia/Reperfusion Injury Through Akt Activation.

Bi X, Zhang G, Wang X, Nguyen C, May HI, Li X, Al-Hashimi AA, Austin RC, Gillette TG, Fu G, Wang ZV, Hill JA.

Circ Res. 2018 May 25;122(11):1545-1554. doi: 10.1161/CIRCRESAHA.117.312641. Epub 2018 Apr 18.


Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained.

Lebeau P, Platko K, Al-Hashimi AA, Byun JH, Lhoták Š, Holzapfel N, Gyulay G, Igdoura SA, Cool DR, Trigatti B, Seidah NG, Austin RC.

J Biol Chem. 2018 May 11;293(19):7329-7343. doi: 10.1074/jbc.RA117.001049. Epub 2018 Mar 28.


Using cadaveric simulation to introduce the concept and skills required to start performing transanal total mesorectal excision.

Wynn GR, Austin RCT, Motson RW.

Colorectal Dis. 2018 Jun;20(6):496-501. doi: 10.1111/codi.14034.


Separate roles of IL-6 and oncostatin M in mouse macrophage polarization in vitro and in vivo.

Dubey A, Izakelian L, Ayaub EA, Ho L, Stephenson K, Wong S, Kwofie K, Austin RC, Botelho F, Ask K, Richards CD.

Immunol Cell Biol. 2018 Mar;96(3):257-272. doi: 10.1111/imcb.1035. Epub 2017 Dec 26.


Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering.

Yu P, Xiong T, Tenedero CB, Lebeau P, Ni R, MacDonald ME, Gross PL, Austin RC, Trigatti BL.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):26-39. doi: 10.1161/ATVBAHA.117.305140. Epub 2017 Nov 21.

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