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  • Showing results for augmentation of production of tnf-alpha and anti-tumour activity by an amphotericin b preparation for clinical use in mice. Your search for Augumentation of production of TNF-α and anti-tumour activity by an amphotericin B preparation for clinical use in mice retrieved no results.
Br J Cancer. 1997;75(11):1613-6.

Augmentation of production of TNF-alpha and anti-tumour activity by an amphotericin B preparation for clinical use in mice.

Author information

1
Department of Microbiology and Immunology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.

Abstract

Effects of amphotericin B on production of endogenous tumour necrosis factor alpha (TNF-alpha) and anti-tumour activity in mice was examined. Intravenous administration of Fungizone, an amphotericin B preparation complexed with deoxycholate, augmented the induction of endogenous TNF in response to a second stimulus with intravenous doses of FK23 (heat-killed Enterococcus faecalis). This augmentation was observed when more than 1.8 microg of Fungizone was injected intravenously before intravenous dosing of FK23. The time interval between priming injection of Fungizone and secondary injection of FK23 for the maximal effect was 3 h. Similar augmentation of TNF production was also observed in amphotericin B-primed and FK23-injected mice. Correspondingly, anti-tumour activity of the combined, intravenous injection of Fungizone and FK23 with a 3-h interval was examined. Growth of Meth A fibrosarcoma was clearly inhibited by this combination but not by administration of either one alone. These results suggest that amphotericin B is able to elicit anti-tumour activity, perhaps through activation of the immune system, and in particular augmentation of the induction of endogenous TNF.

PMID:
9184176
PMCID:
PMC2223546
[Indexed for MEDLINE]
Free PMC Article

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