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Items: 1 to 20 of 63

1.

Probing the ligand preferences of the three types of bacterial pantothenate kinase.

Guan J, Barnard L, Cresson J, Hoegl A, Chang JH, Strauss E, Auclair K.

Bioorg Med Chem. 2018 Dec 1;26(22):5896-5902. doi: 10.1016/j.bmc.2018.10.042. Epub 2018 Nov 2.

PMID:
30429095
2.

Structure-Activity Relationships of Antiplasmodial Pantothenamide Analogues Reveal a New Way by Which Triazoles Mimic Amide Bonds.

Guan J, Tjhin ET, Howieson VM, Kittikool T, Spry C, Saliba KJ, Auclair K.

ChemMedChem. 2018 Oct 29. doi: 10.1002/cmdc.201800327. [Epub ahead of print]

PMID:
30370998
3.

Cellular Studies of an Aminoglycoside Potentiator Reveal a New Inhibitor of Aminoglycoside Resistance.

Guan J, Vong K, Wee K, Fakhoury J, Dullaghan E, Auclair K.

Chembiochem. 2018 Oct 4;19(19):2107-2113. doi: 10.1002/cbic.201800368. Epub 2018 Sep 14.

PMID:
30059603
4.

Steroid bioconjugation to a CYP3A4 allosteric site and its effect on substrate binding and coupling efficiency.

Polic V, Sevrioukova IF, Auclair K.

Arch Biochem Biophys. 2018 Sep 1;653:90-96. doi: 10.1016/j.abb.2018.06.014. Epub 2018 Jun 26.

PMID:
29958895
5.

Electrophilic properties of itaconate and derivatives regulate the IκBζ-ATF3 inflammatory axis.

Bambouskova M, Gorvel L, Lampropoulou V, Sergushichev A, Loginicheva E, Johnson K, Korenfeld D, Mathyer ME, Kim H, Huang LH, Duncan D, Bregman H, Keskin A, Santeford A, Apte RS, Sehgal R, Johnson B, Amarasinghe GK, Soares MP, Satoh T, Akira S, Hai T, de Guzman Strong C, Auclair K, Roddy TP, Biller SA, Jovanovic M, Klechevsky E, Stewart KM, Randolph GJ, Artyomov MN.

Nature. 2018 Apr;556(7702):501-504. doi: 10.1038/s41586-018-0052-z. Epub 2018 Apr 18.

6.

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues.

Tjhin ET, Spry C, Sewell AL, Hoegl A, Barnard L, Sexton AE, Siddiqui G, Howieson VM, Maier AG, Creek DJ, Strauss E, Marquez R, Auclair K, Saliba KJ.

PLoS Pathog. 2018 Apr 3;14(4):e1006918. doi: 10.1371/journal.ppat.1006918. eCollection 2018 Apr.

7.

Solvent-Free Enzyme Activity: Quick, High-Yielding Mechanoenzymatic Hydrolysis of Cellulose into Glucose.

Hammerer F, Loots L, Do JL, Therien JPD, Nickels CW, Friščić T, Auclair K.

Angew Chem Int Ed Engl. 2018 Mar 1;57(10):2621-2624. doi: 10.1002/anie.201711643. Epub 2018 Feb 6.

PMID:
29342316
8.

Use of bioconjugation with cytochrome P450 enzymes.

Ducharme J, Auclair K.

Biochim Biophys Acta Proteins Proteom. 2018 Jan;1866(1):32-51. doi: 10.1016/j.bbapap.2017.06.007. Epub 2017 Jun 16. Review.

PMID:
28625736
9.

Allosteric Activation of Cytochrome P450 3A4 via Progesterone Bioconjugation.

Polic V, Auclair K.

Bioconjug Chem. 2017 Apr 19;28(4):885-889. doi: 10.1021/acs.bioconjchem.6b00604. Epub 2017 Mar 29.

PMID:
28339191
10.

Enzymes Beat Chemists in the Formation of an Unnatural Bond.

Ducharme J, Auclair K.

Chembiochem. 2017 Mar 2;18(5):432-434. doi: 10.1002/cbic.201600692. Epub 2017 Feb 7.

PMID:
28026102
11.

Active Site Crowding of Cytochrome P450 3A4 as a Strategy To Alter Its Selectivity.

Schiavini P, Cheong KJ, Moitessier N, Auclair K.

Chembiochem. 2017 Feb 1;18(3):248-252. doi: 10.1002/cbic.201600546. Epub 2016 Dec 15.

PMID:
27897366
12.

Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency.

Howieson VM, Tran E, Hoegl A, Fam HL, Fu J, Sivonen K, Li XX, Auclair K, Saliba KJ.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7146-7152. Print 2016 Dec.

13.

A cross-metathesis approach to novel pantothenamide derivatives.

Guan J, Hachey M, Puri L, Howieson V, Saliba KJ, Auclair K.

Beilstein J Org Chem. 2016 May 13;12:963-8. doi: 10.3762/bjoc.12.95. eCollection 2016.

14.

Small Molecule Restores Itaconate Sensitivity in Salmonella enterica: A Potential New Approach to Treating Bacterial Infections.

Hammerer F, Chang JH, Duncan D, Castañeda Ruiz A, Auclair K.

Chembiochem. 2016 Aug 17;17(16):1513-7. doi: 10.1002/cbic.201600078. Epub 2016 Jun 30.

PMID:
27254798
15.

3-Oxo-hexahydro-1H-isoindole-4-carboxylic Acid as a Drug Chiral Bicyclic Scaffold: Structure-Based Design and Preparation of Conformationally Constrained Covalent and Noncovalent Prolyl Oligopeptidase Inhibitors.

Mariaule G, De Cesco S, Airaghi F, Kurian J, Schiavini P, Rocheleau S, Huskić I, Auclair K, Mittermaier A, Moitessier N.

J Med Chem. 2016 May 12;59(9):4221-34. doi: 10.1021/acs.jmedchem.5b01296. Epub 2015 Dec 14.

PMID:
26619267
16.

Metabolic Instability of Cyanothiazolidine-Based Prolyl Oligopeptidase Inhibitors: a Structural Assignment Challenge and Potential Medicinal Chemistry Implications.

Schiavini P, Pottel J, Moitessier N, Auclair K.

ChemMedChem. 2015 Jul;10(7):1174-83. doi: 10.1002/cmdc.201500114. Epub 2015 May 28.

17.

Use of chemical auxiliaries to control p450 enzymes for predictable oxidations at unactivated C-h bonds of substrates.

Auclair K, Polic V.

Adv Exp Med Biol. 2015;851:209-28. doi: 10.1007/978-3-319-16009-2_8. Review.

18.

Global ITC fitting methods in studies of protein allostery.

Freiburger L, Auclair K, Mittermaier A.

Methods. 2015 Apr;76:149-161. doi: 10.1016/j.ymeth.2014.12.018. Epub 2015 Jan 5. Review.

19.

Substrate-dependent switching of the allosteric binding mechanism of a dimeric enzyme.

Freiburger L, Miletti T, Zhu S, Baettig O, Berghuis A, Auclair K, Mittermaier A.

Nat Chem Biol. 2014 Nov;10(11):937-42. doi: 10.1038/nchembio.1626. Epub 2014 Sep 14.

PMID:
25218742
20.

Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis.

Polic V, Auclair K.

Bioorg Med Chem. 2014 Oct 15;22(20):5547-54. doi: 10.1016/j.bmc.2014.06.034. Epub 2014 Jun 25. Review.

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