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Ann N Y Acad Sci. 1998 Nov 30;855:205-7.

Visualizing odor detection in olfactory cilia by calcium imaging.

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1
Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA. tlein001@umaryland.edu

Abstract

To visualize odor detection in individual cilia of olfactory sensory neurons we have developed a new approach by using high-resolution calcium imaging techniques. Laser scanning confocal microscopy revealed, for the first time, that odor stimuli induce transient Ca2+ elevations in single olfactory cilia. Pharmacological analysis indicates that these Ca2+ signals depend entirely on Ca2+ entry through activated cyclic nucleotide-gated (CNG) channels. This novel approach enables us to monitor the initial steps leading to olfactory perception in a spatially and temporally resolved manner.

PMID:
9929606
[Indexed for MEDLINE]
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