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Items: 1 to 20 of 250

1.

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing.

Yin H, Song CQ, Suresh S, Wu Q, Walsh S, Rhym LH, Mintzer E, Bolukbasi MF, Zhu LJ, Kauffman K, Mou H, Oberholzer A, Ding J, Kwan SY, Bogorad RL, Zatsepin T, Koteliansky V, Wolfe SA, Xue W, Langer R, Anderson DG.

Nat Biotechnol. 2017 Nov 13. doi: 10.1038/nbt.4005. [Epub ahead of print]

PMID:
29131148
2.

Identification of cell cycle-targeting microRNAs through genome-wide screens.

Hydbring P, Wang Y, Bogorad RL, Yin H, Anderson DG, Li C, Sicinski P.

Cell Cycle. 2017 Nov 3:1-8. doi: 10.1080/15384101.2017.1380132. [Epub ahead of print]

PMID:
29099267
3.

Glucose-responsive insulin by molecular and physical design.

Bakh NA, Cortinas AB, Weiss MA, Langer RS, Anderson DG, Gu Z, Dutta S, Strano MS.

Nat Chem. 2017 Sep 22;9(10):937-943. doi: 10.1038/nchem.2857.

PMID:
28937662
4.

Large-Scale Quantitative Proteomics Identifies the Ubiquitin Ligase Nedd4-1 as an Essential Regulator of Liver Regeneration.

Bachofner M, Speicher T, Bogorad RL, Muzumdar S, Derrer CP, Hürlimann F, Böhm F, Nanni P, Kockmann T, Kachaylo E, Meyer M, Padrissa-Altés S, Graf R, Anderson DG, Koteliansky V, Auf dem Keller U, Werner S.

Dev Cell. 2017 Sep 25;42(6):616-625.e8. doi: 10.1016/j.devcel.2017.07.025. Epub 2017 Sep 7.

PMID:
28890072
5.

Multiplexed RNAi therapy against brain tumor-initiating cells via lipopolymeric nanoparticle infusion delays glioblastoma progression.

Yu D, Khan OF, Suvà ML, Dong B, Panek WK, Xiao T, Wu M, Han Y, Ahmed AU, Balyasnikova IV, Zhang HF, Sun C, Langer R, Anderson DG, Lesniak MS.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6147-E6156. doi: 10.1073/pnas.1701911114. Epub 2017 Jul 10.

PMID:
28696296
6.

Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy.

Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK, Fukumura D.

J Clin Invest. 2017 Aug 1;127(8):3039-3051. doi: 10.1172/JCI93182. Epub 2017 Jul 10.

7.

Synthesis and Biological Evaluation of Ionizable Lipid Materials for the In Vivo Delivery of Messenger RNA to B Lymphocytes.

Fenton OS, Kauffman KJ, Kaczmarek JC, McClellan RL, Jhunjhunwala S, Tibbitt MW, Zeng MD, Appel EA, Dorkin JR, Mir FF, Yang JH, Oberli MA, Heartlein MW, DeRosa F, Langer R, Anderson DG.

Adv Mater. 2017 Sep;29(33). doi: 10.1002/adma.201606944. Epub 2017 Jul 6.

PMID:
28681930
8.

Advances in the delivery of RNA therapeutics: from concept to clinical reality.

Kaczmarek JC, Kowalski PS, Anderson DG.

Genome Med. 2017 Jun 27;9(1):60. doi: 10.1186/s13073-017-0450-0. Review.

9.

Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins.

Yang NJ, Kauke MJ, Sun F, Yang LF, Maass KF, Traxlmayr MW, Yu Y, Xu Y, Langer RS, Anderson DG, Wittrup KD.

Nucleic Acids Res. 2017 Jul 27;45(13):7602-7614. doi: 10.1093/nar/gkx546.

10.

Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing.

Vollmann EH, Cao L, Amatucci A, Reynolds T, Hamann S, Dalkilic-Liddle I, Cameron TO, Hossbach M, Kauffman KJ, Mir FF, Anderson DG, Novobrantseva T, Koteliansky V, Kisseleva T, Brenner D, Duffield J, Burkly LC.

Mol Ther Nucleic Acids. 2017 Jun 16;7:314-323. doi: 10.1016/j.omtn.2017.04.014. Epub 2017 Apr 20.

11.

CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion.

Mou H, Smith JL, Peng L, Yin H, Moore J, Zhang XO, Song CQ, Sheel A, Wu Q, Ozata DM, Li Y, Anderson DG, Emerson CP, Sontheimer EJ, Moore MJ, Weng Z, Xue W.

Genome Biol. 2017 Jun 14;18(1):108. doi: 10.1186/s13059-017-1237-8.

12.

Cell-Cycle-Targeting MicroRNAs as Therapeutic Tools against Refractory Cancers.

Hydbring P, Wang Y, Fassl A, Li X, Matia V, Otto T, Choi YJ, Sweeney KE, Suski JM, Yin H, Bogorad RL, Goel S, Yuzugullu H, Kauffman KJ, Yang J, Jin C, Li Y, Floris D, Swanson R, Ng K, Sicinska E, Anders L, Zhao JJ, Polyak K, Anderson DG, Li C, Sicinski P.

Cancer Cell. 2017 Apr 10;31(4):576-590.e8. doi: 10.1016/j.ccell.2017.03.004.

PMID:
28399412
13.

Delivery technologies for genome editing.

Yin H, Kauffman KJ, Anderson DG.

Nat Rev Drug Discov. 2017 Jun;16(6):387-399. doi: 10.1038/nrd.2016.280. Epub 2017 Mar 24. Review.

PMID:
28337020
14.

Comprehensive proteomic characterization of stem cell-derived extracellular matrices.

Ragelle H, Naba A, Larson BL, Zhou F, Prijić M, Whittaker CA, Del Rosario A, Langer R, Hynes RO, Anderson DG.

Biomaterials. 2017 Jun;128:147-159. doi: 10.1016/j.biomaterials.2017.03.008. Epub 2017 Mar 7.

PMID:
28327460
15.

An RNA nanoparticle vaccine against Zika virus elicits antibody and CD8+ T cell responses in a mouse model.

Chahal JS, Fang T, Woodham AW, Khan OF, Ling J, Anderson DG, Ploegh HL.

Sci Rep. 2017 Mar 21;7(1):252. doi: 10.1038/s41598-017-00193-w.

16.

Colony stimulating factor-1 receptor is a central component of the foreign body response to biomaterial implants in rodents and non-human primates.

Doloff JC, Veiseh O, Vegas AJ, Tam HH, Farah S, Ma M, Li J, Bader A, Chiu A, Sadraei A, Aresta-Dasilva S, Griffin M, Jhunjhunwala S, Webber M, Siebert S, Tang K, Chen M, Langan E, Dholokia N, Thakrar R, Qi M, Oberholzer J, Greiner DL, Langer R, Anderson DG.

Nat Mater. 2017 Jun;16(6):671-680. doi: 10.1038/nmat4866. Epub 2017 Mar 20.

17.

Mixed Reversible Covalent Crosslink Kinetics Enable Precise, Hierarchical Mechanical Tuning of Hydrogel Networks.

Yesilyurt V, Ayoob AM, Appel EA, Borenstein JT, Langer R, Anderson DG.

Adv Mater. 2017 May;29(19). doi: 10.1002/adma.201605947. Epub 2017 Mar 15.

PMID:
28295624
18.

Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy.

Oberli MA, Reichmuth AM, Dorkin JR, Mitchell MJ, Fenton OS, Jaklenec A, Anderson DG, Langer R, Blankschtein D.

Nano Lett. 2017 Mar 8;17(3):1326-1335. doi: 10.1021/acs.nanolett.6b03329. Epub 2016 Dec 5.

PMID:
28273716
19.

Barcoded nanoparticles for high throughput in vivo discovery of targeted therapeutics.

Dahlman JE, Kauffman KJ, Xing Y, Shaw TE, Mir FF, Dlott CC, Langer R, Anderson DG, Wang ET.

Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2060-2065. doi: 10.1073/pnas.1620874114. Epub 2017 Feb 6.

20.

Microfluidic Fabrication of Colloidal Nanomaterials-Encapsulated Microcapsules for Biomolecular Sensing.

Xie X, Zhang W, Abbaspourrad A, Ahn J, Bader A, Bose S, Vegas A, Lin J, Tao J, Hang T, Lee H, Iverson N, Bisker G, Li L, Strano MS, Weitz DA, Anderson DG.

Nano Lett. 2017 Mar 8;17(3):2015-2020. doi: 10.1021/acs.nanolett.7b00026. Epub 2017 Feb 6.

PMID:
28152589

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