Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 20 of 481


Three classes of recurrent DNA break clusters in brain progenitors identified by 3D proximity-based break joining assay.

Wei PC, Lee CS, Du Z, Schwer B, Zhang Y, Kao J, Zurita J, Alt FW.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1919-1924. doi: 10.1073/pnas.1719907115. Epub 2018 Feb 5.


DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions.

Panchakshari RA, Zhang X, Kumar V, Du Z, Wei PC, Kao J, Dong J, Alt FW.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):762-767. doi: 10.1073/pnas.1719988115. Epub 2018 Jan 8.


Mechanism of tandem duplication formation in BRCA1-mutant cells.

Willis NA, Frock RL, Menghi F, Duffey EE, Panday A, Camacho V, Hasty EP, Liu ET, Alt FW, Scully R.

Nature. 2017 Nov 30;551(7682):590-595. doi: 10.1038/nature24477. Epub 2017 Nov 22.


Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination.

Nguyen HV, Dong J, Panchakshari RA, Kumar V, Alt FW, Bories JC.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10560-E10567. doi: 10.1073/pnas.1701366114. Epub 2017 Nov 20.


Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70.

Xing M, Bjørås M, Daniel JA, Alt FW, Oksenych V.

DNA Repair (Amst). 2017 Sep;57:133-138. doi: 10.1016/j.dnarep.2017.07.008. Epub 2017 Jul 26.


AID Recognizes Structured DNA for Class Switch Recombination.

Qiao Q, Wang L, Meng FL, Hwang JK, Alt FW, Wu H.

Mol Cell. 2017 Aug 3;67(3):361-373.e4. doi: 10.1016/j.molcel.2017.06.034. Epub 2017 Jul 27.


Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies.

Hwang JK, Wang C, Du Z, Meyers RM, Kepler TB, Neuberg D, Kwong PD, Mascola JR, Joyce MG, Bonsignori M, Haynes BF, Yeap LS, Alt FW.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8614-8619. doi: 10.1073/pnas.1709203114. Epub 2017 Jul 26.


Characterization of physiological defects in adult SIRT6-/- mice.

Peshti V, Obolensky A, Nahum L, Kanfi Y, Rathaus M, Avraham M, Tinman S, Alt FW, Banin E, Cohen HY.

PLoS One. 2017 Apr 27;12(4):e0176371. doi: 10.1371/journal.pone.0176371. eCollection 2017.


Phosphatidylinositol 3-kinase δ blockade increases genomic instability in B cells.

Compagno M, Wang Q, Pighi C, Cheong TC, Meng FL, Poggio T, Yeap LS, Karaca E, Blasco RB, Langellotto F, Ambrogio C, Voena C, Wiestner A, Kasar SN, Brown JR, Sun J, Wu CJ, Gostissa M, Alt FW, Chiarle R.

Nature. 2017 Feb 23;542(7642):489-493. doi: 10.1038/nature21406. Epub 2017 Feb 15.


Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies.

Verkoczy L, Alt FW, Tian M.

Immunol Rev. 2017 Jan;275(1):89-107. doi: 10.1111/imr.12505. Review.


An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments.

Chen L, Zhao L, Alt FW, Krangel MS.

J Immunol. 2016 Oct 15;197(8):3188-3197. Epub 2016 Sep 9.


Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires.

Tian M, Cheng C, Chen X, Duan H, Cheng HL, Dao M, Sheng Z, Kimble M, Wang L, Lin S, Schmidt SD, Du Z, Joyce MG, Chen Y, DeKosky BJ, Chen Y, Normandin E, Cantor E, Chen RE, Doria-Rose NA, Zhang Y, Shi W, Kong WP, Choe M, Henry AR, Laboune F, Georgiev IS, Huang PY, Jain S, McGuire AT, Georgeson E, Menis S, Douek DC, Schief WR, Stamatatos L, Kwong PD, Shapiro L, Haynes BF, Mascola JR, Alt FW.

Cell. 2016 Sep 8;166(6):1471-1484.e18. doi: 10.1016/j.cell.2016.07.029.


PAXX and XLF DNA repair factors are functionally redundant in joining DNA breaks in a G1-arrested progenitor B-cell line.

Kumar V, Alt FW, Frock RL.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):10619-24. doi: 10.1073/pnas.1611882113. Epub 2016 Sep 6.


Orientation-specific RAG activity in chromosomal loop domains contributes to Tcrd V(D)J recombination during T cell development.

Zhao L, Frock RL, Du Z, Hu J, Chen L, Krangel MS, Alt FW.

J Exp Med. 2016 Aug 22;213(9):1921-36. doi: 10.1084/jem.20160670. Epub 2016 Aug 15.


Highly sensitive and unbiased approach for elucidating antibody repertoires.

Lin SG, Ba Z, Du Z, Zhang Y, Hu J, Alt FW.

Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7846-51. doi: 10.1073/pnas.1608649113. Epub 2016 Jun 27.


Pillars Article: A Functional T3 Molecule Associated with a Novel Heterodimer on the Surface of Immature Human Thymocytes. Nature. 1986. 322: 179-181.

Bank I, DePinho RA, Brenner MB, Cassimeris J, Alt FW, Chess L.

J Immunol. 2016 May 1;196(9):3514-6. Epub 2016 Apr 18. No abstract available.


Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing.

Hu J, Meyers RM, Dong J, Panchakshari RA, Alt FW, Frock RL.

Nat Protoc. 2016 May;11(5):853-71. doi: 10.1038/nprot.2016.043. Epub 2016 Mar 31.


Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells.

Schwer B, Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2258-63. doi: 10.1073/pnas.1525564113. Epub 2016 Feb 12.


Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells.

Wei PC, Chang AN, Kao J, Du Z, Meyers RM, Alt FW, Schwer B.

Cell. 2016 Feb 11;164(4):644-55. doi: 10.1016/j.cell.2015.12.039.


Sequential activation and distinct functions for distal and proximal modules within the IgH 3' regulatory region.

Garot A, Marquet M, Saintamand A, Bender S, Le Noir S, Rouaud P, Carrion C, Oruc Z, Bébin AG, Moreau J, Lebrigand K, Denizot Y, Alt FW, Cogné M, Pinaud E.

Proc Natl Acad Sci U S A. 2016 Feb 9;113(6):1618-23. doi: 10.1073/pnas.1514090113. Epub 2016 Feb 1.

Supplemental Content

Support Center