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J Allergy Clin Immunol. 1999 Feb;103(2 Pt 2):S354-5.

Methodological issues in the study of rare exposures and rare outcomes in perinatal epidemiology.

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Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520-8034, USA.


Epidemiologic study of rare exposures and rare outcomes is complicated. For perinatal epidemiology, a prospective cohort study design is preferred for reproductive outcomes with incidences of at least 5%. Case-control studies are generally used to investigate rare outcomes with incidences from 5 per 1000 to less than 1 per 1000. However, obtaining data on large numbers of rare cases can be difficult. The use of nested case-control designs or nested prospective studies may be particularly useful in perinatal epidemiology.

[Indexed for MEDLINE]

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