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Eur Heart J Cardiovasc Imaging. 2016 Aug;17(8):909-17. doi: 10.1093/ehjci/jev215. Epub 2015 Sep 10.

Reproducibility of functional aortic analysis using magnetic resonance imaging: the MESA.

Author information

1
Department of Cardiology, Johns Hopkins University, Baltimore, MD 21287, USA.
2
Department of Radiology, Johns Hopkins University, Baltimore, MD 21287, USA.
3
Radiology and Imaging Sciences, National Institutes of Health/Clinical Center, Bethesda, MD 20892, USA.
4
Groupe Hospitalier La Pitié Salpêtrière Sorbonne Universités, UPMC and Laboratoire D'imagerie Fonctionnelle LIB INSERM (UMR-S 1146), ICAN Imaging Core Lab, Paris, France.
5
Vall d'Hebron Hospital, Barcelona, Spain.
6
Department of Cardiology, Jewish Hospital, Louisville, KY 40202, USA.
7
National Institutes of Health/Office of Biostatistics Research, National Heart, Lung and Blood Institute, Bethesda, MD 20892-7913, USA.
8
Department of Internal Medicine/Cardiology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA.
9
Department of Cardiology, Johns Hopkins University, Baltimore, MD 21287, USA Department of Medicine and Radiology, Johns Hopkins Hospital, 600 North Wolfe Street, Blalock 524D1, Baltimore, MD 21287, USA jlima@jhmi.edu.

Abstract

AIMS:

To assess the test-retest, intra- and inter-reader reliability of thoracic aorta measurements by magnetic resonance imaging (MRI).

METHODS AND RESULTS:

Twenty-five participants underwent aortic MRI twice over 13 ± 7 days. All aortic variables from baseline and repeat MR were analysed using a semi-automated method by the ARTFUN software. To assess the inter-study reproducibility of aortic variables, we calculated intraclass correlation coefficient (ICC) for individual aortic measurements. Intra- and inter-observer variability was also assessed using the baseline MR data. Mean ascending aortic strain had moderate inter-study reproducibility (11.53 ± 6.44 vs. 10.55 ± 6.64, P = 0.443, ICC = 0.53, P < 0.01). Mean descending aortic strain and arch pulse wave velocity (PWV) had good inter-study reproducibility (descending aortic strain: 8.65 ± 5.30 vs. 8.35 ± 5.26, P = 0.706, ICC = 0.74, P < 0.001; PWV: 9.92 ± 4.18 vs. 9.94 ± 4.55, P = 0.968, ICC = 0.77, P < 0.001, respectively). All aortic variables had excellent intra- and inter-observer reproducibility (intra-: ICC range, 0.87-0.99, inter-: ICC range, 0.56-0.99, respectively).

CONCLUSION:

Inter-study reproducibility of all aortic variables was acceptable. Intra- and inter-observer reproducibility of all aortic variables was excellent. MRI can provide a repeatable method of measuring aortic structural and functional parameters.

KEYWORDS:

MRI; aorta; phase contrast; pulse wave velocity; reproducibility; strain

PMID:
26358693
PMCID:
PMC4955291
DOI:
10.1093/ehjci/jev215
[Indexed for MEDLINE]
Free PMC Article

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