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Items: 1 to 20 of 33


2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain.

Jeon AB, Ackart DF, Li W, Jackson M, Melander RJ, Melander C, Abramovitch RB, Chicco AJ, Basaraba RJ, Obregón-Henao A.

Sci Rep. 2019 Feb 6;9(1):1513. doi: 10.1038/s41598-018-38064-7.


Mycobacterium tuberculosis Reporter Strains as Tools for Drug Discovery and Development.

Abramovitch RB.

IUBMB Life. 2018 Sep;70(9):818-825. doi: 10.1002/iub.1862. Epub 2018 Apr 29. Review.


HC2091 Kills Mycobacterium tuberculosis by Targeting the MmpL3 Mycolic Acid Transporter.

Zheng H, Williams JT, Coulson GB, Haiderer ER, Abramovitch RB.

Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e02459-17. doi: 10.1128/AAC.02459-17. Print 2018 Jul.


Genetic and metabolic regulation of Mycobacterium tuberculosis acid growth arrest.

Baker JJ, Abramovitch RB.

Sci Rep. 2018 Mar 8;8(1):4168. doi: 10.1038/s41598-018-22343-4.


WhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop in Mycobacterium marinum.

Bosserman RE, Nguyen TT, Sanchez KG, Chirakos AE, Ferrell MJ, Thompson CR, Champion MM, Abramovitch RB, Champion PA.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10772-E10781. doi: 10.1073/pnas.1710167114. Epub 2017 Nov 27.


Targeting Mycobacterium tuberculosis Sensitivity to Thiol Stress at Acidic pH Kills the Bacterium and Potentiates Antibiotics.

Coulson GB, Johnson BK, Zheng H, Colvin CJ, Fillinger RJ, Haiderer ER, Hammer ND, Abramovitch RB.

Cell Chem Biol. 2017 Aug 17;24(8):993-1004.e4. doi: 10.1016/j.chembiol.2017.06.018. Epub 2017 Aug 3.


2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability.

Jeon AB, Obregón-Henao A, Ackart DF, Podell BK, Belardinelli JM, Jackson M, Nguyen TV, Blackledge MS, Melander RJ, Melander C, Johnson BK, Abramovitch RB, Basaraba RJ.

PLoS One. 2017 Jul 27;12(7):e0180925. doi: 10.1371/journal.pone.0180925. eCollection 2017.


A bioluminescent Pseudomonas aeruginosa wound model reveals increased mortality of type 1 diabetic mice to biofilm infection.

Agostinho Hunt AM, Gibson JA, Larrivee CL, O'Reilly S, Navitskaya S, Needle DB, Abramovitch RB, Busik JV, Waters CM.

J Wound Care. 2017 Jul 1;26(Sup7):S24-S33. doi: 10.12968/jowc.2017.26.Sup7.S24.


Small Molecules That Sabotage Bacterial Virulence.

Johnson BK, Abramovitch RB.

Trends Pharmacol Sci. 2017 Apr;38(4):339-362. doi: 10.1016/ Epub 2017 Feb 14. Review.


Inhibitors of Mycobacterium tuberculosis DosRST signaling and persistence.

Zheng H, Colvin CJ, Johnson BK, Kirchhoff PD, Wilson M, Jorgensen-Muga K, Larsen SD, Abramovitch RB.

Nat Chem Biol. 2017 Feb;13(2):218-225. doi: 10.1038/nchembio.2259. Epub 2016 Dec 19.


A Nonsense Mutation in Mycobacterium marinum That Is Suppressible by a Novel Mechanism.

Williams EA, Mba Medie F, Bosserman RE, Johnson BK, Reyna C, Ferrell MJ, Champion MM, Abramovitch RB, Champion PA.

Infect Immun. 2017 Jan 26;85(2). pii: e00653-16. doi: 10.1128/IAI.00653-16. Print 2017 Feb.


Polysorbates prevent biofilm formation and pathogenesis of Escherichia coli O104:H4.

Sloup RE, Cieza RJ, Needle DB, Abramovitch RB, Torres AG, Waters CM.

Biofouling. 2016 Oct;32(9):1131-1140.


Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo.

Liu Y, Tan S, Huang L, Abramovitch RB, Rohde KH, Zimmerman MD, Chen C, Dartois V, VanderVen BC, Russell DG.

J Exp Med. 2016 May 2;213(5):809-25. doi: 10.1084/jem.20151248. Epub 2016 Apr 25.


SPARTA: Simple Program for Automated reference-based bacterial RNA-seq Transcriptome Analysis.

Johnson BK, Scholz MB, Teal TK, Abramovitch RB.

BMC Bioinformatics. 2016 Feb 4;17:66. doi: 10.1186/s12859-016-0923-y.


The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits the Mycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence.

Johnson BK, Colvin CJ, Needle DB, Mba Medie F, Champion PA, Abramovitch RB.

Antimicrob Agents Chemother. 2015 Aug;59(8):4436-45. doi: 10.1128/AAC.00719-15. Epub 2015 May 18.


Macrophage infection models for Mycobacterium tuberculosis.

Johnson BK, Abramovitch RB.

Methods Mol Biol. 2015;1285:329-41. doi: 10.1007/978-1-4939-2450-9_20.


Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment.

VanderVen BC, Fahey RJ, Lee W, Liu Y, Abramovitch RB, Memmott C, Crowe AM, Eltis LD, Perola E, Deininger DD, Wang T, Locher CP, Russell DG.

PLoS Pathog. 2015 Feb 12;11(2):e1004679. doi: 10.1371/journal.ppat.1004679. eCollection 2015 Feb.


Slow growth of Mycobacterium tuberculosis at acidic pH is regulated by phoPR and host-associated carbon sources.

Baker JJ, Johnson BK, Abramovitch RB.

Mol Microbiol. 2014 Oct;94(1):56-69. doi: 10.1111/mmi.12688. Epub 2014 Jul 13.


Mycobacterium tuberculosis responds to chloride and pH as synergistic cues to the immune status of its host cell.

Tan S, Sukumar N, Abramovitch RB, Parish T, Russell DG.

PLoS Pathog. 2013;9(4):e1003282. doi: 10.1371/journal.ppat.1003282. Epub 2013 Apr 4.


aprABC: a Mycobacterium tuberculosis complex-specific locus that modulates pH-driven adaptation to the macrophage phagosome.

Abramovitch RB, Rohde KH, Hsu FF, Russell DG.

Mol Microbiol. 2011 May;80(3):678-94. doi: 10.1111/j.1365-2958.2011.07601.x. Epub 2011 Mar 14.

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