Send to

Choose Destination
Am J Respir Crit Care Med. 2018 Apr 15;197(8):991-993. doi: 10.1164/rccm.201711-2216CP.

Unproven and Expensive before Proven and Cheap: Extracorporeal Membrane Oxygenation versus Prone Position in Acute Respiratory Distress Syndrome.

Li X1,2,3, Scales DC3,4, Kavanagh BP1,3.

Author information

1 Department of Critical Care Medicine and Anesthesia, Hospital for Sick Children, University of Toronto, Toronto, Canada.
2 Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
3 Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada; and.
4 Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Canada.


We identified 810 reports that describe extracorporeal membrane oxygenation (ECMO) in acute respiratory distress syndrome (ARDS), and 61 fulfilled our inclusion criteria. The authors of 26 (43%) reports responded to e-mail requests for confirmation (or clarification). Based on the aggregate (published and e-mailed) information, unambiguous data were available relating to 17 papers. These 17 papers represented 672 patients with ARDS who were cannulated with venovenous ECMO; of these patients, 208 (31%) received a trial of prone positioning before ECMO, and 464 (69%) did not. A key randomized controlled trial was published in 2013 that reported a survival benefit associated with prone positioning (N Engl J Med 2013;368:2159-2168). The proportion of all venovenous ECMO patients in whom prone positioning was used before ECMO was lower in studies published after 2013 (84 of 452 [19%]) than in those published before 2013 (116 of 210 [55%]) (Pā€‰<ā€‰0.05). These data suggest a systematic bias in the reporting of outcomes after ECMO in the literature. The vast majority of reported patients who received ECMO did not first receive therapy that (in contrast to ECMO) is simple, cheap, and of proven benefit; therefore, inferences about the efficacy of ECMO in ARDS are of limited use.


acute respiratory distress syndrome; extracorporeal membrane oxygenation; prone positioning

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center