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Items: 1 to 20 of 31


Structural basis of mitochondrial receptor binding and constriction by DRP1.

Kalia R, Wang RY, Yusuf A, Thomas PV, Agard DA, Shaw JM, Frost A.

Nature. 2018 Jun;558(7710):401-405. doi: 10.1038/s41586-018-0211-2. Epub 2018 Jun 13.


Vms1p is a release factor for the ribosome-associated quality control complex.

Zurita Rendón O, Fredrickson EK, Howard CJ, Van Vranken J, Fogarty S, Tolley ND, Kalia R, Osuna BA, Shen PS, Hill CP, Frost A, Rutter J.

Nat Commun. 2018 Jun 6;9(1):2197. doi: 10.1038/s41467-018-04564-3.


The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins.

Shurtleff MJ, Itzhak DN, Hussmann JA, Schirle Oakdale NT, Costa EA, Jonikas M, Weibezahn J, Popova KD, Jan CH, Sinitcyn P, Vembar SS, Hernandez H, Cox J, Burlingame AL, Brodsky J, Frost A, Borner GH, Weissman JS.

Elife. 2018 May 29;7. pii: e37018. doi: 10.7554/eLife.37018.


Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.

Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P.

Science. 2018 Mar 30;359(6383). pii: eaaq0939. doi: 10.1126/science.aaq0939.


Structural inhibition of dynamin-mediated membrane fission by endophilin.

Hohendahl A, Talledge N, Galli V, Shen PS, Humbert F, De Camilli P, Frost A, Roux A.

Elife. 2017 Sep 21;6. pii: e26856. doi: 10.7554/eLife.26856.


CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides.

Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS.

Science. 2017 Jul 28;357(6349):414-417. doi: 10.1126/science.aam7787.


In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing.

Osuna BA, Howard CJ, Kc S, Frost A, Weinberg DE.

Elife. 2017 Jul 18;6. pii: e27949. doi: 10.7554/eLife.27949.


LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells.

Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A.

Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2166-E2175. doi: 10.1073/pnas.1613916114. Epub 2017 Feb 27.


Cell biology: Double agents for mitochondrial division.

McBride HM, Frost A.

Nature. 2016 Dec 1;540(7631):43-44. doi: 10.1038/nature20482. Epub 2016 Nov 23. No abstract available.


Membrane fission by dynamin: what we know and what we need to know.

Antonny B, Burd C, De Camilli P, Chen E, Daumke O, Faelber K, Ford M, Frolov VA, Frost A, Hinshaw JE, Kirchhausen T, Kozlov MM, Lenz M, Low HH, McMahon H, Merrifield C, Pollard TD, Robinson PJ, Roux A, Schmid S.

EMBO J. 2016 Nov 2;35(21):2270-2284. Epub 2016 Sep 26. Review.


A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP.

Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ.

EMBO J. 2016 Nov 2;35(21):2332-2349. Epub 2016 Sep 21.


Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex.

Heider MR, Gu M, Duffy CM, Mirza AM, Marcotte LL, Walls AC, Farrall N, Hakhverdyan Z, Field MC, Rout MP, Frost A, Munson M.

Nat Struct Mol Biol. 2016 Jan;23(1):59-66. doi: 10.1038/nsmb.3146. Epub 2015 Dec 14.


Structure and membrane remodeling activity of ESCRT-III helical polymers.

McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost A.

Science. 2015 Dec 18;350(6267):1548-51. doi: 10.1126/science.aad8305. Epub 2015 Dec 3.


Suppression and reversal of motion perception around the time of the saccade.

Frost A, Niemeier M.

Front Syst Neurosci. 2015 Oct 31;9:143. doi: 10.3389/fnsys.2015.00143. eCollection 2015.


Structural and functional studies of membrane remodeling machines.

Kalia R, Talledge N, Frost A.

Methods Cell Biol. 2015;128:165-200. doi: 10.1016/bs.mcb.2015.02.007. Epub 2015 Apr 8.


Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains.

Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A.

Science. 2015 Jan 2;347(6217):75-8. doi: 10.1126/science.1259724.


Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission.

Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):E1342-51. doi: 10.1073/pnas.1300855110. Epub 2013 Mar 25.


A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress.

Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS.

Cell. 2012 Nov 21;151(5):1042-54. doi: 10.1016/j.cell.2012.10.044.


Aging and the discrimination of 3-D shape from motion and binocular disparity.

Norman JF, Holmin JS, Beers AM, Cheeseman JR, Ronning C, Stethen AG, Frost AL.

Atten Percept Psychophys. 2012 Oct;74(7):1512-21.


Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions.

Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman JS.

Cell. 2012 Jun 8;149(6):1339-52. doi: 10.1016/j.cell.2012.04.028.

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