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Items: 1 to 20 of 49


Design and preclinical characterization of ALXN1210: A novel anti-C5 antibody with extended duration of action.

Sheridan D, Yu ZX, Zhang Y, Patel R, Sun F, Lasaro MA, Bouchard K, Andrien B, Marozsan A, Wang Y, Tamburini P.

PLoS One. 2018 Apr 12;13(4):e0195909. doi: 10.1371/journal.pone.0195909. eCollection 2018.


Specific Inhibition of Complement Activation Significantly Ameliorates Autoimmune Blistering Disease in Mice.

Mihai S, Hirose M, Wang Y, Thurman JM, Holers VM, Morgan BP, Köhl J, Zillikens D, Ludwig RJ, Nimmerjahn F.

Front Immunol. 2018 Mar 16;9:535. doi: 10.3389/fimmu.2018.00535. eCollection 2018.


Patient-derived lymphoblastoid cell lines harboring mitochondrial DNA mutations as tool for small molecule drug discovery.

Chin RM, Panavas T, Brown JM, Johnson KK.

BMC Res Notes. 2018 Mar 27;11(1):205. doi: 10.1186/s13104-018-3297-6.


Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva.

Lees-Shepard JB, Yamamoto M, Biswas AA, Stoessel SJ, Nicholas SE, Cogswell CA, Devarakonda PM, Schneider MJ Jr., Cummins SM, Legendre NP, Yamamoto S, Kaartinen V, Hunter JW, Goldhamer DJ.

Nat Commun. 2018 Feb 2;9(1):471. doi: 10.1038/s41467-018-02872-2.


Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program.

Wang P, Wander CM, Yuan CX, Bereman MS, Cohen TJ.

Nat Commun. 2017 Jul 19;8(1):82. doi: 10.1038/s41467-017-00088-4.


A Bayesian mathematical model of motor and cognitive outcomes in Parkinson's disease.

Hayete B, Wuest D, Laramie J, McDonagh P, Church B, Eberly S, Lang A, Marek K, Runge K, Shoulson I, Singleton A, Tanner C, Khalil I, Verma A, Ravina B.

PLoS One. 2017 Jun 12;12(6):e0178982. doi: 10.1371/journal.pone.0178982. eCollection 2017.


A Systematic Review and Pooled Analysis of Select Safety Parameters Among Normal Healthy Volunteers Taking Placebo in Phase 1 Clinical Trials.

Young TC, Srinivasan S, Vetter ML, Sethuraman V, Bhagwagar Z, Zwirtes R, Narasimhan P, Chuang T, Smyth BJ.

J Clin Pharmacol. 2017 Sep;57(9):1079-1087. doi: 10.1002/jcph.913. Epub 2017 May 16. Review.


Microbial Neuraminidase Induces a Moderate and Transient Myelin Vacuolation Independent of Complement System Activation.

Granados-Durán P, López-Ávalos MD, Cifuentes M, Pérez-Martín M, Fernández-Arjona MD, Hughes TR, Johnson K, Morgan BP, Fernández-Llebrez P, Grondona JM.

Front Neurol. 2017 Mar 7;8:78. doi: 10.3389/fneur.2017.00078. eCollection 2017.


A Dual Pathogenic Mechanism Links Tau Acetylation to Sporadic Tauopathy.

Trzeciakiewicz H, Tseng JH, Wander CM, Madden V, Tripathy A, Yuan CX, Cohen TJ.

Sci Rep. 2017 Mar 13;7:44102. doi: 10.1038/srep44102.


Societal perspective on access to publicly subsidised medicines: A cross sectional survey of 3080 adults in Australia.

Chim L, Salkeld G, Kelly P, Lipworth W, Hughes DA, Stockler MR.

PLoS One. 2017 Mar 1;12(3):e0172971. doi: 10.1371/journal.pone.0172971. eCollection 2017.


Survival in infants treated with sebelipase Alfa for lysosomal acid lipase deficiency: an open-label, multicenter, dose-escalation study.

Jones SA, Rojas-Caro S, Quinn AG, Friedman M, Marulkar S, Ezgu F, Zaki O, Gargus JJ, Hughes J, Plantaz D, Vara R, Eckert S, Arnoux JB, Brassier A, Le Quan Sang KH, Valayannopoulos V.

Orphanet J Rare Dis. 2017 Feb 8;12(1):25. doi: 10.1186/s13023-017-0587-3.


The temporal impact of aging on the burden of herpes zoster.

Varghese L, Standaert B, Olivieri A, Curran D.

BMC Geriatr. 2017 Jan 23;17(1):30. doi: 10.1186/s12877-017-0420-9.


Bayesian Network Inference Modeling Identifies TRIB1 as a Novel Regulator of Cell-Cycle Progression and Survival in Cancer Cells.

Gendelman R, Xing H, Mirzoeva OK, Sarde P, Curtis C, Feiler HS, McDonagh P, Gray JW, Khalil I, Korn WM.

Cancer Res. 2017 Apr 1;77(7):1575-1585. doi: 10.1158/0008-5472.CAN-16-0512. Epub 2017 Jan 13.


Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members.

Hwang AW, Trzeciakiewicz H, Friedmann D, Yuan CX, Marmorstein R, Lee VM, Cohen TJ.

PLoS One. 2016 Dec 21;11(12):e0168913. doi: 10.1371/journal.pone.0168913. eCollection 2016.


Asfotase alfa therapy for children with hypophosphatasia.

Whyte MP, Madson KL, Phillips D, Reeves AL, McAlister WH, Yakimoski A, Mack KE, Hamilton K, Kagan K, Fujita KP, Thompson DD, Moseley S, Odrljin T, Rockman-Greenberg C.

JCI Insight. 2016 Jun 16;1(9):e85971.


Calpain inhibition reduces structural and functional impairment of retinal ganglion cells in experimental optic neuritis.

Smith AW, Rohrer B, Wheless L, Samantaray S, Ray SK, Inoue J, Azuma M, Banik NL.

J Neurochem. 2016 Oct;139(2):270-284. doi: 10.1111/jnc.13770. Epub 2016 Sep 27.


Characterizing absolute lymphocyte count profiles in dimethyl fumarate-treated patients with MS: Patient management considerations.

Fox RJ, Chan A, Gold R, Phillips JT, Selmaj K, Chang I, Novas M, Rana J, Marantz JL.

Neurol Clin Pract. 2016 Jun;6(3):220-229.


Complement system activation contributes to the ependymal damage induced by microbial neuraminidase.

Granados-Durán P, López-Ávalos MD, Hughes TR, Johnson K, Morgan BP, Tamburini PP, Fernández-Llebrez P, Grondona JM.

J Neuroinflammation. 2016 May 21;13(1):115. doi: 10.1186/s12974-016-0576-9.


Complement C5 Inhibition Reduces T Cell-Mediated Allograft Vasculopathy Caused by Both Alloantibody and Ischemia Reperfusion Injury in Humanized Mice.

Qin L, Li G, Kirkiles-Smith N, Clark P, Fang C, Wang Y, Yu ZX, Devore D, Tellides G, Pober JS, Jane-Wit D.

Am J Transplant. 2016 Oct;16(10):2865-2876. doi: 10.1111/ajt.13834. Epub 2016 Jun 14.


Endoplasmic reticulum stress-induced apoptosis accompanies enhanced expression of multiple inositol polyphosphate phosphatase 1 (Minpp1): a possible role for Minpp1 in cellular stress response.

Kilaparty SP, Agarwal R, Singh P, Kannan K, Ali N.

Cell Stress Chaperones. 2016 Jul;21(4):593-608. doi: 10.1007/s12192-016-0684-6. Epub 2016 Apr 2.

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