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Dis Markers. 2009;27(6):269-78. doi: 10.3233/DMA-2009-0672.

Clinical implications of adiponectin and inflammatory biomarkers in type 2 diabetes mellitus.

Author information

1
Department of Biochemistry, National Research Center, Dokki, Giza, Egypt. menha_m_swellam@hotmail.com

Abstract

OBJECTIVES:

To study the interrelationships of adiponectin, C-reactive protein (CRP) and fibrinogen with each other in T2DM patients with (T2DM-C) and without complications (T2DM-NC) among healthy individuals.

DESIGN AND METHODS:

The study comprised of 120 T2DM-C, 59 T2DM-NC patients and 40 healthy volunteers. Biochemical markers were determined in the serum.

RESULTS:

Positivity rates of CRP and fibrinogen were significantly increased in T2DM-C as compared to T2DM-NC or controls, whereas adiponectin showed highest level in healthy individuals. Inflammatory biomarkers were inversely correlated with adiponectin (P< 0.01). Lipid profiles, kidney functions and BMI, showed positive significant correlation with CRP and fibrinogen but negative correlation with adiponectin. For better detection of T2DM, the combined sensitivity (98.9%) and specificity (92.5%) of fibrinogen and adiponectin was higher than the combined sensitivity and specificity of fibrinogen and CRP or adiponectin and CRP or than that of the biomarkers alone.

CONCLUSION:

Elevated levels of CRP and fibrinogen and reduced level of adiponectin can be used for early diagnosis of T2DM and can predict diabetic complications.

PMID:
20075509
PMCID:
PMC3834670
DOI:
10.3233/DMA-2009-0672
[Indexed for MEDLINE]
Free PMC Article

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