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Items: 1 to 20 of 405

1.

"The Pharmacogenomics Research Network Translational Pharmacogenetics Program: Outcomes and Metrics of Pharmacogenetic Implementations Across Diverse Healthcare Systems".

Luzum JA, Pakyz RE, Elsey AR, Haidar CE, Peterson JF, Whirl-Carrillo M, Handelman SK, Palmer K, Pulley JM, Beller M, Schildcrout JS, Field JR, Weitzel KW, Cooper-DeHoff RM, Cavallari LH, O'Donnell PH, Altman RB, Pereira N, Ratain MJ, Roden DM, Embi PJ, Sadee W, Klein TE, Johnson JA, Relling MV, Wang L, Weinshilboum RM, Shuldiner AR, Freimuth RR; Pharmacogenomics Research Network Translational Pharmacogenetics Program..

Clin Pharmacol Ther. 2017 Jan 16. doi: 10.1002/cpt.630. [Epub ahead of print]

PMID:
28090649
2.

The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response.

Biernacka JM, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmöller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Baune BT, Kato M, Liu YL, Praphanphoj V, Stingl JC, Tsai SJ, Kubo M, Klein TE, Weinshilboum R.

Transl Psychiatry. 2016 Nov 1;6(11):e937. doi: 10.1038/tp.2016.187. No abstract available.

PMID:
27801898
3.

Imputing gene expression to maximize platform compatibility.

Zhou W, Han L, Altman RB.

Bioinformatics. 2016 Oct 22. pii: btw664. doi: 10.1093/bioinformatics/btw664. [Epub ahead of print]

4.

PharmGKB summary: very important pharmacogene information for MT-RNR1.

Barbarino JM, McGregor TL, Altman RB, Klein TE.

Pharmacogenet Genomics. 2016 Dec;26(12):558-567. No abstract available.

PMID:
27654872
5.

Computing disease incidence, prevalence and comorbidity from electronic medical records.

Bagley SC, Altman RB.

J Biomed Inform. 2016 Oct;63:108-111. doi: 10.1016/j.jbi.2016.08.005.

PMID:
27498067
6.

Estimation of Maximum Recommended Therapeutic Dose Using Predicted Promiscuity and Potency.

Liu T, Oprea T, Ursu O, Hasselgren C, Altman RB.

Clin Transl Sci. 2016 Dec;9(6):311-320. doi: 10.1111/cts.12422.

7.

Predicting inpatient clinical order patterns with probabilistic topic models vs conventional order sets.

Chen JH, Goldstein MK, Asch SM, Mackey L, Altman RB.

J Am Med Inform Assoc. 2016 Sep 20. pii: ocw136. doi: 10.1093/jamia/ocw136. [Epub ahead of print]

8.

Response to Open Peer Commentaries on "Human Germline CRISPR-Cas Modification: Toward a Regulatory Framework".

Evitt NH, Mascharak S, Altman RB.

Am J Bioeth. 2016 Oct;16(10):W1-2. doi: 10.1080/15265161.2016.1214308. No abstract available.

PMID:
27653416
9.

Population-specific single-nucleotide polymorphism confers increased risk of venous thromboembolism in African Americans.

Daneshjou R, Cavallari LH, Weeke PE, Karczewski KJ, Drozda K, Perera MA, Johnson JA, Klein TE, Bustamante CD, Roden DM, Shaffer C, Denny JC, Zehnder JL, Altman RB.

Mol Genet Genomic Med. 2016 Jun 21;4(5):513-20. doi: 10.1002/mgg3.226.

10.

PharmGKB summary: ivacaftor pathway, pharmacokinetics/pharmacodynamics.

Fohner AE, McDonagh EM, Clancy JP, Whirl Carrillo M, Altman RB, Klein TE.

Pharmacogenet Genomics. 2017 Jan;27(1):39-42. No abstract available.

PMID:
27636560
11.

STAMS: STRING-assisted module search for genome wide association studies and application to autism.

Hillenmeyer S, Davis LK, Gamazon ER, Cook EH, Cox NJ, Altman RB.

Bioinformatics. 2016 Dec 15;32(24):3815-3822.

12.

Predicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features.

Yu KH, Zhang C, Berry GJ, Altman RB, Ré C, Rubin DL, Snyder M.

Nat Commun. 2016 Aug 16;7:12474. doi: 10.1038/ncomms12474.

13.

Engineering a Prototypic P-type ATPase Listeria monocytogenes Ca(2+)-ATPase 1 for Single-Molecule FRET Studies.

Dyla M, Andersen JL, Kjaergaard M, Birkedal V, Terry DS, Altman RB, Blanchard SC, Nissen P, Knudsen CR.

Bioconjug Chem. 2016 Sep 21;27(9):2176-87. doi: 10.1021/acs.bioconjchem.6b00387.

PMID:
27501274
14.

Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.

Cocozaki AI, Altman RB, Huang J, Buurman ET, Kazmirski SL, Doig P, Prince DB, Blanchard SC, Cate JH, Ferguson AD.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8188-93. doi: 10.1073/pnas.1605127113.

15.

PharmGKB summary: isoniazid pathway, pharmacokinetics.

Klein DJ, Boukouvala S, McDonagh EM, Shuldiner SR, Laurieri N, Thorn CF, Altman RB, Klein TE.

Pharmacogenet Genomics. 2016 Sep;26(9):436-44. doi: 10.1097/FPC.0000000000000232. No abstract available.

PMID:
27232112
16.

Towards Clinical Bioinformatics: Redux 2015.

Altman RB.

Yearb Med Inform. 2016 May 20;Suppl 1:S6-7. doi: 10.15265/IYS-2016-s007.

PMID:
27199190
17.

Constraints on Biological Mechanism from Disease Comorbidity Using Electronic Medical Records and Database of Genetic Variants.

Bagley SC, Sirota M, Chen R, Butte AJ, Altman RB.

PLoS Comput Biol. 2016 Apr 26;12(4):e1004885. doi: 10.1371/journal.pcbi.1004885.

18.

A research roadmap for next-generation sequencing informatics.

Altman RB, Prabhu S, Sidow A, Zook JM, Goldfeder R, Litwack D, Ashley E, Asimenos G, Bustamante CD, Donigan K, Giacomini KM, Johansen E, Khuri N, Lee E, Liang XS, Salit M, Serang O, Tezak Z, Wall DP, Mansfield E, Kass-Hout T.

Sci Transl Med. 2016 Apr 20;8(335):335ps10. doi: 10.1126/scitranslmed.aaf7314. Review.

PMID:
27099173
19.

Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity.

Burridge PW, Li YF, Matsa E, Wu H, Ong SG, Sharma A, Holmström A, Chang AC, Coronado MJ, Ebert AD, Knowles JW, Telli ML, Witteles RM, Blau HM, Bernstein D, Altman RB, Wu JC.

Nat Med. 2016 May;22(5):547-56. doi: 10.1038/nm.4087.

20.

Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation.

Wasserman MR, Alejo JL, Altman RB, Blanchard SC.

Nat Struct Mol Biol. 2016 Apr;23(4):333-41. doi: 10.1038/nsmb.3177.

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