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J Biomed Biotechnol. 2010;2010:709378. doi: 10.1155/2010/709378. Epub 2010 Mar 17.

Anti-inflammatory effects of licorice and roasted licorice extracts on TPA-induced acute inflammation and collagen-induced arthritis in mice.

Author information

1
Department of Oral Biology, Research Center for Orofacial Hard Tissue Regeneration, Oral Science Research Institute and Brain Korea 21 Project, Yonsei University College of Dentistry, 250 Seongsanno, Seodaemun-Ku, Seoul 120-752, South Korea.

Abstract

The anti-inflammatory activity of licorice (LE) and roasted licorice (rLE) extracts determined in the murine phorbol ester-induced acute inflammation model and collagen-induced arthritis (CIA) model of human rheumatoid arthritis. rLE possessed greater activity than LE in inhibiting phorbol ester-induced ear edema. Oral administration of LE or rLE reduced clinical arthritis score, paw swelling, and histopathological changes in a murine CIA. LE and rLE decreased the levels of proinflammatory cytokines in serum and matrix metalloproteinase-3 expression in the joints. Cell proliferation and cytokine secretion in response to type II collagen or lipopolysaccharide stimulation were suppressed in spleen cells from LE or rLE-treated CIA mice. Furthermore, LE and rLE treatment prevented oxidative damages in liver and kidney tissues of CIA mice. Taken together, LE and rLE have benefits in protecting against both acute inflammation and chronic inflammatory conditions including rheumatoid arthritis. rLE may inhibit the acute inflammation more potently than LE.

PMID:
20300198
PMCID:
PMC2841253
DOI:
10.1155/2010/709378
[Indexed for MEDLINE]
Free PMC Article

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