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Items: 10


N-linked glycosylation of Kv1.2 voltage-gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels.

Thayer DA, Yang SB, Jan YN, Jan LY.

J Physiol. 2016 Jul 5. doi: 10.1113/JP272394. [Epub ahead of print]


Engineering Highly Potent and Selective Microproteins against Nav1.7 Sodium Channel for Treatment of Pain.

Shcherbatko A, Rossi A, Foletti D, Zhu G, Bogin O, Galindo Casas M, Rickert M, Hasa-Moreno A, Bartsevich V, Crameri A, Steiner AR, Henningsen R, Gill A, Pons J, Shelton DL, Rajpal A, Strop P.

J Biol Chem. 2016 Jul 1;291(27):13974-86. doi: 10.1074/jbc.M116.725978. Epub 2016 Apr 22.


Extension of in vivo half-life of biologically active molecules by XTEN protein polymers.

Podust VN, Balan S, Sim BC, Coyle MP, Ernst U, Peters RT, Schellenberger V.

J Control Release. 2016 Oct 28;240:52-66. doi: 10.1016/j.jconrel.2015.10.038.


Multivalent antiviral XTEN-peptide conjugates with long in vivo half-life and enhanced solubility.

Ding S, Song M, Sim BC, Gu C, Podust VN, Wang CW, McLaughlin B, Shah TP, Lax R, Gast R, Sharan R, Vasek A, Hartman MA, Deniston C, Srinivas P, Schellenberger V.

Bioconjug Chem. 2014 Jul 16;25(7):1351-9. doi: 10.1021/bc500215m. Epub 2014 Jun 23.


Extension of in vivo half-life of biologically active peptides via chemical conjugation to XTEN protein polymer.

Podust VN, Sim BC, Kothari D, Henthorn L, Gu C, Wang CW, McLaughlin B, Schellenberger V.

Protein Eng Des Sel. 2013 Nov;26(11):743-53. doi: 10.1093/protein/gzt048. Epub 2013 Oct 16.


GLP2-2G-XTEN: a pharmaceutical protein with improved serum half-life and efficacy in a rat Crohn's disease model.

Alters SE, McLaughlin B, Spink B, Lachinyan T, Wang CW, Podust V, Schellenberger V, Stemmer WP.

PLoS One. 2012;7(11):e50630. doi: 10.1371/journal.pone.0050630. Epub 2012 Nov 26. Corrected and republished in: PLoS One. 2013;8(6). doi: 10.1371/annotation/5c7138bd-5602-466d-8daf-e75e0b7d7fdb.


Gcg-XTEN: an improved glucagon capable of preventing hypoglycemia without increasing baseline blood glucose.

Geething NC, To W, Spink BJ, Scholle MD, Wang CW, Yin Y, Yao Y, Schellenberger V, Cleland JL, Stemmer WP, Silverman J.

PLoS One. 2010 Apr 14;5(4):e10175. doi: 10.1371/journal.pone.0010175.


A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner.

Schellenberger V, Wang CW, Geething NC, Spink BJ, Campbell A, To W, Scholle MD, Yin Y, Yao Y, Bogin O, Cleland JL, Silverman J, Stemmer WP.

Nat Biotechnol. 2009 Dec;27(12):1186-90. doi: 10.1038/nbt.1588. Epub .


Peptide ligands specific to the oxidized form of Escherichia coli thioredoxin.

Scholle MD, Banach BS, Hamdan SM, Richardson CC, Kay BK.

Biochim Biophys Acta. 2008 Nov;1784(11):1735-41. doi: 10.1016/j.bbapap.2008.06.022. Epub 2008 Jul 11.


Whole-genome detection of conditionally essential and dispensable genes in Escherichia coli via genetic footprinting.

Scholle MD, Gerdes SY.

Methods Mol Biol. 2008;416:83-102. doi: 10.1007/978-1-59745-321-9_6.

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