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Items: 6

1.

NANOG amplifies STAT3 activation and they synergistically induce the naive pluripotent program.

Stuart HT, van Oosten AL, Radzisheuskaya A, Martello G, Miller A, Dietmann S, Nichols J, Silva JC.

Curr Biol. 2014 Feb 3;24(3):340-6. doi: 10.1016/j.cub.2013.12.040. Epub 2014 Jan 23.

2.

JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency.

van Oosten AL, Costa Y, Smith A, Silva JC.

Nat Commun. 2012 May 8;3:817. doi: 10.1038/ncomms1822.

3.

Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain.

Theunissen TW, Costa Y, Radzisheuskaya A, van Oosten AL, Lavial F, Pain B, Castro LF, Silva JC.

Development. 2011 Nov;138(22):4853-65. doi: 10.1242/dev.068775.

4.

Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions.

Theunissen TW, van Oosten AL, Castelo-Branco G, Hall J, Smith A, Silva JC.

Curr Biol. 2011 Jan 11;21(1):65-71. doi: 10.1016/j.cub.2010.11.074. Epub 2010 Dec 30.

5.

Stat3 activation is limiting for reprogramming to ground state pluripotency.

Yang J, van Oosten AL, Theunissen TW, Guo G, Silva JC, Smith A.

Cell Stem Cell. 2010 Sep 3;7(3):319-28. doi: 10.1016/j.stem.2010.06.022.

6.

Nanog is the gateway to the pluripotent ground state.

Silva J, Nichols J, Theunissen TW, Guo G, van Oosten AL, Barrandon O, Wray J, Yamanaka S, Chambers I, Smith A.

Cell. 2009 Aug 21;138(4):722-37. doi: 10.1016/j.cell.2009.07.039.

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