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Items: 1 to 20 of 109

1.

siRNA carrying an (E)-vinylphosphonate moiety at the 5' end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

Elkayam E, Parmar R, Brown CR, Willoughby JL, Theile CS, Manoharan M, Joshua-Tor L.

Nucleic Acids Res. 2016 Nov 29. pii: gkw1171. [Epub ahead of print]

2.

Strategies to Determine Assay Format for the Assessment of Neutralizing Antibody Responses to Biotherapeutics.

Wu B, Chung S, Jiang XR, McNally J, Pedras-Vasconcelos J, Pillutla R, White JT, Xu Y, Gupta S.

AAPS J. 2016 Nov;18(6):1335-1350.

PMID:
27495119
3.

Effect of terminal 3'-hydroxymethyl modification of an RNA primer on nonenzymatic primer extension.

Pal A, Das RS, Zhang W, Lang M, McLaughlin LW, Szostak JW.

Chem Commun (Camb). 2016 Sep 29;52(80):11905-11907.

PMID:
27722518
4.

The RNA-binding protein vigilin regulates VLDL secretion through modulation of Apob mRNA translation.

Mobin MB, Gerstberger S, Teupser D, Campana B, Charisse K, Heim MH, Manoharan M, Tuschl T, Stoffel M.

Nat Commun. 2016 Sep 26;7:12848. doi: 10.1038/ncomms12848.

5.

Evaluation of Therapeutic Oligonucleotides for Familial Amyloid Polyneuropathy in Patient-Derived Hepatocyte-Like Cells.

Niemietz CJ, Sauer V, Stella J, Fleischhauer L, Chandhok G, Guttmann S, Avsar Y, Guo S, Ackermann EJ, Gollob J, Monia BP, Zibert A, Schmidt HH.

PLoS One. 2016 Sep 1;11(9):e0161455. doi: 10.1371/journal.pone.0161455.

6.
7.

Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure.

Sager HB, Hulsmans M, Lavine KJ, Moreira MB, Heidt T, Courties G, Sun Y, Iwamoto Y, Tricot B, Khan OF, Dahlman JE, Borodovsky A, Fitzgerald K, Anderson DG, Weissleder R, Libby P, Swirski FK, Nahrendorf M.

Circ Res. 2016 Sep 16;119(7):853-64. doi: 10.1161/CIRCRESAHA.116.309001.

PMID:
27444755
8.

An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria.

Liebow A, Li X, Racie T, Hettinger J, Bettencourt BR, Najafian N, Haslett P, Fitzgerald K, Holmes RP, Erbe D, Querbes W, Knight J.

J Am Soc Nephrol. 2016 Jul 18. pii: ASN.2016030338. [Epub ahead of print]

PMID:
27432743
9.

Exposure to siRNA-GalNAc Conjugates in Systems of the Standard Test Battery for Genotoxicity.

Janas MM, Jiang Y, Duncan RG, Hayes AN, Liu J, Kasperkovitz PV, Placke ME, Barros SA.

Nucleic Acid Ther. 2016 Dec;26(6):363-371.

PMID:
27387336
10.

Sequence-Defined Oligomers from Hydroxyproline Building Blocks for Parallel Synthesis Applications.

Kanasty RL, Vegas AJ, Ceo LM, Maier M, Charisse K, Nair JK, Langer R, Anderson DG.

Angew Chem Int Ed Engl. 2016 Aug 8;55(33):9529-33. doi: 10.1002/anie.201602748.

PMID:
27365192
11.

Pharmacokinetics of Tacrolimus and Cyclosporine in Liver Transplant Recipients Receiving 3 Direct-Acting Antivirals as Treatment for Hepatitis C Infection.

Badri PS, Parikh A, Coakley EP, Ding B, Awni WM, Dutta S, Menon RM.

Ther Drug Monit. 2016 Oct;38(5):640-5. doi: 10.1097/FTD.0000000000000315.

PMID:
27310199
12.

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction.

Sager HB, Dutta P, Dahlman JE, Hulsmans M, Courties G, Sun Y, Heidt T, Vinegoni C, Borodovsky A, Fitzgerald K, Wojtkiewicz GR, Iwamoto Y, Tricot B, Khan OF, Kauffman KJ, Xing Y, Shaw TE, Libby P, Langer R, Weissleder R, Swirski FK, Anderson DG, Nahrendorf M.

Sci Transl Med. 2016 Jun 8;8(342):342ra80. doi: 10.1126/scitranslmed.aaf1435.

13.

Cutaneous Adverse Events in the Randomized, Double-Blind, Active-Comparator DECIDE Study of Daclizumab High-Yield Process Versus Intramuscular Interferon Beta-1a in Relapsing-Remitting Multiple Sclerosis.

Krueger JG, Kircik L, Hougeir F, Friedman A, You X, Lucas N, Greenberg SJ, Sweetser M, Castro-Borrero W, McCroskery P, Elkins J.

Adv Ther. 2016 Jul;33(7):1231-45. doi: 10.1007/s12325-016-0353-2.

14.

Continuous intranigral infusion is not associated with observable behavioral deficits or marked pathology: a preclinical safety study.

Grondin R, Ai Y, Hardy PA, Butt MT, Nelson BD, Lemmon JD, Bumcrot D, Gash DM, Gerhardt GA, Zhang Z.

J Neurosurg. 2016 May 27:1-10. [Epub ahead of print]

PMID:
27231974
15.

5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.

Parmar R, Willoughby JL, Liu J, Foster DJ, Brigham B, Theile CS, Charisse K, Akinc A, Guidry E, Pei Y, Strapps W, Cancilla M, Stanton MG, Rajeev KG, Sepp-Lorenzino L, Manoharan M, Meyers R, Maier MA, Jadhav V.

Chembiochem. 2016 Jun 2;17(11):985-9. doi: 10.1002/cbic.201600130.

PMID:
27121751
16.

Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis.

Butler JS, Chan A, Costelha S, Fishman S, Willoughby JL, Borland TD, Milstein S, Foster DJ, Gonçalves P, Chen Q, Qin J, Bettencourt BR, Sah DW, Alvarez R, Rajeev KG, Manoharan M, Fitzgerald K, Meyers RE, Nochur SV, Saraiva MJ, Zimmermann TS.

Amyloid. 2016 Jun;23(2):109-18. doi: 10.3109/13506129.2016.1160882.

17.

OSWG Recommendations for Genotoxicity Testing of Novel Oligonucleotide-Based Therapeutics.

Berman CL, Barros SA, Galloway SM, Kasper P, Oleson FB, Priestley CC, Sweder KS, Schlosser MJ, Sobol Z.

Nucleic Acid Ther. 2016 Apr;26(2):73-85. doi: 10.1089/nat.2015.0534.

PMID:
26978711
18.

Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides.

Kel'in AV, Zlatev I, Harp J, Jayaraman M, Bisbe A, O'Shea J, Taneja N, Manoharan RM, Khan S, Charisse K, Maier MA, Egli M, Rajeev KG, Manoharan M.

J Org Chem. 2016 Mar 18;81(6):2261-79. doi: 10.1021/acs.joc.5b02375.

PMID:
26940174
19.

A novel LC-MS/MS assay for heparan sulfate screening in the cerebrospinal fluid of mucopolysaccharidosis IIIA patients.

Naimy H, Powell KD, Moriarity JR, Wu J, McCauley TG, Haslett PA, Barbier AJ, Qiu Y.

Bioanalysis. 2016 Feb;8(4):285-95. doi: 10.4155/bio.15.243.

PMID:
26847798
20.

Dectin-1 Controls TLR9 Trafficking to Phagosomes Containing β-1,3 Glucan.

Khan NS, Kasperkovitz PV, Timmons AK, Mansour MK, Tam JM, Seward MW, Reedy JL, Puranam S, Feliu M, Vyas JM.

J Immunol. 2016 Mar 1;196(5):2249-61. doi: 10.4049/jimmunol.1401545.

PMID:
26829985
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