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Items: 1 to 20 of 23


Computational site-directed mutagenesis studies of the role of the hydrophobic triad on substrate binding in cholesterol oxidase.

Harb LH, Arooj M, Vrielink A, Mancera RL.

Proteins. 2017 May 15. doi: 10.1002/prot.25319. [Epub ahead of print]


Erdheim-Chester disease associated with a novel, complex BRAF p.Thr599_Val600delinsArgGlu mutation.

Bentel JM, Thomas MA, Rodgers JJ, Arooj M, Gray E, Allcock R, Fermoyle S, Mancera RL, Cannell P, Parry J.

BMJ Case Rep. 2017 Apr 28;2017. pii: bcr-2017-219720. doi: 10.1136/bcr-2017-219720.


Implications of prognostic variables in the assessment of autoimmunity in hepatitis C patients receiving interferon therapy.

Arooj M, Malik A, Basit A, Husain Qazi M, Asif M, Sarwar Jamal M, Mostafa Mahmoud M, Choudhry H, Natesan Pushparaj P, Rasool M.

Bioinformation. 2016 Jun 15;12(3):131-134. doi: 10.6026/97320630012131. eCollection 2016.


Waking up dormant tumor suppressor genes with zinc fingers, TALEs and the CRISPR/dCas9 system.

Garcia-Bloj B, Moses C, Sgro A, Plani-Lam J, Arooj M, Duffy C, Thiruvengadam S, Sorolla A, Rashwan R, Mancera RL, Leisewitz A, Swift-Scanlan T, Corvalan AH, Blancafort P.

Oncotarget. 2016 Sep 13;7(37):60535-60554. doi: 10.18632/oncotarget.11142.


Adsorption and Unfolding of Lysozyme at a Polarized Aqueous-Organic Liquid Interface.

Arooj M, Gandhi NS, Kreck CA, Arrigan DW, Mancera RL.

J Phys Chem B. 2016 Mar 31;120(12):3100-12. doi: 10.1021/acs.jpcb.6b00536. Epub 2016 Mar 18.


Assessment of biochemical and antioxidative status in patients suffering from dengue fever.

Rasool M, Malik A, Khan KM, Qureshi MS, Shabbir B, Zahid S, Asif M, Manan A, Rashid S, Khan SR, Arsalan HM, Alam R, Arooj M, Qazi MH, Chaudhary AG, Abuzenadah AM, Al-Qahtani MH, Karim S.

J Huazhong Univ Sci Technolog Med Sci. 2015 Jun;35(3):411-8. doi: 10.1007/s11596-015-1446-x. Epub 2015 Jun 14.


A lazy learning-based QSAR classification study for screening potential histone deacetylase 8 (HDAC8) inhibitors.

Cao GP, Arooj M, Thangapandian S, Park C, Arulalapperumal V, Kim Y, Kwon YJ, Kim HH, Suh JK, Lee KW.

SAR QSAR Environ Res. 2015;26(5):397-420. doi: 10.1080/1062936X.2015.1040453.


Roles of Natural Compounds from Medicinal Plants in Cancer Treatment: Structure and Mode of Action at Molecular Level.

Rasool M, Malik A, Manan A, Arooj M, Qazi MH, Kamal MA, Sheikh IA, Gan SH, Asif M, Naseer MI.

Med Chem. 2015;11(7):618-28. Review.


Finding off-targets, biological pathways, and target diseases for chymase inhibitors via structure-based systems biology approach.

Arooj M, Sakkiah S, Cao GP, Kim S, Arulalapperumal V, Lee KW.

Proteins. 2015 Jul;83(7):1209-24. doi: 10.1002/prot.24677. Epub 2015 May 4.


New possibilities in hepatocellular carcinoma treatment.

Rasool M, Rashid S, Arooj M, Ansari SA, Khan KM, Malik A, Naseer MI, Zahid S, Manan A, Asif M, Razzaq Z, Ashraf S, Qazi MH, Iqbal Z, Gan SH, Kamal MA, Sheikh IA.

Anticancer Res. 2014 Apr;34(4):1563-71. Review.


Binding mode analyses and pharmacophore model development for stilbene derivatives as a novel and competitive class of α-glucosidase inhibitors.

Lee Y, Kim S, Kim JY, Arooj M, Kim S, Hwang S, Kim BW, Park KH, Lee KW.

PLoS One. 2014 Jan 21;9(1):e85827. doi: 10.1371/journal.pone.0085827. eCollection 2014.


Orbital interaction and electron density transfer in PdII([9]aneB2A)L2 complexes: theoretical approaches.

Kwak OK, Arooj M, Yoon YJ, Jeong ED, Park JK.

Molecules. 2013 Oct 14;18(10):12687-706. doi: 10.3390/molecules181012687.


A combination of receptor-based pharmacophore modeling & QM techniques for identification of human chymase inhibitors.

Arooj M, Sakkiah S, Kim S, Arulalapperumal V, Lee KW.

PLoS One. 2013 Apr 26;8(4):e63030. doi: 10.1371/journal.pone.0063030. Print 2013.


Molecular modeling study for inhibition mechanism of human chymase and its application in inhibitor design.

Arooj M, Kim S, Sakkiah S, Cao GP, Lee Y, Lee KW.

PLoS One. 2013 Apr 25;8(4):e62740. doi: 10.1371/journal.pone.0062740. Print 2013.


An innovative strategy for dual inhibitor design and its application in dual inhibition of human thymidylate synthase and dihydrofolate reductase enzymes.

Arooj M, Sakkiah S, Cao Gp, Lee KW.

PLoS One. 2013;8(4):e60470. doi: 10.1371/journal.pone.0060470. Epub 2013 Apr 5.


Insight the C-site pocket conformational changes responsible for sirtuin 2 activity using molecular dynamics simulations.

Sakkiah S, Arooj M, Cao GP, Lee KW.

PLoS One. 2013;8(3):e59278. doi: 10.1371/journal.pone.0059278. Epub 2013 Mar 20.


Identification of inhibitor binding site in human sirtuin 2 using molecular docking and dynamics simulations.

Sakkiah S, Arooj M, Kumar MR, Eom SH, Lee KW.

PLoS One. 2013;8(1):e51429. doi: 10.1371/journal.pone.0051429. Epub 2013 Jan 28.


Molecular characterization of FLT3 mutations in acute leukemia patients in Pakistan.

Ishfaq M, Malik A, Faiz M, Sheikh I, Asif M, Khan MN, Qureshi MS, Zahid S, Manan A, Arooj M, Qazi MH, Chaudhary A, Alqahtani MH, Rasool M.

Asian Pac J Cancer Prev. 2012;13(9):4581-5.


Computational studies of novel chymase inhibitors against cardiovascular and allergic diseases: mechanism and inhibition.

Arooj M, Thangapandian S, John S, Hwang S, Park JK, Lee KW.

Chem Biol Drug Des. 2012 Dec;80(6):862-75. doi: 10.1111/cbdd.12006.


Molecular dynamics simulation study and hybrid pharmacophore model development in human LTA4H inhibitor design.

Thangapandian S, John S, Arooj M, Lee KW.

PLoS One. 2012;7(4):e34593. doi: 10.1371/journal.pone.0034593. Epub 2012 Apr 5.

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