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Is neoadjuvant chemoradiation with dose-escalation and consolidation chemotherapy sufficient to increase surgery-free and distant metastases-free survival in baseline cT3 rectal cancer?

São Julião GP, Habr-Gama A, Vailati BB, Aguilar PB, Sabbaga J, Araújo SEA, Mattacheo A, Alexandre FA, Fernandez LM, Gomes DB, Gama-Rodrigues J, Perez RO.

Eur J Surg Oncol. 2018 Jan;44(1):93-99. doi: 10.1016/j.ejso.2017.11.010. Epub 2017 Nov 26.


Local Excision and Endoscopic Resections for Early Rectal Cancer.

São Julião GP, Celentano JP, Alexandre FA, Vailati BB.

Clin Colon Rectal Surg. 2017 Nov;30(5):313-323. doi: 10.1055/s-0037-1606108. Epub 2017 Nov 27. Review.


The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-α-chloro-2'-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors.

Alexandre FR, Badaroux E, Bilello JP, Bot S, Bouisset T, Brandt G, Cappelle S, Chapron C, Chaves D, Convard T, Counor C, Da Costa D, Dukhan D, Gay M, Gosselin G, Griffon JF, Gupta K, Hernandez-Santiago B, La Colla M, Lioure MP, Milhau J, Paparin JL, Peyronnet J, Parsy C, Pierra Rouvière C, Rahali H, Rahali R, Salanson A, Seifer M, Serra I, Standring D, Surleraux D, Dousson CB.

Bioorg Med Chem Lett. 2017 Sep 15;27(18):4323-4330. doi: 10.1016/j.bmcl.2017.08.029. Epub 2017 Aug 16.


Zero Calcium Score as a Filter for Further Testing in Patients Admitted to the Coronary Care Unit with Chest Pain.

Correia LCL, Esteves FP, Carvalhal M, Souza TMB, Sá N, Correia VCA, Alexandre FKB, Lopes F, Ferreira F, Noya-Rabelo M.

Arq Bras Cardiol. 2017 Jun 12:0. doi: 10.5935/abc.20170076. [Epub ahead of print] English, Portuguese.


Accuracy of gestalt perception of acute chest pain in predicting coronary artery disease.

das Virgens CM, Lemos L Jr, Noya-Rabelo M, Carvalhal MC, Cerqueira Junior AM, Lopes FO, de Sá NC, Suerdieck JG, de Souza TM, Correia VC, Sodré GS, da Silva AB, Alexandre FK, Ferreira FR, Correia LC.

World J Cardiol. 2017 Mar 26;9(3):241-247. doi: 10.4330/wjc.v9.i3.241.


A cognitive behavioral intervention (HOBSCOTCH) improves quality of life and attention in epilepsy.

Caller TA, Ferguson RJ, Roth RM, Secore KL, Alexandre FP, Zhao W, Tosteson TD, Henegan PL, Birney K, Jobst BC.

Epilepsy Behav. 2016 Apr;57(Pt A):111-7. doi: 10.1016/j.yebeh.2016.01.024. Epub 2016 Mar 2.


Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor.

Dousson C, Alexandre FR, Amador A, Bonaric S, Bot S, Caillet C, Convard T, da Costa D, Lioure MP, Roland A, Rosinovsky E, Maldonado S, Parsy C, Trochet C, Storer R, Stewart A, Wang J, Mayes BA, Musiu C, Poddesu B, Vargiu L, Liuzzi M, Moussa A, Jakubik J, Hubbard L, Seifer M, Standring D.

J Med Chem. 2016 Mar 10;59(5):1891-8. doi: 10.1021/acs.jmedchem.5b01430. Epub 2016 Feb 3.


Prevalence of extended-spectrum beta-lactamase producing Escherichia coli in community-onset urinary tract infections in France in 2013.

Martin D, Fougnot S, Grobost F, Thibaut-Jovelin S, Ballereau F, Gueudet T, de Mouy D, Robert J; ONERBA-ville network.

J Infect. 2016 Feb;72(2):201-6. doi: 10.1016/j.jinf.2015.11.009. Epub 2015 Dec 15.


Brain Damage and Motor Cortex Impairment in Chronic Obstructive Pulmonary Disease: Implication of Nonrapid Eye Movement Sleep Desaturation.

Alexandre F, Heraud N, Sanchez AM, Tremey E, Oliver N, Guerin P, Varray A.

Sleep. 2016 Feb 1;39(2):327-35. doi: 10.5665/sleep.5438.


Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320.

Parsy CC, Alexandre FR, Bidau V, Bonnaterre F, Brandt G, Caillet C, Cappelle S, Chaves D, Convard T, Derock M, Gloux D, Griffon Y, Lallos LB, Leroy F, Liuzzi M, Loi AG, Moulat L, Chiara M, Rahali H, Roques V, Rosinovsky E, Savin S, Seifer M, Standring D, Surleraux D.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5427-36. doi: 10.1016/j.bmcl.2015.09.009. Epub 2015 Sep 5.


A parsimonious computational model of visual target position encoding in the superior colliculus.

Taouali W, Goffart L, Alexandre F, Rougier NP.

Biol Cybern. 2015 Oct;109(4-5):549-59. doi: 10.1007/s00422-015-0660-8. Epub 2015 Sep 5.


Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease.

Alexandre FR, Brandt G, Caillet C, Chaves D, Convard T, Derock M, Gloux D, Griffon Y, Lallos L, Leroy F, Liuzzi M, Loi AG, Moulat L, Musiu C, Parsy C, Rahali H, Roques V, Seifer M, Standring D, Surleraux D.

Bioorg Med Chem Lett. 2015 Sep 15;25(18):3984-91. doi: 10.1016/j.bmcl.2015.07.020. Epub 2015 Jul 14.


Integration of exteroceptive and interoceptive information within the hippocampus: a computational study.

Kassab R, Alexandre F.

Front Syst Neurosci. 2015 Jun 5;9:87. doi: 10.3389/fnsys.2015.00087. eCollection 2015.


Asymptomatic individuals with high HDL-C levels overexpress ABCA1 and ABCG1 and present miR-33a dysregulation in peripheral blood mononuclear cells.

Scherrer DZ, Zago VH, Parra ES, Avansini S, Panzoldo NB, Alexandre F, Baracat J, Nakandakare ER, Quintão EC, de Faria EC.

Gene. 2015 Oct 1;570(1):50-6. doi: 10.1016/j.gene.2015.05.074. Epub 2015 Jun 4.


p.Q192R SNP of PON1 seems not to be Associated with Carotid Atherosclerosis Risk Factors in an Asymptomatic and Normolipidemic Brazilian Population Sample.

Scherrer DZ, Zago VH, Vieira IC, Parra ES, Panzoldo NB, Alexandre F, Secolin R, Baracat J, Quintão EC, Faria EC.

Arq Bras Cardiol. 2015 Jul;105(1):45-52. doi: 10.5935/abc.20150053. Epub 2015 May 29. English, Portuguese.


A pavlovian model of the amygdala and its influence within the medial temporal lobe.

Carrere M, Alexandre F.

Front Syst Neurosci. 2015 Mar 18;9:41. doi: 10.3389/fnsys.2015.00041. eCollection 2015.


Cortical motor output decreases after neuromuscular fatigue induced by electrical stimulation of the plantar flexor muscles.

Alexandre F, Derosiere G, Papaiordanidou M, Billot M, Varray A.

Acta Physiol (Oxf). 2015 May;214(1):124-34. doi: 10.1111/apha.12478. Epub 2015 Mar 18.


Design and feasibility of a memory intervention with focus on self-management for cognitive impairment in epilepsy.

Caller TA, Secore KL, Ferguson RJ, Roth RM, Alexandre FP, Henegan PL, Harrington JJ, Jobst BC.

Epilepsy Behav. 2015 Mar;44:192-4. doi: 10.1016/j.yebeh.2014.12.036. Epub 2015 Feb 27.


Reference values for high-density lipoprotein particle size and volume by dynamic light scattering in a Brazilian population sample and their relationships with metabolic parameters.

Alexandre F, Zago VH, Panzoldo NB, Parra ES, Scherrer DZ, Vendrame F, Nunes VS, Gomes EI, Marcato PD, Nakandakare ER, Quintão EC, de Faria EC.

Clin Chim Acta. 2015 Mar 10;442:63-72. doi: 10.1016/j.cca.2015.01.006. Epub 2015 Jan 14.


HDL size is more accurate than HDL cholesterol to predict carotid subclinical atherosclerosis in individuals classified as low cardiovascular risk.

Parra ES, Panzoldo NB, Zago VH, Scherrer DZ, Alexandre F, Bakkarat J, Nunes VS, Nakandakare ER, Quintão EC, Nadruz-Jr W, de Faria EC, Sposito AC.

PLoS One. 2014 Dec 3;9(12):e114212. doi: 10.1371/journal.pone.0114212. eCollection 2014.

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