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Items: 1 to 20 of 48


Phosphatidylserine improves axonal transport by inhibition of HDAC and has potential in treatment of neurodegenerative diseases.

Naftelberg S, Ast G, Perlson E.

Neural Regen Res. 2017 Apr;12(4):534-537. doi: 10.4103/1673-5374.205082. Review.


Phosphatidylserine Ameliorates Neurodegenerative Symptoms and Enhances Axonal Transport in a Mouse Model of Familial Dysautonomia.

Naftelberg S, Abramovitch Z, Gluska S, Yannai S, Joshi Y, Donyo M, Ben-Yaakov K, Gradus T, Zonszain J, Farhy C, Ashery-Padan R, Perlson E, Ast G.

PLoS Genet. 2016 Dec 20;12(12):e1006486. doi: 10.1371/journal.pgen.1006486. eCollection 2016 Dec.


A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1.

Hollander D, Donyo M, Atias N, Mekahel K, Melamed Z, Yannai S, Lev-Maor G, Shilo A, Schwartz S, Barshack I, Sharan R, Ast G.

Genome Res. 2016 Apr;26(4):541-53. doi: 10.1101/gr.193169.115. Epub 2016 Feb 9.


Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate.

Fuchs G, Hollander D, Voichek Y, Ast G, Oren M.

Genome Res. 2014 Oct;24(10):1572-83. doi: 10.1101/gr.176487.114. Epub 2014 Jul 21.


DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon-intron structure.

Gelfman S, Cohen N, Yearim A, Ast G.

Genome Res. 2013 May;23(5):789-99. doi: 10.1101/gr.143503.112. Epub 2013 Mar 15.


Pre-mRNA splicing is a determinant of nucleosome organization.

Keren-Shaul H, Lev-Maor G, Ast G.

PLoS One. 2013;8(1):e53506. doi: 10.1371/journal.pone.0053506. Epub 2013 Jan 10.


Changes in exon-intron structure during vertebrate evolution affect the splicing pattern of exons.

Gelfman S, Burstein D, Penn O, Savchenko A, Amit M, Schwartz S, Pupko T, Ast G.

Genome Res. 2012 Jan;22(1):35-50. doi: 10.1101/gr.119834.110. Epub 2011 Oct 5.


Detection and removal of biases in the analysis of next-generation sequencing reads.

Schwartz S, Oren R, Ast G.

PLoS One. 2011 Jan 31;6(1):e16685. doi: 10.1371/journal.pone.0016685.


Phosphatidylserine increases IKBKAP levels in familial dysautonomia cells.

Keren H, Donyo M, Zeevi D, Maayan C, Pupko T, Ast G.

PLoS One. 2010 Dec 29;5(12):e15884. doi: 10.1371/journal.pone.0015884.


Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB.

Llorian M, Schwartz S, Clark TA, Hollander D, Tan LY, Spellman R, Gordon A, Schweitzer AC, de la Grange P, Ast G, Smith CW.

Nat Struct Mol Biol. 2010 Sep;17(9):1114-23. doi: 10.1038/nsmb.1881. Epub 2010 Aug 15.


Characteristics of transposable element exonization within human and mouse.

Sela N, Mersch B, Hotz-Wagenblatt A, Ast G.

PLoS One. 2010 Jun 1;5(6):e10907. doi: 10.1371/journal.pone.0010907.


The role of transposable elements in the evolution of non-mammalian vertebrates and invertebrates.

Sela N, Kim E, Ast G.

Genome Biol. 2010;11(6):R59. doi: 10.1186/gb-2010-11-6-r59. Epub 2010 Jun 2.


Chromatin density and splicing destiny: on the cross-talk between chromatin structure and splicing.

Schwartz S, Ast G.

EMBO J. 2010 May 19;29(10):1629-36. doi: 10.1038/emboj.2010.71. Epub 2010 Apr 20.


Overlapping splicing regulatory motifs--combinatorial effects on splicing.

Goren A, Kim E, Amit M, Vaknin K, Kfir N, Ram O, Ast G.

Nucleic Acids Res. 2010 Jun;38(10):3318-27. doi: 10.1093/nar/gkq005. Epub 2010 Jan 27.


Large-scale discovery of insertion hotspots and preferential integration sites of human transposed elements.

Levy A, Schwartz S, Ast G.

Nucleic Acids Res. 2010 Mar;38(5):1515-30. doi: 10.1093/nar/gkp1134. Epub 2009 Dec 14.


The pivotal roles of TIA proteins in 5' splice-site selection of alu exons and across evolution.

Gal-Mark N, Schwartz S, Ram O, Eyras E, Ast G.

PLoS Genet. 2009 Nov;5(11):e1000717. doi: 10.1371/journal.pgen.1000717. Epub 2009 Nov 13.


TEs or not TEs? That is the evolutionary question.

Vaknin K, Goren A, Ast G.

J Biol. 2009 Oct 23;8(9):83. doi: 10.1186/jbiol188.


SROOGLE: webserver for integrative, user-friendly visualization of splicing signals.

Schwartz S, Hall E, Ast G.

Nucleic Acids Res. 2009 Jul;37(Web Server issue):W189-92. doi: 10.1093/nar/gkp320. Epub 2009 May 8.


Alu exonization events reveal features required for precise recognition of exons by the splicing machinery.

Schwartz S, Gal-Mark N, Kfir N, Oren R, Kim E, Ast G.

PLoS Comput Biol. 2009 Mar;5(3):e1000300. doi: 10.1371/journal.pcbi.1000300. Epub 2009 Mar 6.


Transduplication resulted in the incorporation of two protein-coding sequences into the turmoil-1 transposable element of C. elegans.

Sela N, Stern A, Makalowski W, Pupko T, Ast G.

Biol Direct. 2008 Oct 8;3:41. doi: 10.1186/1745-6150-3-41.

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