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Forsch Komplementmed. 2006 Feb;13 Suppl 1:13-7. Epub 2006 Feb 17.

Anti-inflammatory mechanisms of the Tibetan herbal preparation Padma 28 in the vessel wall.

Author information

1
Klinisches Institut für Medizinische und Chemische Labordiagnostik, Institut für Medizinische Chemie, Medizinische Universität Wien, Austria. markus.exner@meduniwien.ac.at

Abstract

BACKGROUND:

The Tibetan herbal preparation Padma 28 has been shown to act as an anti-atherosclerotic agent in advanced peripheral arterial occlusive disease. We tested the effect of aqueous Padma 28 extracts on both the Creactive protein (CRP) induced expression of the pro-inflammatory cell adhesion molecule E-selectin and the anti-atherosclerotic protective enzyme heme oxygenase- 1 (HO-1) in human aortic endothelial cells.

METHODS AND RESULTS:

According to FACS analysis, quantitative RT-PCR and Western blot, CRP-induced E-selectin expression was completely prevented by aqueous Padma 28 extracts. Additionally, Padma 28 mediated an up to 60-fold upregulation of HO-1 mRNA as measured by quantitative RT-PCR. This upregulation could also be demonstrated on the protein level.

CONCLUSION:

Aqueous extracts of the Tibetan herbal preparation Padma 28 inhibit CRP-induced expression of the inflammatory cell adhesion molecule E-selectin and lead to upregulation of the vascular protective enzyme HO-1 in human aortic endothelial cells. These properties may be responsible for its anti-atherosclerotic effects in peripheral arterial occlusive disease.

PMID:
16582558
DOI:
10.1159/000090435
[Indexed for MEDLINE]

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