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Items: 1 to 20 of 38


Identification and structural characterization of LytU, a unique peptidoglycan endopeptidase from the lysostaphin family.

Raulinaitis V, Tossavainen H, Aitio O, Juuti JT, Hiramatsu K, Kontinen V, Permi P.

Sci Rep. 2017 Jul 20;7(1):6020. doi: 10.1038/s41598-017-06135-w.


1H, 13C and 15N resonance assignments of the new lysostaphin family endopeptidase catalytic domain from Staphylococcus aureus.

Raulinaitis V, Tossavainen H, Aitio O, Seppala R, Permi P.

Biomol NMR Assign. 2017 Apr;11(1):69-73. doi: 10.1007/s12104-016-9722-7. Epub 2016 Dec 9.


Structural Basis of the High Affinity Interaction between the Alphavirus Nonstructural Protein-3 (nsP3) and the SH3 Domain of Amphiphysin-2.

Tossavainen H, Aitio O, Hellman M, Saksela K, Permi P.

J Biol Chem. 2016 Jul 29;291(31):16307-17. doi: 10.1074/jbc.M116.732412. Epub 2016 Jun 6.


Hassallidins, antifungal glycolipopeptides, are widespread among cyanobacteria and are the end-product of a nonribosomal pathway.

Vestola J, Shishido TK, Jokela J, Fewer DP, Aitio O, Permi P, Wahlsten M, Wang H, Rouhiainen L, Sivonen K.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1909-17. doi: 10.1073/pnas.1320913111. Epub 2014 Apr 17.


New structural variants of aeruginosin produced by the toxic bloom forming cyanobacterium Nodularia spumigena.

Fewer DP, Jokela J, Paukku E, Österholm J, Wahlsten M, Permi P, Aitio O, Rouhiainen L, Gomez-Saez GV, Sivonen K.

PLoS One. 2013 Sep 6;8(9):e73618. doi: 10.1371/journal.pone.0073618. eCollection 2013.


Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly.

Aitio O, Hellman M, Skehan B, Kesti T, Leong JM, Saksela K, Permi P.

Structure. 2012 Oct 10;20(10):1692-703. doi: 10.1016/j.str.2012.07.015. Epub 2012 Aug 23.


Diversity in prokaryotic glycosylation: an archaeal-derived N-linked glycan contains legionaminic acid.

Kandiba L, Aitio O, Helin J, Guan Z, Permi P, Bamford DH, Eichler J, Roine E.

Mol Microbiol. 2012 May;84(3):578-93. doi: 10.1111/j.1365-2958.2012.08045.x. Epub 2012 Apr 11.


Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly.

Aitio O, Hellman M, Kazlauskas A, Vingadassalom DF, Leong JM, Saksela K, Permi P.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21743-8. doi: 10.1073/pnas.1010243107. Epub 2010 Nov 22.


Glucuronidation of racemic O-desmethyltramadol, the active metabolite of tramadol.

Lehtonen P, Sten T, Aitio O, Kurkela M, Vuorensola K, Finel M, Kostiainen R.

Eur J Pharm Sci. 2010 Nov 20;41(3-4):523-30. doi: 10.1016/j.ejps.2010.08.005. Epub 2010 Aug 24.


HA-detected experiments for the backbone assignment of intrinsically disordered proteins.

Mäntylahti S, Aitio O, Hellman M, Permi P.

J Biomol NMR. 2010 Jul;47(3):171-81. doi: 10.1007/s10858-010-9421-0. Epub 2010 May 1.


HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition.

Ekokoski E, Aitio O, Törnquist K, Yli-Kauhaluoma J, Tuominen RK.

Eur J Pharm Sci. 2010 Aug 11;40(5):404-11. doi: 10.1016/j.ejps.2010.04.013. Epub 2010 Apr 28.


The N-glycome of human embryonic stem cells.

Satomaa T, Heiskanen A, Mikkola M, Olsson C, Blomqvist M, Tiittanen M, Jaatinen T, Aitio O, Olonen A, Helin J, Hiltunen J, Natunen J, Tuuri T, Otonkoski T, Saarinen J, Laine J.

BMC Cell Biol. 2009 Jun 2;10:42. doi: 10.1186/1471-2121-10-42.


Synthesis, structure characterization, and enzyme screening of clenbuterol glucuronides.

Alonen A, Gartman M, Aitio O, Finel M, Yli-Kauhaluoma J, Kostiainen R.

Eur J Pharm Sci. 2009 Jul 12;37(5):581-7. doi: 10.1016/j.ejps.2009.05.003. Epub 2009 May 15.


Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C.

Boije af Gennäs G, Talman V, Aitio O, Ekokoski E, Finel M, Tuominen RK, Yli-Kauhaluoma J.

J Med Chem. 2009 Jul 9;52(13):3969-81. doi: 10.1021/jm900229p.


Glycomics of bone marrow-derived mesenchymal stem cells can be used to evaluate their cellular differentiation stage.

Heiskanen A, Hirvonen T, Salo H, Impola U, Olonen A, Laitinen A, Tiitinen S, Natunen S, Aitio O, Miller-Podraza H, Wuhrer M, Deelder AM, Natunen J, Laine J, Lehenkari P, Saarinen J, Satomaa T, Valmu L.

Glycoconj J. 2009 Apr;26(3):367-84. doi: 10.1007/s10719-008-9217-6. Epub 2008 Nov 27.


Structural basis of PxxDY motif recognition in SH3 binding.

Aitio O, Hellman M, Kesti T, Kleino I, Samuilova O, Pääkkönen K, Tossavainen H, Saksela K, Permi P.

J Mol Biol. 2008 Sep 26;382(1):167-78. doi: 10.1016/j.jmb.2008.07.008. Epub 2008 Jul 11.


Acyl group migration and cleavage in selectively protected beta-d-galactopyranosides as studied by NMR spectroscopy and kinetic calculations.

Roslund MU, Aitio O, Wärnå J, Maaheimo H, Murzin DY, Leino R.

J Am Chem Soc. 2008 Jul 9;130(27):8769-72. doi: 10.1021/ja801177s. Epub 2008 Jun 11.


Regio- and stereospecific N-glucuronidation of medetomidine: the differences between UDP glucuronosyltransferase (UGT) 1A4 and UGT2B10 account for the complex kinetics of human liver microsomes.

Kaivosaari S, Toivonen P, Aitio O, Sipilä J, Koskinen M, Salonen JS, Finel M.

Drug Metab Dispos. 2008 Aug;36(8):1529-37. doi: 10.1124/dmd.108.021709. Epub 2008 May 12.


Enzyme-assisted synthesis and structure characterization of glucuronic acid conjugates of losartan, candesartan, and zolarsartan.

Alonen A, Jansson J, Kallonen S, Kiriazis A, Aitio O, Finel M, Kostiainen R.

Bioorg Chem. 2008 Jun;36(3):148-55. doi: 10.1016/j.bioorg.2008.02.004. Epub 2008 Apr 1.


Enzyme-assisted synthesis and structure characterization of glucuronide conjugates of eleven anabolic steroid metabolites.

Hintikka L, Kuuranne T, Aitio O, Thevis M, Schänzer W, Kostiainen R.

Steroids. 2008 Mar;73(3):257-65. Epub 2007 Oct 26.


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